| 词条 | Histamine receptor | ||||||||||||
| 释义 |
The histamine receptors are a class of G protein–coupled receptors which bind histamine as their primary endogenous ligand.[1] There are four known histamine receptors:
Comparison
There are several splice variants of H3 present in various species. Though all of the receptors are 7-transmembrane g protein coupled receptors, H1 and H2 are quite different from H3 and H4 in their activities. H1 causes an increase in PIP2 hydrolysis, H2 stimulates gastric acid secretion, and H3 mediates feedback inhibition of histamine. References1. ^{{cite journal |vauthors=Hill SJ, Ganellin CR, Timmerman H, Schwartz JC, Shankley NP, Young JM, Schunack W, Levi R, Haas HL | title = International Union of Pharmacology. XIII. Classification of histamine receptors | journal = Pharmacol. Rev. | volume = 49 | issue = 3 | pages = 253–78 | year = 1997 | pmid = 9311023 | doi = | url = http://pharmrev.aspetjournals.org/cgi/content/abstract/49/3/253 }} 2. ^{{cite journal |vauthors=Hofstra CL, Desai PJ, Thurmond RL, Fung-Leung WP | title = Histamine H4 receptor mediates chemotaxis and calcium mobilization of mast cells | journal = J. Pharmacol. Exp. Ther. | volume = 305 | issue = 3 | pages = 1212–21 | year = 2003 | pmid = 12626656 | doi = 10.1124/jpet.102.046581 }} External links
2 : Integral membrane proteins|Histamine receptors |
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