James Knox (1914–1983) was the Catholic archbishop of Melbourne, 1967–74.

James or Jim Knox may also refer to:

• James Hall Mason Knox (1824 - 1903), Presbyterian, educator, president of Lafayette College
• James Knox (cyclist) (born 1995), British cyclist
• James Knox (Illinois politician) (1807–1876), U.S. Representative from Illinois
• James Knox (Montana politician) (born 1965), Republican member of the Montana Legislature and politician
• James Meldrum Knox (1878–1918), British Army officer
• James Knox, lead singer of The Waltones
• Jim Knox (1919–1991), New Zealand trade unionist and politician
• Jim Knox (American football), Fox Sports American football commentator, see 2000 Oklahoma Sooners football team
• Jim Knox (ice hockey), Canadian ice hockey player, 1966 Memorial Cup

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