“Ribosyldihydronicotinamide dehydrogenase (quinone)”的意思、由来-开放百科全书

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Ribosyldihydronicotinamide dehydrogenase (quinone)

释义

References

{{enzyme
| Name = dihydronicotinamide riboside quinone reductase
| EC_number = 1.10.99.2
| CAS_number =
| IUBMB_EC_number = 1/10/99/2
| GO_code = 0001512
| image = 5lby.jpg
| width = 270
| caption = Ribosyldihydronicotinamide dehydrogenase dimer, Human
}}

In enzymology, a ribosyldihydronicotinamide dehydrogenase (quinone) ({{EC number|1.10.99.2}}) is an enzyme that catalyzes the chemical reaction

1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone

Thus, the two substrates of this enzyme are 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide and quinone, whereas its two products are 1-(beta-D-ribofuranosyl)nicotinamide and hydroquinone.

This enzyme belongs to the family of oxidoreductases, specifically those acting on diphenols and related substances as donor with other acceptors. The systematic name of this enzyme class is 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide:quinone oxidoreductase. Other names in common use include NRH:quinone oxidoreductase 2, NQO2, NQO2, NAD(P)H:quinone oxidoreductase-2 (misleading), QR2, quinone reductase 2, N-ribosyldihydronicotinamide dehydrogenase (quinone), and NAD(P)H:quinone oxidoreductase2 (misleading).

References

{{cite journal | vauthors = LIAO S, DULANEY JT, WILLIAMS-ASHMAN HG | date = 1962 | title = Purification and properties of a flavoprotein catalyzing the oxidation of reduced ribosyl nicotinamide | journal = J. Biol. Chem. | volume = 237 | pages = 2981–7 | pmid = 14465018 }}
{{cite journal | vauthors = Zhao Q, Yang XL, Holtzclaw WD, Talalay P | date = 1997 | title = Unexpected genetic and structural relationships of a long-forgotten flavoenzyme to NAD(P)H:quinone reductase (DT-diaphorase) | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | pages = 1669–74 | pmid = 9050836 | doi = 10.1073/pnas.94.5.1669 | issue = 5 | pmc = 19974 }}
{{cite journal | author = S | date = 1997 | title = Catalytic properties of NAD(P)H:quinone oxidoreductase-2 (NQO2), a dihydronicotinamide riboside dependent oxidoreductase | journal = Arch. Biochem. Biophys. | volume = 347 | pages = 221–8 | pmid = 9367528 | doi = 10.1006/abbi.1997.0344 | last2 = Knox | first2 = R | last3 = Sun | first3 = XZ | last4 = Joseph | first4 = P | last5 = Jaiswal | first5 = AK | last6 = Zhang | first6 = D | last7 = Deng | first7 = PS | last8 = Chen | first8 = S | issue = 2 }}
{{cite journal | author = Jaiswal AK | date = 1994 | title = Human NAD(P)H:quinone oxidoreductase2. Gene structure, activity, and tissue-specific expression | journal = J. Biol. Chem. | volume = 269 | pages = 14502–8 | pmid = 8182056 | issue = 20 }}

{{Diphenol family oxidoreductases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{1.10-enzyme-stub}}

2 : EC 1.10.99|Enzymes of unknown structure

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