| 词条 | Mast cell stabilizer |
| 释义 |
Mast cell stabilizers are chromone medications used to prevent or control certain allergic disorders. They block mast cell degranulation, stabilizing the cell and thereby preventing the release of histamine[1] and related mediators. One suspected pharmacodynamic mechanism is the blocking of IgE-regulated calcium channels. Without intracellular calcium, the histamine vesicles cannot fuse to the cell membrane and degranulate. As inhalers they are used to treat asthma, as nasal sprays to treat hay fever (allergic rhinitis) and as eye drops for allergic conjunctivitis.[2] Finally, in oral form, they are used to treat the rare condition of mastocytosis. ExamplesMast cell stabilizer medications include:
References1. ^{{cite web|url=http://www.mayoclinic.com/health/allergy-medications/AA00037 |title=Allergy medications: Know your options |publisher=Mayoclinic.com |date=2017-06-06 |accessdate=2018-05-24}} {{Asthma and copd_rx}}{{Nasal preparations}}{{respiratory-system-drug-stub}}2. ^{{cite journal |authors=Castillo M, Scott NW, Mustafa MZ, Mustafa MS, Azuara-Blanco A |title= Topical antihistamines and mast cell stabilisers for treating seasonal and perennial allergic conjunctivitis |journal=Cochrane Database Syst Rev|volume=6 |pages= CD009566 |date=2015 |pmid= 26028608 |doi= 10.1002/14651858.CD009566.pub2}} 3. ^{{cite journal | last1 = Lui | first1 = ZQ | last2 = Lii | first2 = XX | last3 = Qui | first3 = ZQ | last4 = Yu | first4 = Y | last5 = Li | first5 = MG | title = Vitamin D contributes to mast cell stabilization. | journal = Allergy | volume = 72 | issue = 8 | pages = 1184-1192 | year = 2017 | pmid = 27998003 | doi = 10.1111/all.13110 }} 1 : Mast cell stabilizers |
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