| 词条 | C-myc internal ribosome entry site (IRES) |
| 释义 |
| Name = c-myc internal ribosome entry site (IRES) | image = RF00216.jpg | width = | caption = Predicted secondary structure and sequence conservation of IRES_c-myc | Symbol = IRES_c-myc | AltSymbols = c-myc_IRES | Rfam = RF00216 | miRBase = | miRBase_family = | RNA_type = Cis-reg; IRES | Tax_domain = Eukaryota | GO = {{GO|0043022}} | SO = {{SO|0000243}} | CAS_number = | EntrezGene = | HGNCid = | OMIM = | PDB = | RefSeq = | Chromosome = | Arm = | Band = | LocusSupplementaryData = }} The c-myc internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of C-myc and allows cap-independent translation. The mammalian c-myc gene is a proto-oncogene which is required for cell proliferation, transformation and death. c-myc mRNA has an alternative method of translation via internal ribosome entry where ribosomes are recruited to the IRES located in the 5' UTR thus bypassing the typical eukaryotic cap-dependent translation pathway.[1] References1. ^{{cite journal | last = Le Quesne | first = JP |author2=Stoneley M |author3=Fraser GA |author4=Willis AE | year = 2001 | title = Derivation of a structural model for the c-myc IRES | journal = J Mol Biol | volume = 310 | pages = 111–126 | pmid = 11419940 | doi = 10.1006/jmbi.2001.4745 | issue = 1}} External links
1 : Cis-regulatory RNA elements |
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