| 释义 |
- Interactions
- References
- Further reading
- External links
{{Infobox gene}}Baculoviral IAP repeat-containing protein3 (also known as cIAP2) is a protein that in humans is encoded by the BIRC3 gene.[1][2]cIAP2 is a member of the inhibitor of apoptosis family that inhibit apoptosis by interfering with the activation of caspases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. The cIAP2 protein contains three BIR domains, a UBA domain, a CARD domain and a RING finger domain. Transcript variants encoding the same isoform have been identified.[3] InteractionsBaculoviral IAP repeat-containing protein 3 has been shown to interact with: - CASP9,[4]
- RIPK1,[5]
- TRAF1,[6][7]
- TRAF2,[6][7][8][9] and
- UBE2D2.[10]
References1. ^{{cite journal | vauthors = Liston P, Roy N, Tamai K, Lefebvre C, Baird S, Cherton-Horvat G, Farahani R, McLean M, Ikeda JE, MacKenzie A, Korneluk RG | title = Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes | journal = Nature | volume = 379 | issue = 6563 | pages = 349–53 |date=February 1996 | pmid = 8552191 | pmc = | doi = 10.1038/379349a0 }}
2. ^{{cite journal | vauthors = Rothe M, Pan MG, Henzel WJ, Ayres TM, Goeddel DV | title = The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins | journal = Cell | volume = 83 | issue = 7 | pages = 1243–52 |date=February 1996 | pmid = 8548810 | pmc = | doi =10.1016/0092-8674(95)90149-3 }}
3. ^{{cite web | title = Entrez Gene: BIRC3 baculoviral IAP repeat-containing 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=330| accessdate = }}
4. ^{{cite journal | vauthors = Deveraux QL, Roy N, Stennicke HR, Van Arsdale T, Zhou Q, Srinivasula SM, Alnemri ES, Salvesen GS, Reed JC | title = IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases | journal = EMBO J. | volume = 17 | issue = 8 | pages = 2215–23 | year = 1998 | pmid = 9545235 | pmc = 1170566 | doi = 10.1093/emboj/17.8.2215 }}
5. ^{{cite journal | vauthors = Bertrand MJ, Milutinovic S, Dickson KM, Ho WC, Boudreault A, Durkin J, Gillard JW, Jaquith JB, Morris SJ, Barker PA | title = cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination | journal = Mol. Cell | volume = 30 | issue = 6 | pages = 689–700 | year = 2008 | pmid = 18570872 | doi = 10.1016/j.molcel.2008.05.014 }}
6. ^1 {{cite journal | vauthors = Roy N, Deveraux QL, Takahashi R, Salvesen GS, Reed JC | title = The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases | journal = EMBO J. | volume = 16 | issue = 23 | pages = 6914–25 | year = 1997 | pmid = 9384571 | pmc = 1170295 | doi = 10.1093/emboj/16.23.6914 }}
7. ^1 {{cite journal | vauthors = Li X, Yang Y, Ashwell JD | title = TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2 | journal = Nature | volume = 416 | issue = 6878 | pages = 345–7 | year = 2002 | pmid = 11907583 | doi = 10.1038/416345a }}
8. ^{{cite journal | vauthors = Uren AG, Pakusch M, Hawkins CJ, Puls KL, Vaux DL | title = Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 10 | pages = 4974–8 | year = 1996 | pmid = 8643514 | pmc = 39390 | doi = 10.1073/pnas.93.10.4974}}
9. ^{{cite journal | vauthors = Yoneda T, Imaizumi K, Maeda M, Yui D, Manabe T, Katayama T, Sato N, Gomi F, Morihara T, Mori Y, Miyoshi K, Hitomi J, Ugawa S, Yamada S, Okabe M, Tohyama M | title = Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein | journal = J. Biol. Chem. | volume = 275 | issue = 15 | pages = 11114–20 | year = 2000 | pmid = 10753917 | doi = 10.1074/jbc.275.15.11114}}
10. ^{{cite journal | vauthors = Mace PD, Linke K, Feltham R, Schumacher FR, Smith CA, Vaux DL, Silke J, Day CL | title = Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitment | journal = J. Biol. Chem. | volume = 283 | issue = 46 | pages = 31633–40 | year = 2008 | pmid = 18784070 | doi = 10.1074/jbc.M804753200 }}
Further reading{{refbegi}}- {{cite journal | vauthors=Bertoni F, Cavalli F, Cotter FE, Zucca E |title=Genetic alterations underlying the pathogenesis of MALT lymphoma |journal=Hematol. J. |volume=3 |issue= 1 |pages= 10–3 |year= 2003 |pmid= 11960389 |doi= 10.1038/sj.thj.6200146}}
- {{cite journal | vauthors=Uren AG, Pakusch M, Hawkins CJ |title=Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 10 |pages= 4974–8 |year= 1996 |pmid= 8643514 |doi=10.1073/pnas.93.10.4974 | pmc=39390 |display-authors=etal}}
- {{cite journal | vauthors=Rajcan-Separovic E, Liston P, Lefebvre C, Korneluk RG |title=Assignment of human inhibitor of apoptosis protein (IAP) genes xiap, hiap-1, and hiap-2 to chromosomes Xq25 and 11q22-q23 by fluorescence in situ hybridization |journal=Genomics |volume=37 |issue= 3 |pages= 404–6 |year= 1997 |pmid= 8938457 |doi= 10.1006/geno.1996.0579 }}
- {{cite journal | vauthors=Roy N, Deveraux QL, Takahashi R |title=The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases |journal=EMBO J. |volume=16 |issue= 23 |pages= 6914–25 |year= 1998 |pmid= 9384571 |doi= 10.1093/emboj/16.23.6914 | pmc=1170295 |display-authors=etal}}
- {{cite journal | vauthors=Deveraux QL, Roy N, Stennicke HR |title=IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases |journal=EMBO J. |volume=17 |issue= 8 |pages= 2215–23 |year= 1998 |pmid= 9545235 |doi= 10.1093/emboj/17.8.2215 | pmc=1170566 |display-authors=etal}}
- {{cite journal | vauthors=Young SS, Liston P, Xuan JY |title=Genomic organization and physical map of the human inhibitors of apoptosis: HIAP1 and HIAP2 |journal=Mamm. Genome |volume=10 |issue= 1 |pages= 44–8 |year= 1999 |pmid= 9892732 |doi=10.1007/s003359900940 |display-authors=etal}}
- {{cite journal | vauthors=Horrevoets AJ, Fontijn RD, van Zonneveld AJ |title=Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes |journal=Blood |volume=93 |issue= 10 |pages= 3418–31 |year= 1999 |pmid= 10233894 |doi= |display-authors=etal}}
- {{cite journal | vauthors=Suzuki H, Motegi M, Akagi T |title=API1-MALT1-MLT is involved in mucosa-associated lymphoid tissue lymphoma with t(11;18)(q21;q21) |journal=Blood |volume=94 |issue= 9 |pages= 3270–1 |year= 1999 |pmid= 10610122 |doi= |display-authors=etal}}
- {{cite journal | vauthors=Huang H, Joazeiro CA, Bonfoco E |title=The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7 |journal=J. Biol. Chem. |volume=275 |issue= 35 |pages= 26661–4 |year= 2000 |pmid= 10862606 |doi= 10.1074/jbc.C000199200 |display-authors=etal}}
- {{cite journal | vauthors=Verhagen AM, Ekert PG, Pakusch M |title=Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins |journal=Cell |volume=102 |issue= 1 |pages= 43–53 |year= 2000 |pmid= 10929712 |doi=10.1016/S0092-8674(00)00009-X |display-authors=etal}}
- {{cite journal | vauthors=Baens M, Steyls A, Dierlamm J |title=Structure of the MLT gene and molecular characterization of the genomic breakpoint junctions in the t(11;18)(q21;q21) of marginal zone B-cell lymphomas of MALT type |journal=Genes Chromosomes Cancer |volume=29 |issue= 4 |pages= 281–91 |year= 2001 |pmid= 11066071 |doi=10.1002/1098-2264(2000)9999:9999<::AID-GCC1036>3.0.CO;2-I |display-authors=etal}}
- {{cite journal | vauthors=Werneburg BG, Zoog SJ, Dang TT |title=Molecular characterization of CD40 signaling intermediates |journal=J. Biol. Chem. |volume=276 |issue= 46 |pages= 43334–42 |year= 2001 |pmid= 11562359 |doi= 10.1074/jbc.M104994200 |display-authors=etal}}
- {{cite journal | vauthors=Suzuki Y, Imai Y, Nakayama H |title=A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death |journal=Mol. Cell |volume=8 |issue= 3 |pages= 613–21 |year= 2001 |pmid= 11583623 |doi=10.1016/S1097-2765(01)00341-0 |display-authors=etal}}
- {{cite journal | vauthors=Li X, Yang Y, Ashwell JD |title=TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2 |journal=Nature |volume=416 |issue= 6878 |pages= 345–7 |year= 2002 |pmid= 11907583 |doi= 10.1038/416345a }}
- {{cite journal | vauthors=Gordon GJ, Appasani K, Parcells JP |title=Inhibitor of apoptosis protein-1 promotes tumor cell survival in mesothelioma |journal=Carcinogenesis |volume=23 |issue= 6 |pages= 1017–24 |year= 2002 |pmid= 12082024 |doi=10.1093/carcin/23.6.1017 |display-authors=etal}}
- {{cite journal | vauthors=Sharief MK, Noori MA, Zoukos Y |title=Reduced expression of the inhibitor of apoptosis proteins in T cells from patients with multiple sclerosis following interferon-beta therapy |journal=J. Neuroimmunol. |volume=129 |issue= 1–2 |pages= 224–31 |year= 2002 |pmid= 12161039 |doi=10.1016/S0165-5728(02)00185-6 }}
- {{cite journal | vauthors=Ekedahl J, Joseph B, Grigoriev MY |title=Expression of inhibitor of apoptosis proteins in small- and non-small-cell lung carcinoma cells |journal=Exp. Cell Res. |volume=279 |issue= 2 |pages= 277–90 |year= 2002 |pmid= 12243753 |doi=10.1006/excr.2002.5608 |display-authors=etal}}
{{refend}}External links{{PDB Gallery|geneid=330}} 1 : Oncogenes |