Space Dementia may refer to:

• "Space Dementia" (song), by Muse
• A fictional mental disorder, mentioned in several works:
  • "Space Madness", a season 1 episode of the animated series The Ren and Stimpy Show
  • Fragile Allegiance, a 1996 PC game
  • "Joyride", a 1999 episode of the TV series The Outer Limits
  • "The Train Job", an episode of the TV series Firefly
  • The feature film Armageddon

• Business simulation
• Business simulation game
• Business Simulations
• Business software alliance
• Business Software Association of Australia
• Business Spur
• Business Spur 495 (Massachusetts)
• Business Spur Interstate 35
• Business Standard
• Business State Highway 6-N (Texas)
• Business State Highway 6-R (Texas)
• Business State Highway 6-S (Texas)
• Business State Highway 6 (Texas)
• Business Still Sucks, Part 2
• Business Strategy
• Business student
• Business students
• Business studies
• Business success
• Business Sucks, Part 1
• Business support system
• Business system
• Business System 12
• Business systems
• Business Systems Analysis