| 词条 | Tonofibril |
| 释义 |
CompositionTonofilaments are keratin intermediate filaments that makes up tonofibrils in the epithelial tissue. In epithelial cells, tonofilaments loop through desmosomes. Electron microscopy has advanced now to illustrate the Tonofilaments more clearly[2]. The protein filaggrin is believed to have an important role in holding them together as tonofibrils. This protein is known to interact with intermediate filaments, specifically keratins. It is synthesized as a giant Precursor protein, profilaggrin (>400 kDA in humans). When the filaggrin binds to keratin intermediate filaments, it causes aggregation in macrofibrils.[4] References1. ^{{Cite web|title = Epidermis - Derm101|url = http://www.derm101.com/inflammatory/embryologic-histologic-and-anatomic-aspects/epidermis/|website = www.derm101.com|accessdate = 2015-11-23}} 2. ^1 {{DorlandsDict|eight/000109361|tonofibril}} 3. ^{{Cite journal|last=Charles|first=Arwyn|last2=Smiddy|first2=F. G.|date=1957-09-01|title=The Tonofibrils of the Human Epidermis1|url=http://www.nature.com/jid/journal/v29/n5/full/jid1957108a.html#tlnote1|journal=Journal of Investigative Dermatology|volume=29|issue=5|pages=327–338|doi=10.1038/jid.1957.108|issn=0022-202X}} 4. ^1 {{Cite journal|title = Filaggrin in the frontline: role in skin barrier function and disease|url = http://jcs.biologists.org/content/122/9/1285|journal = J Cell Sci|date = 2009-05-01|issn = 0021-9533|pmc = 2721001|pmid = 19386895|pages = 1285–1294|volume = 122|issue = 9|doi = 10.1242/jcs.033969|first = Aileen|last = Sandilands|first2 = Calum|last2 = Sutherland|first3 = Alan D.|last3 = Irvine|first4 = W. H. Irwin|last4 = McLean}} External links
2 : Keratins|Cytoskeleton |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。