WXXI may refer to:

• WXXI (AM), a radio station (1370 AM) licensed to Rochester, New York, United States
• WXXI-FM, a radio station (91.5 FM) licensed to Rochester, New York, United States
• WXXI-TV, a television station (channel 21) licensed to Rochester, New York, United States
• WXXI Public Broadcasting Council, organization that owns the above-listed stations

• Trud (Russian newspaper)
• Trudy (Disney)
• Trudy Huskamp Peterson
• Trudy LeCaine
• Trudy Marshall
• Trudy Monk
• Trudy Pitts
• True
• True air speed
• True airspeed
• True (album)
• True alphabet
• True and Living Church of Jesus Christ of Saints of the Last Days
• True Anomaly
• True anomaly
• True at First Light
• True Audio Codec
• Trueba, Antonio de
• True basic
• True BASIC
• TrueBASIC
• True BASIC programming language
• True Believer
• True believer
• True believers