| 词条 | Ghon focus |
| 释义 |
A Ghon focus is a primary lesion usually subpleural, often in the mid to lower zones, caused by Mycobacterium bacilli (tuberculosis) developed in the lung of a nonimmune host (usually a child).[1] It is named for Anton Ghon (1866–1936), an Austrian pathologist. It is a small area of granulomatous inflammation, only detectable by chest X-ray if it calcifies or grows substantially (see tuberculosis radiology).[2] Typically these will heal, but in some cases, especially in immunosuppressed patients, it will progress to miliary tuberculosis (so named due to the granulomas resembling millet seeds on a chest X-ray).[2] The classical location for primary infection is surrounding the lobar fissures, either in the upper part of the lower lobe or lower part of the upper lobe.[2] If the Ghon focus also involves infection of adjacent lymphatics and hilar lymph nodes, it is known as the Ghon's complex or primary complex. When a Ghon's complex undergoes fibrosis and calcification it is called a Ranke complex.[2][3] References1. ^{{cite book|last1=Braun|first1=Carie Ann|last2=Anderson|first2=Cindy Miller|title=Pathophysiology: Functional Alterations in Human Health|date=2007|publisher=Lippincott Williams & Wilkins|isbn=9780781762502|page=326|url=https://books.google.com/books?id=hRoRff4PH6wC&dq=Ghon+focus&source=gbs_navlinks_s|accessdate=13 November 2017|language=en}} {{Gram-positive actinobacteria diseases}}{{pathology-stub}}2. ^1 2 3 Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; & Mitchell, Richard N. (2007). Robbins Basic Pathology (8th ed.). Saunders Elsevier. pp. 516-522 {{ISBN|978-1-4160-2973-1}} 3. ^{{cite web | url=http://www.smbs.buffalo.edu/pth600/IMC-Path/y2case/y2ans10.htm | title=Pathology Image Gallery: Answers to Case 10 | archiveurl=https://web.archive.org/web/20041111235938/http://www.smbs.buffalo.edu/pth600/IMC-Path/y2case/y2ans10.htm | archivedate=2004-11-11}} 2 : Tuberculosis|Histopathology |
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