CB2 may refer to:

• Cannabinoid receptor type 2
• Cortex Strikes Back, a video game developed by Naughty Dog for PlayStation
• CB2, a division of Crate & Barrel
• Child-robot with Biomimetic Body - a Robot at the Osaka University that mimics infant learning.

• The unanswerable questions
• The Unanswered Question (lecture series)
• The Unauthorized Autobiography of Samantha Brown
• The Unauthorized Saved by the Bell Story
• The Unbearable Lightness of Being a Dickhead
• The Unbearable Lightness of Being a Prawn Cracker
• The Unbearable Lightness of Inspector Fan
• The Unbearable Like-Likeness of Gene
• The Unbeatables (2013)
• The Unbeatables (film)
• The Unbeatable Squirrel Girl
• The Unbelievable Guitar and Voice of Jerry Reed
• The Unbelievables
• The Unbelievable Truth
• The Unbelievable Truth (disambiguation)
• The Unbelievable Truth (TV series)
• The Unbeliever
• The Unbelievers
• The Unbelievers (film)
• The Unblinking Eye (Everything Is Broken)
• The Unbrave One
• The Uncanny (1977 film)
• The Uncanny (disambiguation)
• The UNC Department of Public Policy
• The Uncertainty Principle (audio drama)