“Cephamycin”的意思、由来-开放百科全书

Cephamycins are a group of beta-lactam antibiotics. They are very similar to cephalosporins, and the cephamycins are sometimes classified as cephalosporins.

Like cephalosporins, cephamycins are based upon the cephem nucleus. Unlike most cephalosporins, cephamycins are a very efficient antibiotic against anaerobic microbes.

Cephamycins were originally produced by Streptomyces, but synthetic ones have been produced as well.

In addition, cephamycins have been shown to be stable against extended-spectrum beta-lactamase (ESBL) producing organisms, although their use in clinical practice is lacking for this indication.

Examples

References

1. ^{{cite book |author=Oreste A. Mascaretti |title=Bacteria Versus Antibacterial Agents: An Integrated Approach |publisher=American Society Microbiology |location= |year=2003 |pages=144 |isbn=1-55581-258-9 |oclc= |doi= |accessdate=}}
2. ^{{cite journal |vauthors=Little PJ, Peddie BA |title=Clinical use of cefoxitin, a new semisynthetic cephamycin |journal=N. Z. Med. J. |volume=88 |issue=616 |pages=46–9 |date=July 1978 |pmid=279853 |doi= |url=}}
3. ^{{cite journal |vauthors=Clarke AM, Zemcov SJ |title=Antibacterial activity of the cephamycin cefotetan: an in-vitro comparison with other beta-lactam antibiotics |journal=J. Antimicrob. Chemother. |volume=Suppl |issue= |pages=67–72 |series=11 |date=January 1983 |pmid=6404881 |doi= 10.1093/jac/11.suppl_A.67}}
4. ^{{cite journal |vauthors=Benlloch M, Torres A, Soriano F |title=Cefmetazole (CS-1170): a new cephamycin with activity against gram-negative bacilli and staphylococci |journal=J. Antimicrob. Chemother. |volume=10 |issue=4 |pages=347–50 |date=October 1982 |pmid=6958672 |doi= 10.1093/jac/10.4.347|url=http://jac.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=6958672}}