| 词条 | Celiprolol |
| 释义 |
| IUPAC_name = (RS)-N'3-Acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenylN,N-diethylurea | image = Celiprolol.svg | width = 200px | chirality = Racemic mixture | tradename = | Drugs.com = {{drugs.com|international|celiprolol}} | pregnancy_category = | legal_status = | routes_of_administration = | bioavailability = 30-70% | metabolism = | elimination_half-life = 5 hours | excretion = | CAS_number = 56980-93-9 | ATC_prefix = C07 | ATC_suffix = AB08 | PubChem = 2663 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = DB04846 | ChemSpiderID = 2563 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = DRB57K47QC | KEGG = D07660 | ChEMBL = 27810 | C=20 | H=33 | N=3 | O=4 | molecular_weight = 379.49 g/mol | smiles = O=C(N(CC)CC)Nc1ccc(OCC(O)CNC(C)(C)C)c(c1)C(=O)C }} Celiprolol is a medication in the class of beta blockers, used in the treatment of high blood pressure. It has a unique pharmacology: it is a selective β1 receptor antagonist, but a β2 receptor partial agonist. It is also a weak α2 receptor antagonist. Celiprolol is believed to provide clinical benefit for people with vascular Ehlers–Danlos syndrome by promoting normal collagen synthesis in the blood vessels, and by shifting the pressure load away from the vessels most prone to dissection and rupture. [1] Acer Therapeutics is currently developing celiprolol as a potential treatment option specifically for people with vEDS. In 2015, the U.S. Food and Drug Administration (FDA) granted celiprolol orphan drug designation for the treatment of vascular Ehlers–Danlos syndrome. It was patented in 1973 and approved for medical use in 1982.[2] Brand namesBrand names include Cardem, Selectol, Celipres, Celipro, Celol, Cordiax, Dilanorm References1. ^{{cite journal | author = Beridze N, Frishman WH | title = Vascular Ehlers-Danlos syndrome: pathophysiology, diagnosis, and prevention and treatment of its complications | journal = Cardiol Rev. | year = 2012 | doi=10.1097/CRD.0b013e3182342316 | volume = 1 | pages = 4-7 | pmid = 22143279}} 2. ^{{cite book |last1=Fischer |first1=Jnos |last2=Ganellin |first2=C. Robin |title=Analogue-based Drug Discovery |date=2006 |publisher=John Wiley & Sons |isbn=9783527607495 |page=461 |url=https://books.google.ca/books?id=FjKfqkaKkAAC&pg=PA461 |language=en}} External links
5 : Beta blockers|Ureas|Aromatic ketones|Phenol ethers|Alcohols |
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