| 释义 |
- References
- External links
- Further reading
{{Infobox_gene}}Chemokine (C-C motif) ligand 8 (CCL8), also known as monocyte chemoattractant protein 2 (MCP2), is a protein that in humans is encoded by the CCL8 gene.[1][2]CCL8 is a small cytokine belonging to the CC chemokine family. The CCL8 protein is produced as a precursor containing 109 amino acids, which is cleaved to produce mature CCL8 containing 75 amino acids. The gene for CCL8 is encoded by 3 exons and is located within a large cluster of CC chemokines on chromosome 17q11.2 in humans.[2][3] MCP-2 is chemotactic for and activates many different immune cells, including mast cells, eosinophils and basophils, (that are implicated in allergic responses), and monocytes, T cells, and NK cells that are involved in the inflammatory response.[4][5] CCL8 elicits its effects by binding to several different cell surface receptors called chemokine receptors. These receptors include CCR1, CCR2B, CCR3 and CCR5.[5][6] CCL8 is a CC chemokine that utilizes multiple cellular receptors to attract and activate human leukocytes. CCL8 is a potent inhibitor of HIV1 by virtue of its high-affinity binding to the receptor CCR5, one of the major co-receptors for HIV1.[7] In addition, CCL8 attributes to the growth of metastasis in breast cancer cells. The manipulation of this chemokine activity influences the histology of tumors promoting steps of metastatic processes.[8] CCL8 is also involved in attracting macrophages to the decidua in labor.[9] References1. ^{{cite web | title = Entrez Gene: chemokine (C-C motif) ligand 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6355| accessdate = }}
2. ^1 {{cite journal | vauthors = Van Coillie E, Fiten P, Nomiyama H, Sakaki Y, Miura R, Yoshie O, Van Damme J, Opdenakker G | title = The human MCP-2 gene (SCYA8): cloning, sequence analysis, tissue expression, and assignment to the CC chemokine gene contig on chromosome 17q11.2 | journal = Genomics | volume = 40 | issue = 2 | pages = 323–31 |date=March 1997 | pmid = 9119400 | doi = 10.1006/geno.1996.4594 | url = | issn = }}
3. ^{{cite journal | vauthors = Van Damme J, Proost P, Lenaerts JP, Opdenakker G | title = Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family | journal = J. Exp. Med. | volume = 176 | issue = 1 | pages = 59–65 |date=July 1992 | pmid = 1613466 | pmc = 2119277 | doi = 10.1084/jem.176.1.59| url = | issn = }}
4. ^{{cite journal | vauthors = Proost P, Wuyts A, Van Damme J | title = Human monocyte chemotactic proteins-2 and -3: structural and functional comparison with MCP-1 | journal = J. Leukoc. Biol. | volume = 59 | issue = 1 | pages = 67–74 |date=January 1996 | pmid = 8558070 | doi = | url = | issn = }}
5. ^1 {{cite journal | vauthors = Gong W, Howard OM, Turpin JA, Grimm MC, Ueda H, Gray PW, Raport CJ, Oppenheim JJ, Wang JM | title = Monocyte chemotactic protein-2 activates CCR5 and blocks CD4/CCR5-mediated HIV-1 entry/replication | journal = J. Biol. Chem. | volume = 273 | issue = 8 | pages = 4289–92 |date=February 1998 | pmid = 9468473 | doi = 10.1074/jbc.273.8.4289| url = | issn = }}
6. ^{{cite journal| pmid=29281969 | doi=10.1186/s12865-017-0237-5 | volume=18 | title=Functional expression of CCL8 and its interaction with chemokine receptor CCR3 | pmc=5745793 | year=2017 | journal=BMC Immunol | page=54 | vauthors=Ge B, Li J, Wei Z, Sun T, Song Y, Khan NU}}
7. ^{{PDB|1ESR}}; {{cite journal | vauthors = Blaszczyk J, Coillie EV, Proost P, Damme JV, Opdenakker G, Bujacz GD, Wang JM, Ji X | title = Complete crystal structure of monocyte chemotactic protein-2, a CC chemokine that interacts with multiple receptors | journal = Biochemistry | volume = 39 | issue = 46 | pages = 14075–81 | date=November 2000 | pmid = 11087354 | doi = 10.1021/bi0009340| url = | issn = }}
8. ^{{cite journal| pmc=5112152 | pmid=27181207 | doi=10.1038/onc.2016.161 | volume=35 | title=A CCL8 gradient drives breast cancer cell dissemination | year=2016 | journal=Oncogene | pages=6309–6318 | vauthors=Farmaki E, Chatzistamou I, Kaza V, Kiaris H}}
9. ^{{cite journal| pmid=23451115 | doi=10.1371/journal.pone.0056946 | volume=8 | title=Identification of chemokines associated with the recruitment of decidual leukocytes in human labour: potential novel targets for preterm labour | pmc=3579936 | year=2013 | journal=PLoS One | page=e56946 | vauthors=Hamilton SA, Tower CL, Jones RL}}
External linksFurther reading{{refbegin | 2}}- {{cite journal |vauthors=Struyf S, Proost P, Vandercappellen J |title=Synergistic up-regulation of MCP-2/CCL8 activity is counteracted by chemokine cleavage, limiting its inflammatory and anti-tumoral effects. |journal=Eur. J. Immunol. |volume=39 |issue= 3 |pages= 843–57 |year= 2009 |pmid= 19224633 |doi= 10.1002/eji.200838660 |display-authors=etal}}
- {{cite journal |vauthors=Rom S, Rom I, Passiatore G |title=CCL8/MCP-2 is a target for mir-146a in HIV-1-infected human microglial cells. |journal=FASEB J. |volume=24 |issue= 7 |pages= 2292–300 |year= 2010 |pmid= 20181935 |doi= 10.1096/fj.09-143503 |pmc=2887261|display-authors=etal}}
- {{cite journal |vauthors=Menon R, Pearce B, Velez DR |title=Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants. |journal=Reprod. Biol. Endocrinol. |volume=7 |issue= |pages= 62 |year= 2009 |pmid= 19527514 |doi= 10.1186/1477-7827-7-62 |pmc=2714850|display-authors=etal}}
- {{cite journal |vauthors=Segat L, Brandão LA, Guimarães RL |title=Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. |journal=Vaccine |volume=28 |issue= 10 |pages= 2201–6 |year= 2010 |pmid= 20056178 |doi= 10.1016/j.vaccine.2009.12.056 |display-authors=etal}}
- {{cite journal |vauthors=Rajaraman P, Brenner AV, Butler MA |title=Common variation in genes related to innate immunity and risk of adult glioma. |journal=Cancer Epidemiol. Biomarkers Prev. |volume=18 |issue= 5 |pages= 1651–8 |year= 2009 |pmid= 19423540 |doi= 10.1158/1055-9965.EPI-08-1041 |pmc=2771723|display-authors=etal}}
- {{cite journal |vauthors=Han S, Lan Q, Park AK |title=Polymorphisms in innate immunity genes and risk of childhood leukemia. |journal=Hum. Immunol. |volume=71 |issue= 7 |pages= 727–30 |year= 2010 |pmid= 20438785 |doi= 10.1016/j.humimm.2010.04.004 |pmc=2967770|display-authors=etal}}
- {{cite journal |vauthors=Velez DR, Fortunato SJ, Thorsen P |title=Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants. |journal=PLoS ONE |volume=3 |issue= 9 |pages= e3283 |year= 2008 |pmid= 18818748 |doi= 10.1371/journal.pone.0003283 |pmc=2553267|display-authors=etal}}
- {{cite journal |vauthors=Villa C, Venturelli E, Fenoglio C |title=CCL8/MCP-2 association analysis in patients with Alzheimer's disease and frontotemporal lobar degeneration. |journal=J. Neurol. |volume=256 |issue= 8 |pages= 1379–81 |year= 2009 |pmid= 19415413 |doi= 10.1007/s00415-009-5138-y |display-authors=etal}}
- {{cite journal |vauthors=Siezen CL, Bont L, Hodemaekers HM |title=Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. |journal=Pediatr. Infect. Dis. J. |volume=28 |issue= 4 |pages= 333–5 |year= 2009 |pmid= 19258923 |doi= 10.1097/INF.0b013e31818e2aa9 |display-authors=etal}}
- {{cite journal |vauthors=Vyshkina T, Sylvester A, Sadiq S |title=CCL genes in multiple sclerosis and systemic lupus erythematosus. |journal=J. Neuroimmunol. |volume=200 |issue= 1–2 |pages= 145–52 |year= 2008 |pmid= 18602166 |doi= 10.1016/j.jneuroim.2008.05.016 |display-authors=etal|pmc=5301077 }}
- {{cite journal |vauthors=Ruhwald M, Bodmer T, Maier C |title=Evaluating the potential of IP-10 and MCP-2 as biomarkers for the diagnosis of tuberculosis. |journal=Eur. Respir. J. |volume=32 |issue= 6 |pages= 1607–15 |year= 2008 |pmid= 18684849 |doi= 10.1183/09031936.00055508 |display-authors=etal}}
- {{cite journal |vauthors=Skibola CF, Bracci PM, Halperin E |title=Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma. |journal=PLoS ONE |volume=3 |issue= 7 |pages= e2816 |year= 2008 |pmid= 18636124 |doi= 10.1371/journal.pone.0002816 |pmc=2474696|display-authors=etal}}
- {{cite journal |vauthors=Ockinger J, Stridh P, Beyeen AD |title=Genetic variants of CC chemokine genes in experimental autoimmune encephalomyelitis, multiple sclerosis and rheumatoid arthritis. |journal=Genes Immun. |volume=11 |issue= 2 |pages= 142–54 |year= 2010 |pmid= 19865101 |doi= 10.1038/gene.2009.82 |display-authors=etal}}
- {{cite journal |vauthors=Xie Z, Zhang J, Wu J |title=Upregulation of mitochondrial uncoupling protein-2 by the AMP-activated protein kinase in endothelial cells attenuates oxidative stress in diabetes. |journal=Diabetes |volume=57 |issue= 12 |pages= 3222–30 |year= 2008 |pmid= 18835932 |doi= 10.2337/db08-0610 |pmc=2584127|display-authors=etal}}
- {{cite journal |vauthors=Rajaraman P, Brenner AV, Neta G |title=Risk of meningioma and common variation in genes related to innate immunity. |journal=Cancer Epidemiol. Biomarkers Prev. |volume=19 |issue= 5 |pages= 1356–61 |year= 2010 |pmid= 20406964 |doi= 10.1158/1055-9965.EPI-09-1151 |pmc=3169167|display-authors=etal}}
- {{cite journal |vauthors=Velez DR, Fortunato S, Thorsen P |title=Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants. |journal=Am. J. Obstet. Gynecol. |volume=200 |issue= 2 |pages= 209.e1-27 |year= 2009 |pmid= 19019335 |doi= 10.1016/j.ajog.2008.08.051 |display-authors=etal|pmc=4829203 }}
- {{cite journal |vauthors=Dean RA, Cox JH, Bellac CL |title=Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx. |journal=Blood |volume=112 |issue= 8 |pages= 3455–64 |year= 2008 |pmid= 18660381 |doi= 10.1182/blood-2007-12-129080 |display-authors=etal}}
- {{cite journal |vauthors=Hori T, Naishiro Y, Sohma H |title=CCL8 is a potential molecular candidate for the diagnosis of graft-versus-host disease. |journal=Blood |volume=111 |issue= 8 |pages= 4403–12 |year= 2008 |pmid= 18256320 |doi= 10.1182/blood-2007-06-097287 |pmc=2288733|display-authors=etal}}
- {{cite journal |vauthors=Schuurhof A, Bont L, Siezen CL |title=Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. |journal=Pediatr. Pulmonol. |volume=45 |issue= 6 |pages= 608–13 |year= 2010 |pmid= 20503287 |doi= 10.1002/ppul.21229 |display-authors=etal}}
{{refend}}{{PDB Gallery|geneid=6355}}{{Chemokines}}{{Chemokine receptor modulators}} 1 : Cytokines |