“Orciprenaline”的意思、由来-开放百科全书

词条

Orciprenaline

释义

Possible side effects
Brand names
References

{{Drugbox
| Verifiedfields = changed
| verifiedrevid = 408782146
| IUPAC_name = (RS)-5-[1-hydroxy-2-(isopropylamino)ethyl]benzene-1,3-diol
| image = Orciprenaline.svg
| width =
| chirality = Racemic mixture
| USAN = Metaproterenol
| tradename =
| Drugs.com = [https://www.drugs.com/monograph/metaproterenol-sulfate.html monograph]
| MedlinePlus = a682084
| pregnancy_AU = A
| pregnancy_US = C
| legal_US = Rx-only
| routes_of_administration = Inhalation (MDI) and tablets
| bioavailability = 3% if inhaled, 40% if taken orally
| protein_bound =
| metabolism = Gastrointestinal and hepatic
| elimination_half-life = 6 hours
| IUPHAR_ligand = 7250
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 586-06-1
| ATC_prefix = R03
| ATC_suffix = AB03
| ATC_supplemental = {{ATC|R03|CB03}}
{{ATC|R03|CB53}}
| PubChem = 4086
| DrugBank_Ref = {{drugbankcite|changed|drugbank}}
| DrugBank = DB00816
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 3944
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 53QOG569E0
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D08300
| ChEBI_Ref = {{ebicite|changed|EBI}}
| ChEBI = 82719
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 776
| C=11 | H=17 | N=1 | O=3
| molecular_weight = 211.258 g/mol
| smiles = Oc1cc(cc(O)c1)C(O)CNC(C)C
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-9(13)5-10(14)4-8/h3-5,7,11-15H,6H2,1-2H3
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = LMOINURANNBYCM-UHFFFAOYSA-N
| solubility = 9.7
}}

Orciprenaline, also known as metaproterenol, is a bronchodilator used in the treatment of asthma.^[1]^[2] Orciprenaline is a moderately selective β₂ adrenergic receptor agonist that stimulates receptors of the smooth muscle in the lungs, uterus, and vasculature supplying skeletal muscle, with minimal or no effect on α adrenergic receptors. The pharmacologic effects of β adrenergic agonist drugs, such as orciprenaline, are at least in part attributable to stimulation through β adrenergic receptors of intracellular adenylyl cyclase, the enzyme which catalyzes the conversion of ATP to cAMP. Increased cAMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from many cells, especially from mast cells.

Possible side effects

tremor
nervousness
dizziness
weakness
headache
nausea
tachycardia

Rare side effects that could be life-threatening

increased difficulty breathing
rapid or increased heart rate
irregular heartbeat
chest pain or discomfort

Brand names

Alupent
Metaprel
Orcibest

References

1. ^{{cite journal |title = DrugBank 3.0: a comprehensive resource for omics research on drugs |vauthors=Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS |journal = Nucleic Acids Res. |year = 2011 |volume = 39 |issue = Database issue |pages = D1035-41 | pmid =21059682 |doi=10.1093/nar/gkq1126 |pmc=3013709}}
2. ^{{cite journal |title = DrugBank: a knowledgebase for drugs, drug actions and drug targets |vauthors=Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M |journal = Nucleic Acids Res |year = 2008 |volume = 36 |issue = Database issue |pages = D901-6 |pmid = 18048412 |doi=10.1093/nar/gkm958 |pmc=2238889}}

3 : Chemical substances for emergency medicine|Phenethylamines|Bronchodilators

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