“4-Bromoaniline”的意思、由来-开放百科全书

词条

4-Bromoaniline

释义

Synthesis
Applications
References

{{Chembox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 477221172
| Reference = ^[1]
| ImageFileL1 = 4-Bromoaniline.svg
| ImageSizeL1 = 80px
| ImageFileR1 = 4-bromoaniline-from-xtal-2003-3D-balls.png
| ImageSizeR1 = 120px
| PIN = 4-Bromoaniline
| OtherNames = {{unbulleted list|1=(4-Bromophenyl)amine|2=p-Bromoaniline|3=4-Bromobenzenamine|4=p-Bromophenylamine}}
|Section1={{Chembox Identifiers
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 7519
| InChI = 1/C6H6BrN/c7-5-1-3-6(8)4-2-5/h1-4H,8H2
| InChIKey = WDFQBORIUYODSI-UHFFFAOYAG
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C6H6BrN/c7-5-1-3-6(8)4-2-5/h1-4H,8H2
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = WDFQBORIUYODSI-UHFFFAOYSA-N
| CASNo_Ref = {{cascite|correct|CAS}}
| CASNo = 106-40-1
| UNII_Ref = {{fdacite|changed|FDA}}
| UNII = 0RR61TC330
| EINECS = 203-393-9
| PubChem = 7807
| RTECS = BW9280000
| UNNumber = 2811
| ChEMBL = 57376
| SMILES = Brc1ccc(N)cc1
}}
|Section2={{Chembox Properties
| Formula = C₆H₆BrN
| MolarMass = 172.02 g mol⁻¹
| Appearance =
| Density = 1.5 g/cm³
| MeltingPtC = 60 to 64
| MeltingPt_notes =
| BoilingPt =
| Solubility = <0.1 g/100 mL at 23 °C
| MagSus = -84.06·10⁻⁶ cm³/mol}}
|Section3={{Chembox Hazards
| ExternalSDS = External MSDS
| GHSPictograms = {{GHS06}}{{GHS07}}{{GHS08}}
| GHSSignalWord = Danger
| HPhrases = {{H-phrases|302|311|315|319|332|335|373}}
| PPhrases = {{P-phrases|260|261|264|270|271|280|301+312|302+352|304+312|304+340|305+351+338|312|314|321|322|330|332+313|337+313|361|362|363|403+233|405|501}}
| MainHazards =
| FlashPt =
| AutoignitionPt = }}
}}4-Bromoaniline is a compound where an aniline molecule is substituted with a bromine atom on the para position. Commercially available, this compound may be used as a building block, e.g. in the preparation of p-bromobiphenyl via the Gomberg-Bachmann reaction.^[2]

Synthesis

4-bromoaniline can be made by reacting aniline with bromine with a protection with acetyl chloride.

Applications

In the synthesis of Bromamid.^&91;3&93;
In the synthesis of Dibromsalan (Disanyl).

References

1. ^4-Bromoaniline, Chemblink.com
2. ^{{OrgSynth | prep = cv1p0113 | collvol = 1 | collvolpages = 113 | author = M. Gomberg and W. E. Bachmann | year = 1941 | title = p-Bromobiphenyl}}
3. ^{{cite journal | pmid = 5863464 | volume=13 | title=Studies on analgesics of aniline series. I. Preparation and properties of beta-alaninamide series | journal=Chem Pharm Bull | pages=198–204 | last1 = Takamura | first1 = K | last2 = Shioya | first2 = A | last3 = Minamoto | first3 = K | last4 = Asada | first4 = N | last5 = Takaku | first5 = S | last6 = Yoshimitsu | first6 = A | last7 = Nitta | first7 = Y}}

2 : Anilines|Bromoarenes

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