| 词条 | 90Y-DOTA-biotin |
| 释义 |
In pretargeted radioimmunotherapy, two or three medications are applied in succession. At first, an antibody-drug conjugate is administered, which consists of a monoclonal antibody designed to target the tumour, and a chemical marker which in the case of DOTA-biotin therapy is one of the proteins avidin and streptavidin. After a time of typically one or two days to let the antibody accumulate in the tumour, a clearing agent may be given to eliminate residues of antibody that are still circulating in the bloodstream; this is especially done in humans. After a further waiting time, the radiotherapy (90Y-DOTA-biotin) is administered. Due to the high affinity of biotin to avidin and streptavidin, the radiotherapy accumulates where the antibody is, namely in the tumour, where it delivers its radioactivity.[3] {{Clear}}References1. ^1 {{cite journal |author =Pagel JM |author2 =Kenoyer AL |author3 =Bäck T |title=Anti-CD45 pretargeted radioimmunotherapy using bismuth-213: high rates of complete remission and long-term survival in a mouse myeloid leukemia xenograft model |journal=Blood |volume= 118|issue= 3|pages= 703–11|date=May 2011 |pmid=21613259 |doi=10.1182/blood-2011-04-347039 |url=http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=21613259 |pmc=3142907|display-authors=etal}} [1][2][3][4]2. ^1 2 {{cite journal|pmid=10690517|year=2000|last1=Knox|first1=SJ|last2=Goris|first2=ML|last3=Tempero|first3=M|last4=Weiden|first4=PL|last5=Gentner|first5=L|last6=Breitz|first6=H|last7=Adams|first7=GP|last8=Axworthy|first8=D|last9=Gaffigan|first9=S|last10=Bryan|first10=K|last11=Fisher|first11=DR|last12=Colcher|first12=D|last13=Horak|first13=ID|last14=Weiner|first14=LM|title=Phase II trial of yttrium-90-DOTA-biotin pretargeted by NR-LU-10 antibody/streptavidin in patients with metastatic colon cancer|volume=6|issue=2|pages=406–14|journal=Clinical Cancer Research}} 3. ^1 {{Cite journal | last1 = Paganelli | first1 = G. | last2 = Ferrari | first2 = M. | last3 = Ravasi | first3 = L. | last4 = Cremonesi | first4 = M. | last5 = De Cicco | first5 = C. | last6 = Galimberti | first6 = V. | last7 = Sivolapenko | first7 = G. | last8 = Luini | first8 = A. | last9 = De Santis | first9 = R. | last10 = Travaini | first10 = L. L. | last11 = Fiorenza | first11 = M. | last12 = Chinol | first12 = M. | last13 = Papi | first13 = S. | last14 = Zanna | first14 = C. | last15 = Carminati | first15 = P. | last16 = Veronesi | first16 = U. | title = Intraoperative Avidination for Radionuclide Therapy: A Prospective New Development to Accelerate Radiotherapy in Breast Cancer | doi = 10.1158/1078-0432.CCR-07-1058 | journal = Clinical Cancer Research | volume = 13 | issue = 18 | pages = 5646s–5651s | year = 2007 | pmid = 17875802| pmc = }} 4. ^1 {{cite journal|doi=10.1021/ol100774p|title=Synthesis of a DOTA−Biotin Conjugate for Radionuclide Chelation via Cu-Free Click Chemistry|year=2010|last1=Schultz|first1=Michael K.|last2=Parameswarappa|first2=Sharavathi G.|last3=Pigge|first3=F. Christopher|journal=Organic Letters|volume=12|issue=10|pages=2398–401|pmid=20423109}} }}{{antineoplastic-drug-stub}} 1 : Radiopharmaceuticals |
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