“MYB (gene)”的意思、由来-开放百科全书

Function

Animals

Myb proto-oncogene protein is a member of the MYB (myeloblastosis) family of transcription factors. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression.

Plants

MYB factors represent a family of proteins that include the conserved MYB DNA-binding domain. Plants contain a MYB-protein subfamily that is characterised by the R2R3-type MYB domain.^[3]

In maize, phlobaphenes are synthesized in the flavonoids synthetic pathway^[4] from polymerisation of flavan-4-ols^[5]^[6] which encodes an R2R3 myb-like transcriptional activator^[7] of the A1 gene encoding for the dihydroflavonol 4-reductase (reducing dihydroflavonols into flavan-4-ols)^[8] while another gene (Suppressor of Pericarp Pigmentation 1 or SPP1) acts as a suppressor.^[9] The maize P gene encodes a Myb homolog that recognizes the sequence CCT/AACC, in sharp contrast with the C/TAACGG bound by vertebrate Myb proteins.^[10]

In sorghum, the corresponding yellow seed 1 gene (y1)^[11] also encodes a R2R3 type of Myb domain protein that regulates the expression of chalcone synthase, chalcone isomerase and dihydroflavonol reductase genes required for the biosynthesis of 3-deoxyflavonoids.^[12]

Ruby is a MYB transcriptional activator of genes that produce anthocyanin in citrus fruits. In most citrus varieties Ruby is non-functional, but in blood oranges it upregulates anthocyanin production to produce the characteristic red color of the fruit.^[13]

See also

References

1. ^{{cite journal |vauthors=Chen Y, Xu H, Liu J, Zhang C, Leutz A, Mo X | title = The c-Myb functions as a downstream target of PDGF-mediated survival signal in vascular smooth muscle cells | journal = Biochem Biophys Res Commun | volume = 360 | issue = 2 | pages = 433–6 | date = Jul 2007 | pmid = 17599807 | pmc = | doi = 10.1016/j.bbrc.2007.06.078 }}
2. ^{{cite web | title = Entrez Gene: v-myb myeloblastosis viral oncogene homolog (avian)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4602| accessdate = }}
3. ^{{cite journal |vauthors=Stracke R, Werber M, Weisshaar B | title = The R2R3-MYB gene family in Arabidopsis thaliana | journal = Curr. Opin. Plant Biol. | volume = 4 | issue = 5 | pages = 447–56 | date = October 2001 | pmid = 11597504 | doi = 10.1016/s1369-5266(00)00199-0 }}
4. ^{{cite journal |vauthors=Himi E, Mares DJ, Yanagisawa A, Noda K | title = Effect of grain colour gene (R) on grain dormancy and sensitivity of the embryo to abscisic acid (ABA) in wheat | journal = J. Exp. Bot. | volume = 53 | issue = 374 | pages = 1569–74 | date = July 2002 | pmid = 12096095 | doi = 10.1093/jxb/erf005 }}
5. ^{{cite journal | author = Winkel-Shirley B | title = Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology | journal = Plant Physiol. | volume = 126 | issue = 2 | pages = 485–93 | date = June 2001 | pmid = 11402179 | pmc = 1540115 | doi = 10.1104/pp.126.2.485 }}
6. ^{{cite journal |vauthors=Chopra S, Cocciolone SM, Bushman S, Sangar V, McMullen MD, Peterson T | title = The maize unstable factor for orange1 is a dominant epigenetic modifier of a tissue specifically silent allele of pericarp color1 | journal = Genetics | volume = 163 | issue = 3 | pages = 1135–46 | date = March 2003 | pmid = 12663550 | pmc = 1462483 | doi = }}
7. ^Structural And Transcriptional Analysis Of The Complex P1-wr Cluster In Maize. Wolfgang Goettel, Joachim Messing. Plant & Animal Genomes XVI Conference {{webarchive|url=https://web.archive.org/web/20120218100748/http://www.intl-pag.org/16/abstracts/PAG16_P05d_343.html |date=2012-02-18 }}
8. ^{{cite journal |vauthors=Dong X, Braun EL, Grotewold E | title = Functional conservation of plant secondary metabolic enzymes revealed by complementation of Arabidopsis flavonoid mutants with maize genes | journal = Plant Physiol. | volume = 127 | issue = 1 | pages = 46–57 | date = September 2001 | pmid = 11553733 | pmc = 117961 | doi = 10.1104/pp.127.1.46 | url = http://www.plantphysiol.org/cgi/reprint/127/1/46.pdf }}
9. ^{{cite journal | title = Suppressor of Pericarp Pigmentation 1 (SPP1), a novel gene involved in phlobaphene accumulation in maize (Zea mays L.) pericarps. |vauthors=Lee EA, Harper V | journal = Maydica | year = 2002 | volume = 47 | issue = 1 | pages = 51–58 }} {{INIST|13772300}}
10. ^The myb-homologous P gene controls phlobaphene pigmentation in maize floral organs by directly activating a flavonoid biosynthetic gene subset. Erich Grotewold, Bruce J. Drummond, Ben Bowen and Thomas Peterson, Cell, 11 February 199, Volume 76, Issue 3, pages 543-554, {{doi|10.1016/0092-8674(94)90117-1}} {{PMID|8313474}}
11. ^{{cite journal | title = Characterization of a deletion allele of a sorghum Myb gene yellow seedl showing loss of 3-deoxyflavonoids |vauthors=Boddu J, Svabek C, Ibraheem F, Jones AD, Chopra S | journal = Plant Science | year = 2005 | volume = 169 | issue = 3 | pages = 542–552 | doi=10.1016/j.plantsci.2005.05.007}} {{INIST|16983977}}
12. ^{{cite journal |vauthors=Boddu J, Jiang C, Sangar V, Olson T, Peterson T, Chopra S | title = Comparative structural and functional characterization of sorghum and maize duplications containing orthologous myb transcription regulators of 3-deoxyflavonoid biosynthesis | journal = Plant Mol. Biol. | volume = 60 | issue = 2 | pages = 185–99 | date = January 2006 | pmid = 16429259 | doi = 10.1007/s11103-005-3568-1 }}
13. ^{{cite journal |vauthors=Butelli E, Licciardello C, Zhang Y, Liu J, Mackay S, Bailey P, Reforgiato-Recupero G, Martin C | title = Retrotransposons control fruit-specific, cold-dependent accumulation of anthocyanins in blood oranges | journal = Plant Cell | volume = 24 | issue = 3 | pages = 1242–55 | year = 2012 | pmid = 22427337 | pmc = 3336134 | doi = 10.1105/tpc.111.095232 }}

Function

Animals

Plants

See also

References

Further reading

External links