| 词条 | Ronald Duman |
| 释义 |
EducationDuman received his Ph.D. in 1985 from The University of Texas Health Science Center at Houston. CareerRon Duman's research centers around the biological mechanisms behind antidepressants. In his landmark 1995 paper, he discovered that antidepressants increase the gene expression of Brain-Derived Neurotrophic Factor, or (BDNF)[2] in the hippocampus. In a later paper he discovered that the downstream effect of BDNF is to increase neurogenesis or the formation of new neurons in the dentate gyrus of the hippocampus.[3] The results of this work led him to formulate the hypothesis that depression is caused by a decrease in hippocampal neurogenesis caused by elevated cortisol levels. Notes1. ^Duman's Yale Faculty Website {{webarchive |url=https://www.webcitation.org/5v40CvNzH?url=http://www.med.yale.edu/psych/faculty/duman.html |date=18 December 2010 }} {{DEFAULTSORT:Duman, Ronald}}{{US-med-bio-stub}}2. ^[https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=7472505&query_hl=2&itool=pubmed_DocSum First paper demonstrating the link between antidepressants and BDNF levels] {{webarchive|url=https://www.webcitation.org/5v40DWlZM?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=7472505&query_hl=2&itool=pubmed_DocSum |date=18 December 2010 }} 3. ^[https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=11124987&query_hl=2&itool=pubmed_DocSum Abstract of paper demonstrating that antidepressants increase neurogenesis] {{webarchive|url=https://www.webcitation.org/5v40ELbcd?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=11124987&query_hl=2&itool=pubmed_DocSum |date=18 December 2010 }} 3 : Year of birth missing (living people)|Living people|Yale School of Medicine faculty |
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