| 词条 | Ann Kiessling |
| 释义 |
|name = Ann Kiessling |image = Ann-Kiessling.jpg |image_size = 180px |caption = Ann A. Kiessling, Ph.D |birth_date = {{birth date and age|1942|03|29}} |birth_name = Ann Anderson |birth_place = Baker City, Oregon, United States |death_date = |death_place = |other_names = |known_for = Discovery of reverse transcriptase activity in normal human cells, founder of the Special Program of Assisted Reproduction, Director of the Bedford Stem Cell Research Foundation |occupation = Stem cell researcher |nationality = American}} Ann A. Kiessling is an American reproductive biologist and one of the leaders in human parthenogenic stem cell research at The Bedford Research Foundation. She was an Associate Professor in teaching hospitals of Harvard Medical School (Brigham and Women's Hospital, Faulkner Hospital, New England Deaconess, Beth Israel Deaconess Medical Center) from 1985 until 2012. BackgroundKiessling was born in Baker City, Oregon, United States, as Ann Anderson. Her father, Col. William Charles Anderson, was a decorated squadron commander in the US Air Force during World War II. She graduated from Klamath Falls High School in 1960 and attended University of Virginia where she received the first of her two bachelor's degrees in Nursing. In 1966 she received her second bachelor's degree in Chemistry from Central Washington University where she also received her master's degree in Organic Chemistry in 1967. In 1971 she earned her Ph.D from Oregon State University in Biochemistry and Biophysics. She did postdoctoral research at Fred Hutchinson Cancer Research Center, Memorial Sloan-Kettering Cancer Center, and University of California, San Diego. Kiessling is mother of three daughters and a son. CareerKiessling is noted for her discovery of reverse transcriptase activity in normal human cells (Kiessling & Goulian).[1] This report pioneered the importance of naturally occurring retrovirus sequences in human genes, now thought to be important to the genetic plasticity involved in human evolution and biology. Prior to this discovery, it had been assumed that reverse transcriptase was an enzyme found only in retroviruses(such as HIV). To understand the normal biologic role of reverse transcriptase, Kiessling began to study eggs and early cleaving embryos.[2][3] Her dual interests in virology and reproductive biology led to research in semen transmission of Human Immunodeficiency Virus (HIV), and the creation of the first laboratory for Human In Vitro Fertilization (IVF) in Oregon in the early 1980s. Harvard Medical School recruited Kiessling in 1985, where she conducted research until 2011.[4][5] Kiessling currently conducts research at the Bedford Stem Cell Research Foundation.[6] The need to conduct biomedical research in areas not funded by the federal government led to the incorporation of the Bedford Stem Cell Research Foundation.[7] The Foundation's controversial Special Program of Assisted Reproduction (SPAR) has helped more than 170 couples affected by HIV disease have healthy babies.[8][9] Because of this success, more than 75 fertility centers throughout the country have implemented the SPAR program, allowing couples to seek care close to home.[10] The techniques developed for the Special Program of Assisted Reproduction have been extended to other diseases of the male genitourinary tract, such as prostatitis and bladder infections. Expertise in human egg biology led Kiessling to develop the country's first human egg donor program for stem cell research in 2000. It remains a research focus today.[11] Among the publications by Kiessling is the first comprehensive look at the influence of accurate science terminology on laws titled, "What is an Embryo," published by the Connecticut Law Review [12] along with rejoinders by Harold Shapiro, Prof John A. Robertson, Prof. Lars Noah, and Father Kevin P. Quinn. The law review addresses the controversy of all of the entities that are currently called embryos with regards to embryonic stem cell research legislation around the world.[13] In 2003, Kiessling wrote Human Embryonic Stem Cells: An Introduction to the Science and Therapeutic Potential, the first textbook on the controversial topic.[14] Kiessling is a member of the California (California Constitution Article XXXV) and Connecticut Stem Cell Research Advisory Boards,[15] and a member of the Embryonic Stem Cell Research Oversight Committees (ESCROS) for Harvard University,[16] Joslin Diabetes Center and Children's Hospital.[17] Kiessling has been cited in articles in The Boston Globe, The Wall Street Journal, Los Angeles Times, The New York Times, and NPR among others. Awards
PublicationsKiessling has published more than 100 scientific papers and given more than 60 lectures to audiences around the world. Selected publications are listed below:
MediaBoston Globe1. ^{{cite journal |vauthors=Kiessling AA, Goulian M |title=Detection of reverse transcriptase activity in human cells |journal=Cancer Research |volume=39 |issue=6 Pt 1 |pages=2062–9 |date=June 1979 |pmid=87260 |url=http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=87260}} 2. ^{{cite journal |vauthors=O'Keefe SJ, Wolfes H, Kiessling AA, Cooper GM |title=Microinjection of antisense c-mos oligonucleotides prevents meiosis II in the maturing mouse egg |journal=Proceedings of the National Academy of Sciences of the United States of America |volume=86 |issue=18 |pages=7038–42 |date=September 1989 |pmid=2476810 |pmc=297988 |doi=10.1073/pnas.86.18.7038}} 3. ^{{cite journal |author=Kiessling AA |title=What is an embryo? |journal=Connecticut Law Review |volume=36 |issue=4 |pages=1051–92 |year=2004 |pmid=15868674}} 4. ^1 {{cite web|title= Jacob Heskel Gabbay Award in Biotechnology and Medicine - Past Winners |url=http://www.rose.brandeis.edu/Center/gabbay_past.html |publisher=Brandeis University |accessdate=23 March 2014}} 5. ^{{cite web|title= Dr. Ann Kiessling Devotes Full Time to Bedford Stem Cell Research Foundation |url=http://www.bedfordresearch.org/article/27110 |publisher= Bedford Stem Cell Research Foundation |accessdate=23 March 2014}} 6. ^{{cite web |url=http://www.bedfordresearch.org/aboutus/aboutus.php?item=about_director |title=About the director |publisher=Bedford Stem Cell Research Foundation |accessdate=8 November 2012}} 7. ^{{cite web| url=http://www.bedfordresearch.org/aboutus/aboutus.php?item=about_director|title=Bedford Stem Cell Research Foundation – Official Website|accessdate=2007-04-13| archiveurl= https://web.archive.org/web/20070407203014/http://www.bedfordresearch.org/aboutus/aboutus.php?item=about_director| archivedate= 7 April 2007 | deadurl= no}} 8. ^{{cite web|title=Pregnancies & Births |work=SPAR - Special Program of Assisted Reproduction |url=http://sementesting.org/index.php/hiv-semen/semen-hiv.html |publisher=Bedford Research Clinical Laboratory |accessdate=8 November 2012}} 9. ^{{cite web|url=http://americanradioworks.publicradio.org/features/fertility_race/part5/|title=Part Five: The Fertility Race - HIV And Fertility By Stephen Smith – American Public Radio Works|accessdate=2007-04-13}} 10. ^{{cite web|title=Pregnancies & Births |work=Collaborating fertility centers |url=http://sementesting.org/index.php/semen-test-hiv/sperm-washing-hiv-center.html |publisher=Bedford Research Clinical Laboratory |accessdate=8 November 2012}} 11. ^{{cite web |url=http://www.bedfordresearch.org/stemcell/stemcell.php?item=stemcell_eggdonor |title=Egg Donor Program History & Overview |publisher=Bedford Stem Cell Research Foundation |accessdate=8 November 2012}} 12. ^{{Cite journal|title=What is an embryo? |url=http://connecticutlawreview.org/archive/vol36/summer/Kiessling.pdf |journal=Connecticut Law Review |date=2004-01-01 |issn=0010-6151 |pmid=15868674 |pages=1051–1092 |volume=36 |issue=4 |first=Ann A. |last=Kiessling |deadurl=yes |archiveurl=https://web.archive.org/web/20060709041838/http://connecticutlawreview.org/archive/vol36/summer/Kiessling.pdf |archivedate=July 9, 2006 }} 13. ^{{cite web |url=http://www.bedfordresearch.org/politics/humanembryo.php?item=stemcell_lawreview |title=What is an Embryo? Law Review |publisher=Bedford Stem Cell Research Foundation |accessdate=8 November 2012}} 14. ^{{cite web|url=http://www.jbpub.com/catalog/0763743860/ |title=Jones and Bartlett Topics in Biology Series – Human Embryonic Stem Cells, Second Edition Text Book| accessdate=2007-04-13}} 15. ^{{cite web|url=http://www.dph.state.ct.us/StemCell/Committees.htm|title=Connecticut Stem Cell Research Program Committee|accessdate=2007-06-05| archiveurl= https://web.archive.org/web/20070605230843/http://www.dph.state.ct.us/StemCell/Committees.htm| archivedate= 5 June 2007 | deadurl= no}} 16. ^{{cite web|url=http://www.fas.harvard.edu/~research/approvals/escro.html |title=Harvard University's Embryonic Stem Cell Research Oversight Committee |accessdate=2007-06-05 |archiveurl=https://web.archive.org/web/20070702172106/http://fas.harvard.edu/~research/approvals/escro.html |archivedate=2 July 2007 |deadurl=no }} 17. ^{{cite web|url=http://www.childrenshospital.org/cfapps/research/data_admin/Site799/mainpageS799P1sublevel49.html |title=The Stem Cell Program at Children's Hospital Boston |accessdate=2007-06-05 |archiveurl=https://web.archive.org/web/20070927222528/http://www.childrenshospital.org/cfapps/research/data_admin/Site799/mainpageS799P1sublevel49.html |archivedate=2007-09-27 |deadurl=no |df= }} 18. ^{{cite web|url=http://www.asrm.org/Professionals/Meetings/annualmeeting.html|title= The American Society for Reproductive Medicine (ASRM) 2007 Conference}} 19. ^{{cite web|url=http://www.bedfordresearch.org/newsandlibrary/news_article.php?id=24698|title=2009 Jacob Heskel Gabbay Award|accessdate=2009-11-09| archiveurl= https://web.archive.org/web/20091113055902/http://www.bedfordresearch.org/newsandlibrary/news_article.php?id=24698| archivedate= 13 November 2009 | deadurl= no}} 20. ^{{cite web|url=http://www.cwu.edu/~cots/alumni.html|title=COTS 2010 Distinguished Alumni Award|accessdate=2011-07-20| archiveurl= https://web.archive.org/web/20110606122545/http://www.cwu.edu/~cots/alumni.html| archivedate= 6 June 2011 | deadurl= no}} 21. ^{{cite web|url=http://www.nursing.virginia.edu/alumni/awards/|title=2010 Alumni Achievement Award|accessdate=2011-04-23}} 22. ^{{cite web|url=http://www.hivcongress2014.com/program.html|title=2014 Lifetime Achievement Award|accessdate=2014-03-23}} 23. ^{{cite web|url=http://oregonstate.edu/ua/ncs/archives/2014/mar/noted-researcher-speak-osu-commencement-june|title=Noted researcher to speak at OSU commencement in June|accessdate=2014-03-23}} 24. ^{{cite web|url=https://www.youtube.com/watch?v=LNgcD4VRjpI|title= OSU Commencement Address "Stay Involved with Government"|accessdate=2017-06-02}} 25. ^Regalado, A. (2005, Nov 14). Stem-cell rift shows difficulty obtaining eggs. Wall Street Journal. 26. ^By, G. N. (2002, Jan 28). Biotech firms bypass journals to make news. Wall Street Journal. 27. ^By, G. N. (2002, Jan 25). Biotechs rush to announce advances --- but in race to score breakthroughs, companies may be exaggerating. Wall Street Journal. 28. ^By Laurie McGinley and Antonio Regalado. (2001, Nov 27). Bush criticizes firm that clones human embryos, presses for ban. Wall Street Journal. 29. ^By Gautam Naik and Antonio Regalado. (2001, Jul 13). Scientists pursue controversial goal: Cloning for tissue --- resulting cells might cure life-threatening ailments `Perfect solution' or embryo farming? Wall Street Journal. 30. ^By, A. R. (2001, Jul 13). Experiments in controversy --- ethicists, bodyguards monitor scientists' effort to create copy of human embryo. Wall Street Journal. 31. ^Peter Wallsten and, J. R. (2004, Aug 10). THE RACE TO THE WHITE HOUSE; stem cell research gains political life; kerry criticizes bush's limits on the science. and as polls show voters favor less restrictive policies, the president aims to recast his stance. Los Angeles Times. 32. ^Romney, L. (2006, Sep 13). The nation; new battle lines are drawn over egg donation; the issue of whether to pay women to be stem cell research donors has split feminists, causing some to align with christian conservatives. Los Angeles Times. 33. ^Sheryl, G. S. (2001, Dec 09). That scientific breakthrough thing. New York Times. 34. ^Kolata, G. (2002, Apr 30). Parenthood help for men with H.I.V. New York Times. 35. ^Analysis: Egg donation and ethics (2005). . Washington, D.C.: National Public Radio: Science Friday. Wall Street Journal{{reflist|group=WSJ|refs=[25][26][27][28][29][30]}} Los Angeles Times{{reflist|group=LAT|refs=[31][32]}} New York Times{{reflist|group=NYT|refs=[33][34]}} NPR{{reflist|group=NPR|refs=[35]}} References{{reflist}}External links
22 : American inventors|Developmental biologists|Embryologists|HIV/AIDS researchers|Stem cell researchers|Living people|1942 births|American women biologists|Women chemists|Harvard Medical School faculty|Oregon State University alumni|University of Virginia alumni|People from Baker City, Oregon|20th-century American biologists|21st-century biologists|20th-century chemists|21st-century chemists|20th-century American chemists|21st-century American scientists|20th-century women scientists|21st-century women scientists|Women inventors |
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