| 词条 | HLA-DR10 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 释义 |
HLA-DR10 (DR10) is a HLA-DR serotype that recognizes the DRB1*1001 gene product. Serology
The serological reaction of DR10 is relatively good. Disease associationsBy serotpyeDR10 sertoype or cognate alleles are associated with: Lichen planus[2] By alleleDRB1*1001 is associated with ovarian cancer[3] and invasive squamous cell cervical cancer (SCC)[4]Extended linkageDRB1*1001:DQA1*01:DQB1*05 haplotype: Rheumatoid arthritis[5] The primary involvement appears to be DR10. Genetic Linkage
HLA-DR10 is not genetically linked to DR51, DR52 or DR53, but is linked to HLA-DQ1 and DQ5 serotypes. One haplotype found in caucasians is the HLA-A1-B37-Cw6-DR10-DQ5. References1. ^derived from IMGT/HLA {{DR serotypes}}{{DEFAULTSORT:Hla-Dr10}}2. ^{{cite journal |vauthors=White A, Rostom A | title = HLA antigens in Arabs with lichen planus. | journal = Clin Exp Dermatol | volume = 19 | issue = 3 | pages = 236–7 | year = 1994 | pmid = 8033385 | doi = 10.1111/j.1365-2230.1994.tb01174.x}} 3. ^{{cite journal |vauthors=Kübler K, Arndt P, Wardelmann E, Krebs D, Kuhn W, van der Ven K | title = HLA-class II haplotype associations with ovarian cancer. | journal = Int J Cancer | volume = 119 | issue = 12 | pages = 2980–5 | year = 2006 | pmid = 17016821 | doi = 10.1002/ijc.22266}} 4. ^{{cite journal |vauthors=Madeleine M, Brumback B, Cushing-Haugen K, Schwartz S, Daling J, Smith A, Nelson J, Porter P, Shera K, McDougall J, Galloway D | title = Human leukocyte antigen class II and cervical cancer risk: a population-based study. | journal = J Infect Dis | volume = 186 | issue = 11 | pages = 1565–74 | year = 2002 | pmid = 12447731 | doi = 10.1086/345285}} 5. ^{{cite journal |vauthors=Pascual M, Nieto A, López-Nevot M, Ramal L, Matarán L, Caballero A, Alonso A, Martín J, Zanelli E | title = Rheumatoid arthritis in southern Spain: toward elucidation of a unifying role of the HLA class II region in disease predisposition. | journal = Arthritis Rheum | volume = 44 | issue = 2 | pages = 307–14 | year = 2001 | pmid = 11229460 | doi = 10.1002/1529-0131(200102)44:2<307::AID-ANR47>3.0.CO;2-K}} 1 : HLA-DR haplotypes |
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