“CXCL9”的意思、由来-开放百科全书

Neutrophil collagenase/matrix metalloproteinase 8 (MMP-8) degrades CXCL9 and cleaves CXCL10 at two positions.

Gelatinase B/matrix metalloproteinase 9 (MMP-9) degrades CXCL10 and cleaves CXCL9 at three different sites in its extended carboxy-terminal region.

Biomarkers

CXCL9, -10, -11 have proven to be valid biomarkers for the development of heart failure and left ventricular dysfunction, suggesting an underlining pathophysiological relation between levels of these chemokines and the development of adverse cardiac remodeling.^[4]^[5]

This chemokine has also been associated as a biomarker for diagnosing Q fever infections.^[6]

Interactions

References

1. ^{{cite journal | vauthors = Lee HH, Farber JM | title = Localization of the gene for the human MIG cytokine on chromosome 4q21 adjacent to INP10 reveals a chemokine "mini-cluster" | journal = Cytogenetics and Cell Genetics | volume = 74 | issue = 4 | pages = 255–8 | year = 1996 | pmid = 8976378 | doi = 10.1159/000134428 }}
2. ^{{cite journal | vauthors = O'Donovan N, Galvin M, Morgan JG | title = Physical mapping of the CXC chemokine locus on human chromosome 4 | journal = Cytogenetics and Cell Genetics | volume = 84 | issue = 1–2 | pages = 39–42 | year = 1999 | pmid = 10343098 | doi = 10.1159/000015209 }}
3. ^{{cite journal | vauthors = Tensen CP, Flier J, Van Der Raaij-Helmer EM, Sampat-Sardjoepersad S, Van Der Schors RC, Leurs R, Scheper RJ, Boorsma DM, Willemze R | title = Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3) | journal = The Journal of Investigative Dermatology | volume = 112 | issue = 5 | pages = 716–22 | date = May 1999 | pmid = 10233762 | doi = 10.1046/j.1523-1747.1999.00581.x }}
4. ^{{cite journal | vauthors = Altara R, Gu YM, Struijker-Boudier HA, Thijs L, Staessen JA, Blankesteijn WM | title = Left Ventricular Dysfunction and CXCR3 Ligands in Hypertension: From Animal Experiments to a Population-Based Pilot Study | journal = PLOS ONE | volume = 10 | issue = 10 | pages = e0141394 | date = 2015 | pmid = 26506526 | doi = 10.1371/journal.pone.0141394 | pmc=4624781}}
5. ^{{cite journal | vauthors = Altara R, Manca M, Hessel MH, Gu Y, van Vark LC, Akkerhuis KM, Staessen JA, Struijker-Boudier HA, Booz GW, Blankesteijn WM | title = CXCL10 Is a Circulating Inflammatory Marker in Patients with Advanced Heart Failure: a Pilot Study | journal = Journal of Cardiovascular Translational Research | volume = 9 | issue = 4 | pages = 302–14 | date = August 2016 | pmid = 27271043 | doi = 10.1007/s12265-016-9703-3 }}
6. ^{{cite journal |vauthors = ((Jansen AFM)), Schoffelen T, Textoris J, Mege JL, Nabuurs-Franssen M, ((Raijmakers RPH)), Netea MG, ((Joosten LAB)), Bleeker-Rovers CP, van Deuren M |title = CXCL9, a promising biomarker in the diagnosis of chronic Q fever |journal = BMC Infect. Dis. |volume = 17 |issue = 1 |pages = 556 |year = 2017 |pmid = 28793883 |pmc = 5551022 |doi = 10.1186/s12879-017-2656-6 }}
7. ^{{cite journal | vauthors = Lasagni L, Francalanci M, Annunziato F, Lazzeri E, Giannini S, Cosmi L, Sagrinati C, Mazzinghi B, Orlando C, Maggi E, Marra F, Romagnani S, Serio M, Romagnani P | title = An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4 | journal = The Journal of Experimental Medicine | volume = 197 | issue = 11 | pages = 1537–49 | date = June 2003 | pmid = 12782716 | pmc = 2193908 | doi = 10.1084/jem.20021897 }}
8. ^{{cite journal | vauthors = Weng Y, Siciliano SJ, Waldburger KE, Sirotina-Meisher A, Staruch MJ, Daugherty BL, Gould SL, Springer MS, DeMartino JA | title = Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors | journal = The Journal of Biological Chemistry | volume = 273 | issue = 29 | pages = 18288–91 | date = July 1998 | pmid = 9660793 | doi = 10.1074/jbc.273.29.18288 }}

Further reading

{{cite journal | vauthors = Farber JM | title = A macrophage mRNA selectively induced by gamma-interferon encodes a member of the platelet factor 4 family of cytokines | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 87 | issue = 14 | pages = 5238–42 | date = July 1990 | pmid = 2115167 | pmc = 54298 | doi = 10.1073/pnas.87.14.5238 }}

{{cite journal | vauthors = Liao F, Rabin RL, Yannelli JR, Koniaris LG, Vanguri P, Farber JM | title = Human Mig chemokine: biochemical and functional characterization | journal = The Journal of Experimental Medicine | volume = 182 | issue = 5 | pages = 1301–14 | date = November 1995 | pmid = 7595201 | pmc = 2192190 | doi = 10.1084/jem.182.5.1301 }}

{{cite journal | vauthors = Farber JM | title = HuMig: a new human member of the chemokine family of cytokines | journal = Biochemical and Biophysical Research Communications | volume = 192 | issue = 1 | pages = 223–30 | date = April 1993 | pmid = 8476424 | doi = 10.1006/bbrc.1993.1403 }}

{{cite journal | vauthors = Erdel M, Laich A, Utermann G, Werner ER, Werner-Felmayer G | title = The human gene encoding SCYB9B, a putative novel CXC chemokine, maps to human chromosome 4q21 like the closely related genes for MIG (SCYB9) and INP10 (SCYB10) | journal = Cytogenetics and Cell Genetics | volume = 81 | issue = 3–4 | pages = 271–2 | year = 1998 | pmid = 9730616 | doi = 10.1159/000015043 }}

{{cite journal | vauthors = Jenh CH, Cox MA, Kaminski H, Zhang M, Byrnes H, Fine J, Lundell D, Chou CC, Narula SK, Zavodny PJ | title = Cutting edge: species specificity of the CC chemokine 6Ckine signaling through the CXC chemokine receptor CXCR3: human 6Ckine is not a ligand for the human or mouse CXCR3 receptors | journal = Journal of Immunology | volume = 162 | issue = 7 | pages = 3765–9 | date = April 1999 | pmid = 10201891 | doi = }}

{{cite journal | vauthors = Rabin RL, Park MK, Liao F, Swofford R, Stephany D, Farber JM | title = Chemokine receptor responses on T cells are achieved through regulation of both receptor expression and signaling | journal = Journal of Immunology | volume = 162 | issue = 7 | pages = 3840–50 | date = April 1999 | pmid = 10201901 | doi = }}

{{cite journal | vauthors = Shields PL, Morland CM, Salmon M, Qin S, Hubscher SG, Adams DH | title = Chemokine and chemokine receptor interactions provide a mechanism for selective T cell recruitment to specific liver compartments within hepatitis C-infected liver | journal = Journal of Immunology | volume = 163 | issue = 11 | pages = 6236–43 | date = December 1999 | pmid = 10570316 | doi = }}

{{cite journal | vauthors = Jinquan T, Jing C, Jacobi HH, Reimert CM, Millner A, Quan S, Hansen JB, Dissing S, Malling HJ, Skov PS, Poulsen LK | title = CXCR3 expression and activation of eosinophils: role of IFN-gamma-inducible protein-10 and monokine induced by IFN-gamma | journal = Journal of Immunology | volume = 165 | issue = 3 | pages = 1548–56 | date = August 2000 | pmid = 10903763 | doi = 10.4049/jimmunol.165.3.1548 }}

{{cite journal | vauthors = Loetscher P, Pellegrino A, Gong JH, Mattioli I, Loetscher M, Bardi G, Baggiolini M, Clark-Lewis I | title = The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3 | journal = The Journal of Biological Chemistry | volume = 276 | issue = 5 | pages = 2986–91 | date = February 2001 | pmid = 11110785 | doi = 10.1074/jbc.M005652200 }}

{{cite journal | vauthors = Romagnani P, Annunziato F, Lazzeri E, Cosmi L, Beltrame C, Lasagni L, Galli G, Francalanci M, Manetti R, Marra F, Vanini V, Maggi E, Romagnani S | title = Interferon-inducible protein 10, monokine induced by interferon gamma, and interferon-inducible T-cell alpha chemoattractant are produced by thymic epithelial cells and attract T-cell receptor (TCR) alphabeta+ CD8+ single-positive T cells, TCRgammadelta+ T cells, and natural killer-type cells in human thymus | journal = Blood | volume = 97 | issue = 3 | pages = 601–7 | date = February 2001 | pmid = 11157474 | doi = 10.1182/blood.V97.3.601 }}

{{cite journal | vauthors = Dwinell MB, Lügering N, Eckmann L, Kagnoff MF | title = Regulated production of interferon-inducible T-cell chemoattractants by human intestinal epithelial cells | journal = Gastroenterology | volume = 120 | issue = 1 | pages = 49–59 | date = January 2001 | pmid = 11208713 | doi = 10.1053/gast.2001.20914 }}

{{cite journal | vauthors = Lambeir AM, Proost P, Durinx C, Bal G, Senten K, Augustyns K, Scharpé S, Van Damme J, De Meester I | title = Kinetic investigation of chemokine truncation by CD26/dipeptidyl peptidase IV reveals a striking selectivity within the chemokine family | journal = The Journal of Biological Chemistry | volume = 276 | issue = 32 | pages = 29839–45 | date = August 2001 | pmid = 11390394 | doi = 10.1074/jbc.M103106200 }}

{{cite journal | vauthors = Stoof TJ, Flier J, Sampat S, Nieboer C, Tensen CP, Boorsma DM | title = The antipsoriatic drug dimethylfumarate strongly suppresses chemokine production in human keratinocytes and peripheral blood mononuclear cells | journal = The British Journal of Dermatology | volume = 144 | issue = 6 | pages = 1114–20 | date = June 2001 | pmid = 11422029 | doi = 10.1046/j.1365-2133.2001.04220.x }}

{{cite journal | vauthors = Campbell JD, Stinson MJ, Simons FE, Rector ES, HayGlass KT | title = In vivo stability of human chemokine and chemokine receptor expression | journal = Human Immunology | volume = 62 | issue = 7 | pages = 668–78 | date = July 2001 | pmid = 11423172 | doi = 10.1016/S0198-8859(01)00260-9 }}

{{cite journal | vauthors = Scapini P, Laudanna C, Pinardi C, Allavena P, Mantovani A, Sozzani S, Cassatella MA | title = Neutrophils produce biologically active macrophage inflammatory protein-3alpha (MIP-3alpha)/CCL20 and MIP-3beta/CCL19 | journal = European Journal of Immunology | volume = 31 | issue = 7 | pages = 1981–8 | date = July 2001 | pmid = 11449350 | doi = 10.1002/1521-4141(200107)31:7<1981::AID-IMMU1981>3.0.CO;2-X }}

{{cite journal | vauthors = Gillitzer R | title = Inflammation in human skin: a model to study chemokine-mediated leukocyte migration in vivo | journal = The Journal of Pathology | volume = 194 | issue = 4 | pages = 393–4 | date = August 2001 | pmid = 11523044 | doi = 10.1002/1096-9896(200108)194:4<393::AID-PATH907>3.0.CO;2-7 }}

{{cite journal | vauthors = Romagnani P, Rotondi M, Lazzeri E, Lasagni L, Francalanci M, Buonamano A, Milani S, Vitti P, Chiovato L, Tonacchera M, Bellastella A, Serio M | title = Expression of IP-10/CXCL10 and MIG/CXCL9 in the thyroid and increased levels of IP-10/CXCL10 in the serum of patients with recent-onset Graves' disease | journal = The American Journal of Pathology | volume = 161 | issue = 1 | pages = 195–206 | date = July 2002 | pmid = 12107104 | pmc = 1850693 | doi = 10.1016/S0002-9440(10)64171-5 }}

1 : Cytokines

Biomarkers

Interactions

References

External links

Further reading