E80 can refer to:

• European route E80
• King's Indian Defense, Encyclopaedia of Chess Openings code
• Toyota Corolla (E80), a car

• Gruemberger (crater)
• Grue (monster)
• Gruenderzeit
• Gruenfeld Defence
• Gruenfeld Defense
• Gruenfeld defense
• Gruenkern
• Grue, Norway
• Gruen transfer
• Gruesome Gertie
• Gruesome Twosome
• Gruetli-Laager, Tennessee
• Gruetli-Laager, TN
• Gruey
• Gruff
• Gruffalo
• Gruffi
• Gruff Rhys
• Gruffudd ap Cynan
• Gruffydd ap Llywelyn
• Gruffydd ap Llywelyn Fawr
• Gruffydd ap Rhys
• Gruffydd Robert
• Grugan Township, Clinton County, Pennsylvania
• Grugan Township, PA