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词条 Myogenic regulatory factors
释义

  1. References

  2. External links

Myogenic regulatory factors (MRF) are basic helix-loop-helix (bHLH) transcription factors that regulate myogenesis: MyoD, Myf5, myogenin, and MRF4.[1]

These proteins contain a conserved basic DNA binding domain that binds the E box DNA motif.[2] They dimerize with other HLH containing proteins through an HLH-HLH interaction.[3]

References

1. ^{{cite journal |vauthors=Perry R, Rudnick M |title=Molecular mechanisms regulating myogenic determination and differentiation |journal=Front Biosci |volume=5 |issue= |pages=D750–67 |year= 2000|pmid=10966875 |doi=10.2741/Perry}}
2. ^{{cite journal |vauthors=Weintraub H, Davis R, Tapscott S, Thayer M, Krause M, Benezra R, Blackwell T, Turner D, Rupp R, Hollenberg S |title=The myoD gene family: nodal point during specification of the muscle cell lineage |journal=Science |volume=251 |issue=4995 |pages=761–6 |year=1991 |pmid=1846704 |doi=10.1126/science.1846704}}
3. ^{{cite journal |vauthors=Barndt R, Zhuang Y |title=Controlling lymphopoiesis with a combinatorial E-protein code |journal=Cold Spring Harb Symp Quant Biol |volume=64 |issue= |pages=45–50 |year= 1999|pmid=11232321 |doi=10.1101/sqb.1999.64.45}}

External links

  • {{MeshName|Myogenic+Regulatory+Factors}}
{{Transcription factors|g1}}

2 : Transcription factors|DNA-binding proteins

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