| 词条 | Flosequinan |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 444453345 | IUPAC_name = (RS)-7-fluoro-3-methanesulfinyl-1-methyl-1,4-dihydroquinolin-4-one | image = Flosequinan.svg | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 76568-02-0 | ATC_prefix = C01 | ATC_suffix = DB01 | PubChem = 4474062 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 6NB119DLU7 | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D04195 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 3672315 | smiles = CN1C=C(C(=O)C2=C1C=C(C=C2)F)S(=O)C | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C11H10FNO2S/c1-13-6-10(16(2)15)11(14)8-4-3-7(12)5-9(8)13/h3-6H,1-2H3 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = UYGONJYYUKVHDD-UHFFFAOYSA-N | C=11 | H=10 | F=1 | N=1 | O=2 | S=1 | molecular_weight = 239.267 g/mol }}Flosequinan is a quinolone vasodilator that was discovered and developed by Boots UK and was sold for about a year under the trade name Manoplax. It had been approved in 1992 in the US and UK to treat people with heart failure who could not tolerate ACE inhibitors or digitalis.[1] Boots initiated a clinical trial called PROFILE to see if the drug could be useful in a wider population. The study was terminated early in 1993 due to increased mortality in the drug arm of the trial; preliminary results were published in a conference abstract by the PI Milton Packer and others, which promised data and analysis would be forthcoming in a future paper, but as of 2001 no such paper had been published.[2] Boots withdrew it from the market in July 1993.[1][3] References1. ^1 {{cite news|last1=Hosking|first1=Patrick|title=Manoplax: from heart to heartbreak: With millions lost on its 'wonder|url=https://www.independent.co.uk/news/business/manoplax-from-heart-to-heartbreak-with-millions-lost-on-its-wonder-drug-patrick-hosking-asks-whether-1487095.html|work=The Independent|date=25 July 1993}} {{Vasodilators used in cardiac diseases}}{{cardiovascular-drug-stub}}2. ^{{cite journal|last1=van Veldhuisen|first1=DJ|last2=Poole-Wilson|first2=PA|title=The underreporting of results and possible mechanisms of 'negative' drug trials in patients with chronic heart failure.|journal=International Journal of Cardiology|date=August 2001|volume=80|issue=1|pages=19–27|pmid=11532543}} 3. ^{{cite news|last1=Associated Press|title=Heart Failure Drug Manoplax Taken Off Market|url=http://www.apnewsarchive.com/1993/Heart-Failure-Drug-Manoplax-Taken-Off-Market/id-41d97c60a47c8e296bb592d042586dc2|work=AP News Archive|date=July 19, 1993}} 5 : Withdrawn drugs|Vasodilators|4-Quinolones|Sulfoxides|Fluoroarenes |
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