“BOP1”的意思、由来-开放百科全书

Function

It is a WD40 repeat-containing nucleolar protein involved in rRNA processing, thereby controlling the cell cycle.^[3] It is required for the maturation of the 25S and 5.8S ribosomal RNAs. It may serve as an essential factor in ribosome formation that coordinates processing of the spacer regions in pre-rRNA. The Pes1-Bop1 complex has several components: BOP1, GRWD1, PES1, ORC6L, and RPL3 and is involved in ribosome biogenesis and altered chromosome segregation. The overexpression of BOP1 increases the percentage of multipolar spindles in human cells. Deregulation of the BOP1 pathway may contribute to colorectal tumourigenesis in humans.^[4] Elevated levels of Bop1 induces Bop1/WDR12 and Bop1/Pes1 subcomplexes and the assembly and integrity of the PeBoW complex is highly sensitive to changes in Bop1 protein levels.^[5]

Nop7p-Erb1p-Ytm1p, found in yeast, is potentially the homologous complex of Pes1-Bop1-WDR12 as it is involved in the control of ribosome biogenesis and S phase entry. The integrity of the PeBoW complex is required for ribosome biogenesis and cell proliferation in mammalian cells.^[6] In Giardia, the species specific cytoskeleton protein, beta-giardin, interacts with Bop1.^[3]

Structure

References

1. ^{{cite journal | vauthors = Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N | title = Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1 | journal = DNA Res | volume = 2 | issue = 4 | pages = 167–74, 199–210 | date = Mar 1996 | pmid = 8590280 | pmc = | doi = 10.1093/dnares/2.4.167 }}
2. ^{{cite web | title = Entrez Gene: BOP1 block of proliferation 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23246| accessdate = }}
3. ^¹{{cite journal | vauthors = Kim J, Goo SY, Chung HJ, Yang HW, Yong TS, Lee KH, Park SJ | title = Interaction of beta-giardin with the Bop1 protein in Giardia lamblia | journal = Parasitol. Res. | volume = 98 | issue = 2 | pages = 138–44 | date = January 2006 | pmid = 16362343 | doi = 10.1007/s00436-005-0040-8 | url = }}
4. ^{{cite journal | vauthors = Killian A, Sarafan-Vasseur N, Sesboüé R, Le Pessot F, Blanchard F, Lamy A, Laurent M, Flaman JM, Frébourg T | title = Contribution of the BOP1 gene, located on 8q24, to colorectal tumorigenesis | journal = Genes Chromosomes Cancer | volume = 45 | issue = 9 | pages = 874–81 | date = September 2006 | pmid = 16804918 | doi = 10.1002/gcc.20351 | url = }}
5. ^{{cite journal | vauthors = Rohrmoser M, Hölzel M, Grimm T, Malamoussi A, Harasim T, Orban M, Pfisterer I, Gruber-Eber A, Kremmer E, Eick D | title = Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit | journal = Mol. Cell. Biol. | volume = 27 | issue = 10 | pages = 3682–94 | date = May 2007 | pmid = 17353269 | pmc = 1899993 | doi = 10.1128/MCB.00172-07 | url = }}
6. ^{{cite journal | vauthors = Hölzel M, Rohrmoser M, Schlee M, Grimm T, Harasim T, Malamoussi A, Gruber-Eber A, Kremmer E, Hiddemann W, Bornkamm GW, Eick D | title = Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation | journal = J. Cell Biol. | volume = 170 | issue = 3 | pages = 367–78 | date = August 2005 | pmid = 16043514 | pmc = 2171466 | doi = 10.1083/jcb.200501141 | url = }}

Further reading

{{cite journal | vauthors = Zhang Y, Koushik S, Dai R, Mivechi NF | title = Structural organization and promoter analysis of murine heat shock transcription factor-1 gene. | journal = J. Biol. Chem. | volume = 273 | issue = 49 | pages = 32514–21 | year = 1999 | pmid = 9829985 | doi = 10.1074/jbc.273.49.32514 }}

{{cite journal | vauthors = Nakatsura T, Senju S, Yamada K, Jotsuka T, Ogawa M, Nishimura Y | title = Gene cloning of immunogenic antigens overexpressed in pancreatic cancer. | journal = Biochem. Biophys. Res. Commun. | volume = 281 | issue = 4 | pages = 936–44 | year = 2001 | pmid = 11237751 | doi = 10.1006/bbrc.2001.4377 }}

{{cite journal | vauthors = Pestov DG, Strezoska Z, Lau LF | title = Evidence of p53-dependent cross-talk between ribosome biogenesis and the cell cycle: effects of nucleolar protein Bop1 on G(1)/S transition. | journal = Mol. Cell. Biol. | volume = 21 | issue = 13 | pages = 4246–55 | year = 2001 | pmid = 11390653 | pmc = 87085 | doi = 10.1128/MCB.21.13.4246-4255.2001 }}

{{cite journal | vauthors = Pestov DG, Stockelman MG, Strezoska Z, Lau LF | title = ERB1, the yeast homolog of mammalian Bop1, is an essential gene required for maturation of the 25S and 5.8S ribosomal RNAs. | journal = Nucleic Acids Res. | volume = 29 | issue = 17 | pages = 3621–30 | year = 2001 | pmid = 11522832 | pmc = 55883 | doi = 10.1093/nar/29.17.3621 }}

{{cite journal | vauthors = Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI | title = Directed proteomic analysis of the human nucleolus. | journal = Curr. Biol. | volume = 12 | issue = 1 | pages = 1–11 | year = 2002 | pmid = 11790298 | doi = 10.1016/S0960-9822(01)00650-9 }}

{{cite journal | vauthors = Strezoska Z, Pestov DG, Lau LF | title = Functional inactivation of the mouse nucleolar protein Bop1 inhibits multiple steps in pre-rRNA processing and blocks cell cycle progression. | journal = J. Biol. Chem. | volume = 277 | issue = 33 | pages = 29617–25 | year = 2002 | pmid = 12048210 | doi = 10.1074/jbc.M204381200 }}

{{cite journal | vauthors = Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ | title = Functional proteomic analysis of human nucleolus. | journal = Mol. Biol. Cell | volume = 13 | issue = 11 | pages = 4100–9 | year = 2003 | pmid = 12429849 | pmc = 133617 | doi = 10.1091/mbc.E02-05-0271 }}

{{cite journal | vauthors = Lapik YR, Fernandes CJ, Lau LF, Pestov DG | title = Physical and functional interaction between Pes1 and Bop1 in mammalian ribosome biogenesis. | journal = Mol. Cell | volume = 15 | issue = 1 | pages = 17–29 | year = 2004 | pmid = 15225545 | doi = 10.1016/j.molcel.2004.05.020 }}

{{cite journal | vauthors = Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M | title = Nucleolar proteome dynamics. | journal = Nature | volume = 433 | issue = 7021 | pages = 77–83 | year = 2005 | pmid = 15635413 | doi = 10.1038/nature03207 }}

{{cite journal | vauthors = Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R | title = Phosphoproteome analysis of the human mitotic spindle. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 103 | issue = 14 | pages = 5391–6 | year = 2006 | pmid = 16565220 | pmc = 1459365 | doi = 10.1073/pnas.0507066103 }}

{{cite journal | vauthors = Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP | title = A probability-based approach for high-throughput protein phosphorylation analysis and site localization. | journal = Nat. Biotechnol. | volume = 24 | issue = 10 | pages = 1285–92 | year = 2006 | pmid = 16964243 | doi = 10.1038/nbt1240 }}

{{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}

{{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry. | journal = Mol. Syst. Biol. | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}

1 : Protein domains

Function

Structure

References

External links

Further reading