| 释义 |
- References
- Further reading
- External links
{{Infobox_gene}}Disintegrin and metalloproteinase domain-containing protein 18 is an enzyme that in humans is encoded by the ADAM18 gene.[1][2]This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a sperm surface protein.[2] References1. ^{{cite journal | vauthors = Frayne J, Hurd EA, Hall L | title = Human tMDC III: a sperm protein with a potential role in oocyte recognition | journal = Mol Hum Reprod | volume = 8 | issue = 9 | pages = 817–22 |date=Aug 2002| pmid = 12200459 | pmc = | doi =10.1093/molehr/8.9.817 }}
2. ^1 {{cite web | title = Entrez Gene: ADAM18 ADAM metallopeptidase domain 18| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8749| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Clark HF, Gurney AL, Abaya E |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 |display-authors=etal}}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
- {{cite journal | vauthors=Zhu GZ, Lin Y, Myles DG, Primakoff P |title=Identification of four novel ADAMs with potential roles in spermatogenesis and fertilization. |journal=Gene |volume=234 |issue= 2 |pages= 227–37 |year= 1999 |pmid= 10395895 |doi=10.1016/S0378-1119(99)00208-5 }}
- {{cite journal | vauthors=Frayne J, Jury JA, Barker HL |title=Macaque MDC family of proteins: sequence analysis, tissue distribution and processing in the male reproductive tract. |journal=Mol. Hum. Reprod. |volume=4 |issue= 5 |pages= 429–37 |year= 1998 |pmid= 9665629 |doi=10.1093/molehr/4.5.429 |display-authors=etal}}
- {{cite journal | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
- {{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
{{refend}}External links- The MEROPS online database for peptidases and their inhibitors: M12.957
- {{UCSC gene info|ADAM18}}
{{Metalloendopeptidases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{DEFAULTSORT:Adam18}}{{gene-8-stub}} 3 : Peptidase|Human proteins|EC 3.4.24 |