| 释义 |
- Interactions
- References
- Further reading
{{Infobox_gene}}Importin subunit alpha-1 is a protein that in humans is encoded by the KPNA1 gene.[1]InteractionsKaryopherin alpha 1 has been shown to interact with KPNB1[2][3] and UBR5.[4] References1. ^{{cite journal |vauthors=Cortes P, Ye ZS, Baltimore D | title = RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1 | journal = Proc Natl Acad Sci U S A | volume = 91 | issue = 16 | pages = 7633–7 |date=Sep 1994 | pmid = 8052633 | pmc = 44456 | doi =10.1073/pnas.91.16.7633 | bibcode =1994PNAS...91.7633C }}
2. ^{{cite journal |last=Köhler |first=M |authorlink= |author2=Speck C |author3=Christiansen M |author4=Bischoff F R |author5=Prehn S |author6=Haller H |author7=Görlich D |author8=Hartmann E |date=Nov 1999 |title=Evidence for distinct substrate specificities of importin alpha family members in nuclear protein import |journal=Mol. Cell. Biol. |volume=19 |issue=11 |pages=7782–91 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 10523667 |pmc=84838 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = | doi=10.1128/mcb.19.11.7782}}
3. ^{{cite journal |last=Percipalle |first=P |authorlink= |author2=Clarkson W D |author3=Kent H M |author4=Rhodes D |author5=Stewart M |date=Mar 1997 |title=Molecular interactions between the importin alpha/beta heterodimer and proteins involved in vertebrate nuclear protein import |journal=J. Mol. Biol. |volume=266 |issue=4 |pages=722–32 |publisher= |location = ENGLAND| issn = 0022-2836| pmid = 9102465 |doi = 10.1006/jmbi.1996.0801 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}
4. ^{{cite journal |last=Henderson |first=Michelle J |authorlink= |author2=Russell Amanda J |author3=Hird Samantha |author4=Muñoz Marcia |author5=Clancy Jennifer L |author6=Lehrbach Gillian M |author7=Calanni Sophina T |author8=Jans David A |author9=Sutherland Robert L |author10=Watts Colin K W |date=Jul 2002 |title=EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response |journal=J. Biol. Chem. |volume=277 |issue=29 |pages=26468–78 |publisher= |location = United States| issn = 0021-9258| pmid = 12011095 |doi = 10.1074/jbc.M203527200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Bukrinsky MI, Haffar OK |title=HIV-1 nuclear import: in search of a leader. |journal=Front. Biosci. |volume=2 |issue= |pages= d578–87 |year= 2004 |pmid= 9366553 |doi= 10.2741/A213}}
- {{cite journal |vauthors=Bukrinsky MI, Haffar OK |title=HIV-1 nuclear import: matrix protein is back on center stage, this time together with Vpr. |journal=Mol. Med. |volume=4 |issue= 3 |pages= 138–43 |year= 1998 |pmid= 9562972 | pmc=2230352 |doi= }}
- {{cite journal |vauthors=Kino T, Pavlakis GN |title=Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1. |journal=DNA Cell Biol. |volume=23 |issue= 4 |pages= 193–205 |year= 2004 |pmid= 15142377 |doi= 10.1089/104454904773819789 }}
- {{cite journal |vauthors=Bukrinsky MI, Sharova N, Dempsey MP, etal |title=Active nuclear import of human immunodeficiency virus type 1 preintegration complexes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 14 |pages= 6580–4 |year= 1992 |pmid= 1631159 | pmc=49545 |doi=10.1073/pnas.89.14.6580 |bibcode=1992PNAS...89.6580B }}
- {{cite journal |vauthors=Sharova N, Bukrinskaya A |title=p17 and p17-containing gag precursors of input human immunodeficiency virus are transported into the nuclei of infected cells. |journal=AIDS Res. Hum. Retroviruses |volume=7 |issue= 3 |pages= 303–6 |year= 1991 |pmid= 2064827 |doi=10.1089/aid.1991.7.303 }}
- {{cite journal |vauthors=Di Marzio P, Choe S, Ebright M, etal |title=Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr. |journal=J. Virol. |volume=69 |issue= 12 |pages= 7909–16 |year= 1996 |pmid= 7494303 | pmc=189735 |doi= }}
- {{cite journal |vauthors=Gallay P, Swingler S, Song J, etal |title=HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integrase. |journal=Cell |volume=83 |issue= 4 |pages= 569–76 |year= 1995 |pmid= 7585960 |doi=10.1016/0092-8674(95)90097-7 }}
- {{cite journal |vauthors=Moroianu J, Hijikata M, Blobel G, Radu A |title=Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 14 |pages= 6532–6 |year= 1995 |pmid= 7604027 | pmc=41552 |doi= 10.1073/pnas.92.14.6532|bibcode=1995PNAS...92.6532M }}
- {{cite journal |vauthors=Freed EO, Englund G, Martin MA |title=Role of the basic domain of human immunodeficiency virus type 1 matrix in macrophage infection. |journal=J. Virol. |volume=69 |issue= 6 |pages= 3949–54 |year= 1995 |pmid= 7745752 | pmc=189124 |doi= }}
- {{cite journal |vauthors=Weis K, Mattaj IW, Lamond AI |title=Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences. |journal=Science |volume=268 |issue= 5213 |pages= 1049–53 |year= 1995 |pmid= 7754385 |doi=10.1126/science.7754385 |bibcode=1995Sci...268.1049W }}
- {{cite journal |vauthors=O'Neill RE, Palese P |title=NPI-1, the human homolog of SRP-1, interacts with influenza virus nucleoprotein. |journal=Virology |volume=206 |issue= 1 |pages= 116–25 |year= 1995 |pmid= 7831767 |doi=10.1016/S0042-6822(95)80026-3 }}
- {{cite journal |vauthors=Gallay P, Swingler S, Aiken C, Trono D |title=HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator. |journal=Cell |volume=80 |issue= 3 |pages= 379–88 |year= 1995 |pmid= 7859280 |doi=10.1016/0092-8674(95)90488-3 }}
- {{cite journal |vauthors=Moroianu J, Blobel G, Radu A |title=Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import substrate at nuclear pore complexes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 6 |pages= 2008–11 |year= 1995 |pmid= 7892216 | pmc=42412 |doi=10.1073/pnas.92.6.2008 |bibcode=1995PNAS...92.2008M }}
- {{cite journal |vauthors=von Schwedler U, Kornbluth RS, Trono D |title=The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T lymphocytes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 15 |pages= 6992–6 |year= 1994 |pmid= 8041734 | pmc=44324 |doi=10.1073/pnas.91.15.6992 |bibcode=1994PNAS...91.6992V }}
- {{cite journal |vauthors=Heinzinger NK, Bukinsky MI, Haggerty SA, etal |title=The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 15 |pages= 7311–5 |year= 1994 |pmid= 8041786 | pmc=44389 |doi=10.1073/pnas.91.15.7311 |bibcode=1994PNAS...91.7311H }}
- {{cite journal |vauthors=Bukrinsky MI, Haggerty S, Dempsey MP, etal |title=A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells. |journal=Nature |volume=365 |issue= 6447 |pages= 666–9 |year= 1993 |pmid= 8105392 |doi= 10.1038/365666a0 |bibcode=1993Natur.365..666B }}
- {{cite journal |vauthors=Dubrovsky L, Ulrich P, Nuovo GJ, etal |title=Nuclear localization signal of HIV-1 as a novel target for therapeutic intervention. |journal=Mol. Med. |volume=1 |issue= 2 |pages= 217–30 |year= 1996 |pmid= 8529100 | pmc=2229944 |doi= }}
- {{cite journal |vauthors=Gallay P, Stitt V, Mundy C, etal |title=Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import. |journal=J. Virol. |volume=70 |issue= 2 |pages= 1027–32 |year= 1996 |pmid= 8551560 | pmc=189908 |doi= }}
- {{cite journal |vauthors=Bukrinskaya AG, Ghorpade A, Heinzinger NK, etal |title=Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 1 |pages= 367–71 |year= 1996 |pmid= 8552640 | pmc=40239 |doi=10.1073/pnas.93.1.367 |bibcode=1996PNAS...93..367B }}
{{refend}}{{PDB Gallery|geneid=3836}}{{gene-3-stub}} 1 : Armadillo-repeat-containing proteins |