“Acetylesterase”的意思、由来-开放百科全书

词条

Acetylesterase

释义

Structural studies
References

{{enzyme
| Name = acetylesterase
| EC_number = 3.1.1.6
| CAS_number = 9000-82-2
| IUBMB_EC_number = 3/1/1/6
| GO_code = 0008126
| image =
| width =
| caption =
}}

In enzymology, an acetylesterase ({{EC number|3.1.1.6}}) is an enzyme that catalyzes the chemical reaction

an acetic ester + H₂O an alcohol + acetate

Thus, the two substrates of this enzyme are acetic ester and H₂O, whereas its two products are alcohol and acetate.

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is acetic-ester acetylhydrolase. Other names in common use include C-esterase (in animal tissues), acetic ester hydrolase, chloroesterase, p-nitrophenyl acetate esterase, and Citrus acetylesterase.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1BS9}}, {{PDB link|1G66}}, and {{PDB link|2AXE}}.

References

{{cite journal | vauthors = Aldridge WN | title = Serum esterases. I. Two types of esterase (A and B) hydrolysing p-nitrophenyl acetate, propionate and butyrate, and a method for their determination | journal = The Biochemical Journal | volume = 53 | issue = 1 | pages = 110–7 | date = January 1953 | pmid = 13032041 | pmc = 1198110 | doi = 10.1042/bj0530110 }}
{{cite journal | vauthors = Bergmann F, Rimon S | title = Fractionation of C-esterase from the hog's kidney extract | journal = The Biochemical Journal | volume = 77 | issue = 2 | pages = 209–14 | date = November 1960 | pmid = 16748846 | pmc = 1204974 | doi = 10.1042/bj0770209 | url = http://www.biochemj.org/bj/077/0209/0770209.pdf | format = PDF }}
{{cite journal | vauthors = Jansen EF, Nutting MD, Balls AK | title = The reversible inhibition of acetylesterase by diisopropyl fluorophosphate and tetraethyl pyrophosphate | journal = The Journal of Biological Chemistry | volume = 175 | issue = 2 | pages = 975–87 | date = September 1948 | pmid = 18880795 | url = http://www.jbc.org/content/175/2/975.full.pdf | format = PDF }}

2 : EC 3.1.1|Enzymes of known structure

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