词条 | Ephedra (plant) |
释义 |
| image = Pollença - Ma-2210 - Cap de Formentor - Ephedra fragilis 05 ies.jpg | image_caption = Ephedra fragilis in Mallorca | grandparent_authority = Dumort.[1] | parent_authority = Dumort.[2] | taxon = Ephedra | authority = L.[2] | synonyms_ref = [4] | synonyms = Chaetocladus Nelson 1866 nom. illeg. | range_map = Ephedra distribution.PNG | range_map_alt = Map showing the range of Ephedra | range_map_caption = Global range of Ephedra }}Ephedra is a genus of gymnosperm shrubs, the only genus in its family, Ephedraceae, and order, Ephedrales. The various species of Ephedra are widespread in many lands, native to southwestern North America, southern Europe, northern Africa, southwest and central Asia, northern China and western South America.[3] In temperate climates, most Ephedra species grow on shores or in sandy soils with direct sun exposure. Common names in English include joint-pine, jointfir, Mormon-tea or Brigham tea. The Chinese name for Ephedra species is mahuang ({{zh|s=麻黄|t=麻黃|p=máhuáng|w=ma-huang|l=hemp yellow}}). Ephedra is also sometimes called sea grape (from the French {{lang|fr|raisin de mer}}), a common name for the flowering plant Coccoloba uvifera.{{fact|date=December 2018}}{{dubious|date=December 2018}} Medical uses{{main|Ephedra}}Plants of the genus Ephedra, including E. sinica and others, have traditionally been used by indigenous people for a variety of medicinal purposes, including treatment of asthma, hay fever and the common cold.[4] The alkaloids ephedrine and pseudoephedrine are active constituents of E. sinica and other members of the genus. These compounds are sympathomimetics with stimulant and decongestant qualities and are chemically substituted amphetamines. Pollen of Ephedra spp. was found in the Shanidar IV burial site in Iraq, which led to the suggestion that its use as a medicinal plant dates to over 60,000 years ago.[5] Paul B. Pettitt has stated that "[a] recent examination of the microfauna from the strata into which the grave was cut suggests that the pollen was deposited by the burrowing rodent Meriones persicus, which is common in the Shanidar microfauna and whose burrowing activity can be observed today".[6] It has been suggested that Ephedra may be the soma plant of Indo-Iranian religion.[7] Adverse effectsAlkaloids obtained from the species of Ephedra used in herbal medicines, which are used to synthetically prepare pseudoephedrine and ephedrine, can cause cardiovascular events. These events have been associated with arrhythmias, palpitations, tachycardia and myocardial infarction. Caffeine consumption in combination with ephedrine has been reported to increase the risk of these cardiovascular events.[8] SpeciesAccepted species:[9]
Economic botany and alkaloid contentEarliest uses of Ephedra spp. (mahuang) for specific illnesses date back to 5000 BC. Ephedrine and isomers were already isolated in 1881 from Ephedra dystachia and characterized by the Japanese organic chemist Nagai Nagayoshi of the 19th century. His work to access Ephedra drug materials to isolate a pure pharmaceutical substance, and the systematic production of semi-synthetic derivatives thereof is relevant still today as the three species Ephedra sinica, Ephedra vulgaris and to a lesser extent Ephedra equisetina are commercially grown in Mainland China as a source for natural ephedrines and isomers for use in pharmacy. E. sinica and E. vulgaris usually carry six optically active phenylethylamines, mostly ephedrine and pseudoephedrine with minor amounts of norephedrine, norpseudoephedrine as well as the three methylated analogs. Reliable information on the total alkaloid content of the crude drug is difficult to obtain. Based on HPLC analyses in industrial settings, the concentrations of total alkaloids in dried Herba Ephedra ranged between 1 and 4%, and in some cases up to 6%.[11] For a review of the alkaloid distribution in different species of the genus Ephedra see Jian-fang Cui (1991).[12] Other American and European species of Ephedra, e.g. Ephedra nevadensis (Nevada Mormon tea) have not been systematically assayed; based on unpublished field investigations, they contain very low levels (less than 0.1%) or none at all.[13] References1. ^{{cite web |url=http://www.eu-nomen.eu/portal/taxon.php?GUID=1E4EB308-C14C-49A9-8D0A-A2D3F4C4223F |title=Ephedrales Dumort. |work=EU-NOMEN |accessdate=20 January 2016}} 2. ^1 {{cite book|title=The Families and Genera of Vascular Plants, Vol. 1: Pteridophytes and Gymnosperms|year=1990|publisher=Springer-Verlag|location=Berlin|isbn=3540517944|pages=379–381|authors=Kramer, K.U.; (illustrations), P.S. Green ; assisted by E. Götz|editor1=Kramer, K.U. |editor2=Green, P.S. }} 3. ^1 Kew World Checklist of Selected Plant Families 4. ^{{cite journal |vauthors=Abourashed E, El-Alfy A, Khan I, Walker L |title=Ephedra in perspective—a current review |journal=Phytother Res |volume=17 |issue=7 |pages=703–12 |year=2003 |pmid=12916063 |doi=10.1002/ptr.1337}} 5. ^{{cite journal|author=Solecki, Ralph S. |title=Shanidar IV, a Neanderthal Flower Burial in Northern Iraq|doi=10.1126/science.190.4217.880|journal= Science |volume= 190|issue=4217 |year= 1975|pages= 880–881|jstor=1741776}} 6. ^{{cite journal |author=Paul B. Pettitt |year=2002 |title=The Neanderthal dead: exploring mortuary variability in Middle Palaeolithic Eurasia |journal=Before Farming |volume=1 |issue=4 |pages=1–26}} 7. ^{{cite book|last=Rudgley|first=Richard|title=The Alchemy of Culture|year=1993|publisher=British Museum Press|location=London|isbn=0-7141-2711-6|pages=44–45}} 8. ^{{cite journal|last1=Skalli|first1=Souad|last2=Zaid|first2=Abdelhamid|last3=Soulaymani|first3=Rachida|title=Drug Interactions With Herbal Medicines|journal=Ther Drug Monit|date=December 2007|volume=29|issue=6|pages=1–8}} 9. ^Kew World Checklist of Selected Plant Families 10. ^https://www.banglajol.info/index.php/BJPT/article/view/30850 11. ^Brossi, Arnold (ed) (1989), [https://books.google.com/books?id=aQ16om_WW60C&pg=PA106 The Alkaloids: Chemistry and Pharmacology], Vol. 35, {{ISBN|0-12-469535-3}}. 12. ^{{cite journal|author=Cui, Jian-fang|title= Analysis of alkaloids in Chinese Ephedra species by GC methods|doi=10.1002/pca.2800020305|journal=Phytochemical Analysis|volume= 2|issue =3| pages=116–119|year= 1991|display-authors=etal}} 13. ^Hegnauer R. (1962) "Chemotaxonomie der Pflanzen. I". Birkhauser Verlag, Basel; Switzerland, pp. 460–462 as cited in {{cite journal|pmid=15084081|journal=J AOAC Int. |year=2004 |volume=87|issue=1|pages=1–14|author=Roman MC|title=Determination of ephedrine alkaloids in botanicals and dietary supplements by HPLC-UV: collaborative study|pmc=2584348}} External links{{Commons category|Ephedraceae}}
6 : Gymnosperm genera|Ephedraceae|Medicinal plants|Plants used in traditional Chinese medicine|Extant Early Cretaceous first appearances|Aptian genus first appearances |
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