| 词条 | Wood–Ljungdahl pathway |
| 释义 |
The Wood–Ljungdahl pathway is a set of biochemical reactions used by some bacteria and archaea called acetogens. It is also known as the reductive acetyl-coenzyme A (Acetyl-CoA) pathway.[1] This pathway enables these organisms to use hydrogen as an electron donor, and carbon dioxide as an electron acceptor and as a building block for biosynthesis. In this pathway carbon dioxide is reduced to carbon monoxide and formic acid or directly into a formyl group, the formyl group is reduced to a methyl group and then combined with the carbon monoxide and Coenzyme A to produce acetyl-CoA. Two specific enzymes participate on the carbon monoxide side of the pathway: CO Dehydrogenase and acetyl-CoA synthase. The former catalyzes the reduction of the CO2 and the latter combines the resulting CO with a methyl group to give acetyl-CoA.[1][2] The pathway occurs in bacteria and archaea, e.g. methanogens[3] and in acetate-producing bacteria such as Clostridium. Unlike the Reverse Krebs cycle and the Calvin cycle, this process is not cyclic. A recent study of the genomes of a set of bacteria and archaea suggests that the last universal common ancestor (LUCA) of all cells was using the Wood–Ljungdahl pathway in a hydrothermal setting.[4] Phylometabolic reconstructions[5] as well as chemical experiments suggest the pathway may have prebiotic origins.[6] See also
References1. ^1 {{cite journal | author = Ragsdale Stephen W | year = 2006 | title = Metals and Their Scaffolds To Promote Difficult Enzymatic Reactions | url = | journal = Chem. Rev. | volume = 106 | issue = 8| pages = 3317–3337 | doi = 10.1021/cr0503153 | pmid=16895330}} 2. ^Paul A. Lindahl "Nickel-Carbon Bonds in Acetyl-Coenzyme A Synthases/Carbon Monoxide Dehydrogenases" Met. Ions Life Sci. 2009, volume 6, pp. 133–150. {{DOI|10.1039/9781847559159-00133}} 3. ^{{Cite journal | last1 = Matschiavelli | first1 = N. | last2 = Oelgeschlager | first2 = E. | last3 = Cocchiararo | first3 = B. | last4 = Finke | first4 = J. | last5 = Rother | first5 = M. | title = Function and regulation of isoforms of carbon monoxide dehydrogenase/acetyl-CoA synthase in Methanosarcina acetivorans | doi = 10.1128/JB.00881-12 | journal = Journal of Bacteriology | year = 2012 | pmid = 22865842 | pmc = 3457241| volume=194 | issue=19 | pages=5377–87}} 4. ^{{cite journal | title = The physiology and habitat of the last universal common ancestor | journal = Nature Microbiology | doi = 10.1038/nmicrobiol.2016.116 | author = M. C. Weiss|display-authors=etal | year = 2016 | volume = 1 | issue = 16116 | pmid=27562259}} 5. ^{{Cite journal|last=Braakman|first=Rogier|last2=Smith|first2=Eric|date=2012-04-19|title=The Emergence and Early Evolution of Biological Carbon-Fixation |journal=PLOS Computational Biology|language=en|volume=8|issue=4|pages=e1002455|doi=10.1371/journal.pcbi.1002455|issn=1553-7358}} 6. ^{{Cite journal|last=Varma|first=Sreejith J.|last2=Muchowska|first2=Kamila B.|last3=Chatelain|first3=Paul|last4=Moran|first4=Joseph|date=2018-04-23|title=Native iron reduces CO2 to intermediates and end-products of the acetyl-CoA pathway|url=https://www.nature.com/articles/s41559-018-0542-2|journal=Nature Ecology & Evolution|volume=2|issue=6|pages=1019–1024|language=En|doi=10.1038/s41559-018-0542-2|issn=2397-334X}} Other reading
1 : Metabolic pathways |
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