“Chlamydia muridarum”的意思、由来-开放百科全书

Chlamydia muridarum is an intracellular bacterial species that at one time belonged to Chlamydia trachomatis. However, C. trachomatis naturally only infects humans and C. muridarum naturally infects only members of the family Muridae (includes both mice and hamsters, Alderton, 1996).

Two strains of Chlamydia muridarum, MoPn (originally named Nigg) and SFPD,^[2] have been isolated from mice and hamsters. Glycogen production by both strains has been demonstrated. The chromosome and extrachromosomal plasmid of MoPn have been sequenced.

Chlamydia muridarum MoPn binds mAbs recognizing Chlamydia trachomatis MOMP vs4 core epitope (T)LNPT(IA).^[3] DNA sequence analysis indicates that these mAbs should recognize SFPD and that Chlamydia trachomatis B-serogroup mAbs specific for the vs4 epitope IAGAG should recognize SFPD.^[4] MoPn was isolated in 1942 from the lungs of asymptomatic albino Swiss mice and was subsequently shown to be capable of producing disease in mice.^[5] SFPD was obtained from a hamster, concurrent with a causative agent of proliferative ileitis. MoPn has been shown to be sensitive to sulfadiazine.

Genome structure

References

1. ^{{cite journal|last1=Everett|first1=K. D. E.|last2=Bush|first2=R. M.|last3=Andersen|first3=A. A.|title=Emended description of the order Chlamydiales, proposal of Parachlamydiaceae fam. nov. and Simkaniaceae fam. nov., each containing one monotypic genus, revised taxonomy of the family Chlamydiaceae, including a new genus and five new species, and standards for the identification of organisms|journal=International Journal of Systematic Bacteriology|volume=49|issue=2|year=1999|pages=415–440|issn=0020-7713|doi=10.1099/00207713-49-2-415|pmid=10319462}}
2. ^{{Cite journal | last1 = Zhang | first1 = YX. | last2 = Fox | first2 = JG. | last3 = Ho | first3 = Y. | last4 = Zhang | first4 = L. | last5 = Stills | first5 = HF. | last6 = Smith | first6 = TF. | title = Comparison of the major outer-membrane protein (MOMP) gene of mouse pneumonitis (MoPn) and hamster SFPD strains of Chlamydia trachomatis with other Chlamydia strains. | journal = Mol Biol Evol | volume = 10 | issue = 6 | pages = 1327–42 |date=Nov 1993 | doi = 10.1093/oxfordjournals.molbev.a040079| pmid = 8277858 }}
3. ^{{Cite journal | last1 = Peterson | first1 = EM. | last2 = Cheng | first2 = X. | last3 = Markoff | first3 = BA. | last4 = Fielder | first4 = TJ. | last5 = de la Maza | first5 = LM. | title = Functional and structural mapping of Chlamydia trachomatis species-specific major outer membrane protein epitopes by use of neutralizing monoclonal antibodies. | journal = Infect Immun | volume = 59 | issue = 11 | pages = 4147–53 |date=Nov 1991 | doi = | pmid = 1718870 | pmc=259009}}
4. ^{{Cite journal | last1 = Batteiger | first1 = BE. | last2 = Lin | first2 = PM. | last3 = Jones | first3 = RB. | last4 = Van Der Pol | first4 = BJ. | title = Species-, serogroup-, and serovar-specific epitopes are juxtaposed in variable sequence region 4 of the major outer membrane proteins of some Chlamydia trachomatis serovars. | journal = Infect Immun | volume = 64 | issue = 7 | pages = 2839–41 |date=Jul 1996 | doi = | pmid = 8698520 | pmc=174151}}
5. ^{{Cite journal | last1 = Nigg | first1 = C. | title = AN UNIDENTIFIED VIRUS WHICH PRODUCES PNEUMONIA AND SYSTEMIC INFECTION IN MICE. | journal = Science | volume = 95 | issue = 2454 | pages = 49–50 |date=Jan 1942 | doi = 10.1126/science.95.2454.49-a | pmid = 17773453 }}
6. ^{{cite journal | journal=Nucleic Acids Res | volume=28 | pages=1397–406 | year=2000 | author=Read TD | title=Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39 | url=http://nar.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=10684935 | pmid=10684935 | doi = 10.1093/nar/28.6.1397 | issue=6 | pmc=111046 |name-list-format=vanc | display-authors=1 | last2=Brunham | first2=RC | last3=Shen | first3=C | last4=Gill | first4=SR | last5=Heidelberg | first5=JF | last6=White | first6=O | last7=Hickey | first7=EK | last8=Peterson | first8=J | last9=Utterback | first9=T }}

Genome structure

References

Further reading

External links