“Stearoyl-CoA 9-desaturase”的意思、由来-开放百科全书

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Stearoyl-CoA 9-desaturase

释义

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{{enzyme
| Name = stearoyl-CoA 9-desaturase
| EC_number = 1.14.19.1
| CAS_number = 9014-34-0
| IUBMB_EC_number = 1/14/19/1
| GO_code = 0004768
| image =
| width =
| caption =
}}

In enzymology, a stearoyl-CoA 9-desaturase ({{EC number|1.14.19.1}}) is an enzyme used to produce the monounsaturated fatty acid oleic acid from the saturated fatty acid stearic acid. It catalyzes the chemical reaction

stearoyl-CoA + 2 ferrocytochrome b₅ + O₂ + 2 H⁺ oleoyl-CoA + 2 ferricytochrome b₅ + 2 H₂O

The 4 substrates of this enzyme are stearoyl-CoA, ferrocytochrome b5, O₂, and H⁺, whereas its 3 products are oleoyl-CoA, ferricytochrome b5, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O₂ as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O₂ with oxidation of a pair of donors resulting in the reduction of O to two molecules of water. The systematic name of this enzyme class is stearoyl-CoA,ferrocytochrome-b5:oxygen oxidoreductase (9,10-dehydrogenating). Other names in common use include Delta9-desaturase, acyl-CoA desaturase, fatty acid desaturase, and stearoyl-CoA, hydrogen-donor:oxygen oxidoreductase. This enzyme participates in polyunsaturated fatty acid biosynthesis and ppar signaling pathway. It employs one cofactor, iron.

References

{{cite journal | vauthors = FULCO AJ, BLOCH K | date = 1964 | title = COFACTOR REQUIREMENTS FOR THE FORMATION OF DELTA-9-UNSATURATED FATTY ACIDS IN MYCOBACTERIUM PHLEI | journal = J. Biol. Chem. | volume = 239 | pages = 993–7 | pmid = 14167617 }}
{{cite journal | vauthors = Oshino N, Imai Y, Sato R | date = 1966 | title = Electron-transfer mechanism associated with fatty acid desaturation catalyzed by liver microsomes | journal = Biochim. Biophys. Acta | volume = 128 | pages = 13–27 | pmid = 4382040 | issue = 1 | doi=10.1016/0926-6593(66)90137-8}}
{{cite journal | vauthors = Oshino N, Imai Y, Sato R | location = Tokyo | title = A function of cytochrome b5 in fatty acid desaturation by rat liver microsomes | journal = J. Biochem. | volume = 69| pages = 155–67 | pmid = 5543646 | issue = 1 | date=January 1971}}
{{cite journal | vauthors = Strittmatter P, Spatz L, Corcoran D, Rogers MJ, Setlow B, Redline R | date = 1974 | title = Purification and properties of rat liver microsomal stearyl coenzyme A desaturase | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 71 | pages = 4565–9 | pmid = 4373719 | doi = 10.1073/pnas.71.11.4565 | issue = 11 | pmc = 433928 }}

3 : EC 1.14.19|Iron enzymes|Enzymes of unknown structure

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