CPS2 may refer to:

• CP System II, the Capcom Play System 2
• Carbamoyl Phosphate Synthase II, the rate-limiting enzyme of pyrimidine biosynthesis
• Keene/Elmhirst's Resort Airport, Transport Canada airport code CPS2
• Control Performance Standard 2, North American Electric Reliability Corporation Frequency Control Performance Measure

• Draft:Nations Capital Swim Club
• Draft:Nationwide League (Kenya Rugby Union)
• Draft:Native American drama
• Draft:Native American Kenpo Council
• Draft:Native American Opposition to the Indian Citizenship Act
• Draft:Native American Research Center for Health (NARCH)
• Draft:Native American Voting Rights Act of 2018
• Draft:Native Art Department International
• Draft:Native Arts and Cultures Foundation
• Draft:Native Authority (Nyasaland)
• Draft:Native Construct
• Draft:Native Design
• Draft:Native Eyewear
• Draft:NativeScript
• Draft:Nativity (film series)
• Draft:NATO Defense College Foundation
• Draft:Natoora
• Draft:NATO Science and Technology Organization
• Draft:Natos y Waor
• Draft:NATS Messaging
• Draft:Natsumi Hayashi
• Draft:Nattarangu
• Draft:Natti Natti Valbo
• Draft:Nattr
• Draft:Nattskiftet