“CDP-diacylglycerol—inositol 3-phosphatidyltransferase”的意思、由来-开放百科全书

词条

CDP-diacylglycerol—inositol 3-phosphatidyltransferase

释义

References

{{no footnotes|date=September 2018}}{{enzyme
| Name = CDP-diacylglycerol-inositol 3-phosphatidyltransferase
| EC_number = 2.7.8.11
| CAS_number = 9027-01-4
| IUBMB_EC_number = 2/7/8/11
| GO_code = 0003881
| image =
| width =
| caption =
}}

In enzymology, a CDP-diacylglycerol—inositol 3-phosphatidyltransferase ({{EC number|2.7.8.11}}) is an enzyme that catalyzes the chemical reaction

CDP-diacylglycerol + myo-inositol CMP + phosphatidyl-1D-myo-inositol

Thus, the two substrates of this enzyme are CDP-diacylglycerol and myo-inositol, whereas its two products are CMP and phosphatidyl-1D-myo-inositol.

This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. The systematic name of this enzyme class is CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase. Other names in common use include CDP-diglyceride-inositol phosphatidyltransferase, phosphatidylinositol synthase, CDP-diacylglycerol-inositol phosphatidyltransferase, CDP-diglyceride:inositol transferase, cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:myo-inositol, 3-phosphatidyltransferase, CDP-DG:inositol transferase, cytidine diphosphodiglyceride-inositol phosphatidyltransferase, CDP-diacylglycerol:myo-inositol-3-phosphatidyltransferase, CDP-diglyceride-inositol transferase, cytidine diphosphoglyceride-inositol phosphatidyltransferase, and cytidine diphosphoglyceride-inositol transferase. This enzyme participates in glycerophospholipid metabolism and phosphatidylinositol signaling system.

References

{{cite journal | vauthors = Bleasdale JE, Wallis P, MacDonald PC, Johnston JM | year = 1979 | title = Characterization of the forward and reverse reactions catalyzed by CDP-diacylglycerol:inositol transferase in rabbit lung tissue | journal = Biochim. Biophys. Acta | volume = 575 | pages = 135–47 | pmid = 41587 | issue = 1 | doi=10.1016/0005-2760(79)90139-5}}
{{cite journal | vauthors = Prottey C, Hawthorne JN | year = 1967 | title = The biosynthesis of phosphatidic acid and phosphatidylinositol in mammalian pancreas | journal = Biochem. J. | volume = 105 | pages = 379–92 | pmid = 4293959 | issue = 1 | pmc = 1198310 }}
{{cite journal | vauthors = Salway JG, Harwood JL, Kai M, White GL, Haworne JN | year = 1968 | title = Enzymes of phosphoinositide metabolism during rat brain development | journal = J. Neurochem. | volume = 15 | pages = 221–6 | pmid = 4295616 | doi = 10.1111/j.1471-4159.1968.tb06200.x | issue = 3 }}
{{cite journal | vauthors = Takenawa T, Egawa K | year = 1977 | title = CDP-diglyceride:inositol transferase from rat liver. Purification and properties | journal = J. Biol. Chem. | volume = 252 | pages = 5419–23 | pmid = 18462 | issue = 15 }}

{{Kinases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{DEFAULTSORT:CDP-diacylglycerol-inositol 3-phosphatidyltransferase}}{{2.7-enzyme-stub}}

2 : EC 2.7.8|Enzymes of unknown structure

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