| 词条 | Corrin |
| 释义 |
| verifiedrevid = 443543138 | ImageFile=Corrin.svg | ImageSize= | IUPACName= | OtherNames= |Section1={{Chembox Identifiers | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 16736705 | InChIKey = WUPRCGRRQUZFAB-DEGKJRJSBL | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C19H22N4/c1-3-14-10-16-5-7-18(22-16)19-8-6-17(23-19)11-15-4-2-13(21-15)9-12(1)20-14/h9-11,18-19,22H,1-8H2/b12-9-,15-11-,16-10- | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = WUPRCGRRQUZFAB-DEGKJRJSSA-N | CASNo_Ref = {{cascite|correct|??}} | CASNo=262-76-0 | PubChem=6438343 | InChI = 1/C19H22N4/c1-3-14-10-16-5-7-18(22-16)19-8-6-17(23-19)11-15-4-2-13(21-15)9-12(1)20-14/h9-11,18-19,22H,1-8H2/b12-9-,15-11-,16-10- | ChEBI_Ref = {{ebicite|correct|EBI}} | ChEBI = 33221 | SMILES = N=1C=4CCC=1\\C=C2/NC(CC2)C\\5CC/C(C=C3\\CC/C(=N3)/C=4)=N/5 }} |Section2={{Chembox Properties | Formula=C19H22N4 | MolarMass=306.40478 | Appearance= | Density= | MeltingPt= | BoilingPt= | Solubility= |Section3={{Chembox Hazards | MainHazards= | FlashPt= | AutoignitionPt = }}Corrin is a heterocyclic compound. It is the parent macrocycle related to the substituted derivative that is found in vitamin B12. Its name reflects that it is the "core" of vitamin B12 (cobalamins).[1] Coordination chemistry{{main|vitamin B12|l1=Vitamin B12}}Upon deprotonation, the corrinoid ring is capable of binding cobalt. In vitamin B12, the resulting complex also features a benzimidazole-derived ligand, and the sixth site on the octahedron serves as the catalytic center. The corrin ring resembles the porphyrin ring, which occurs in hemoglobin. Both feature four pyrrole-like subunits organized into a ring with a largely conjugated structure of alternating double and single bonds. In contrast to porphyrins, corrins lack one of the carbon groups that link the pyrrole-like units into a fully conjugated structure. With a conjugated system that extends only 3/4 of the way around the ring, and does not include any of the outer edge carbons, corrins have a number of non-conjugated sp3 carbons, making them more flexible than porphyrins and not as flat. A third closely related biological structure, the chlorin ring system found in chlorophyll, is intermediate between porphyrin and corrin, having 20 carbons like the porphyrins and a conjugated structure extending all the way around the central atom, but with only 6 of the 8 edge carbons participating. Corroles (octadehydrocorrins) are fully aromatic derivatives of corrins. References1. ^Nelson, D. L.; Cox, M. M. "Lehninger, Principles of Biochemistry" 3rd Ed. Worth Publishing: New York, 2000. {{ISBN|1-57259-153-6}}. {{Tetrapyrroles}}{{portal bar|Metabolism}} 4 : Biomolecules|Tetrapyrroles|Metabolism|Macrocycles |
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