“Thiamine oxidase”的意思、由来-开放百科全书

词条

Thiamine oxidase

释义

References

{{enzyme
| Name = thiamin oxidase
| EC_number = 1.1.3.23
| CAS_number = 96779-44-1
| IUBMB_EC_number = 1/1/3/23
| GO_code = 0050423
| image =
| width =
| caption =
}}

In enzymology, a thiamine oxidase ({{EC number|1.1.3.23}}) is an enzyme that catalyzes the chemical reaction

thiamine + 2 O₂ + H₂O thiamine acetic acid + 2 H₂O₂

The 3 substrates of this enzyme are thiamine, O₂, and H₂O, whereas its two products are thiamine acetic acid and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with oxygen as acceptor. The systematic name of this enzyme class is thiamine:oxygen 5-oxidoreductase. Other names in common use include thiamin dehydrogenase, thiamine dehydrogenase, and thiamin:oxygen 5-oxidoreductase. This enzyme participates in thiamine metabolism. It employs one cofactor, FAD.

References

{{cite journal | vauthors = Edmondson DE, Kenney WC, Singer TP | date = 1976 | title = Structural elucidation and properties of 8alpha-(N1-histidyl)riboflavin: the flavin component of thiamine dehydrogenase and beta-cyclopiazonate oxidocyclase | journal = Biochemistry | volume = 15 | pages = 2937–45 | pmid = 8076 | doi = 10.1021/bi00659a001 | issue = 14 }}
{{cite journal | vauthors = Gomez-Moreno C, Edmondson DE | date = 1985 | title = Evidence for an aldehyde intermediate in the catalytic mechanism of thiamine oxidase | journal = Arch. Biochem. Biophys. | volume = 239 | pages = 46–52 | pmid = 2988447 | doi = 10.1016/0003-9861(85)90810-0 | issue = 1 }}
{{cite journal | author = Neal RA | date = 1970 | title = Bacterial metabolism of thiamine. 3. Metabolism of thiamine to 3-(2'-methyl-4'-amino-5'-pyrimidylmethyl)-4-methyl-thiazole-5-acetic acid (thiamine acetic acid) by a flavoprotein isolated from a soil microorganism | journal = J. Biol. Chem. | volume = 245 | pages = 2599–604 | pmid = 4987737 | issue = 10 }}

3 : EC 1.1.3|Flavin enzymes|Enzymes of unknown structure

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