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词条 Cramp fasciculation syndrome
释义

  1. Signs and Symptoms

  2. Diagnosis

  3. Treatment

  4. References

  5. External links

Cramp fasciculation syndrome (CFS) is a rare[1] peripheral nerve hyperexcitability disorder. It is more severe than the related (and common) disorder known as benign fasciculation syndrome; it causes fasciculations, cramps, pain, fatigue, and muscle stiffness similar to those seen in neuromyotonia (another related condition).[2] Patients with CFS, like those with neuromyotonia, may also experience paresthesias.[3]

Most cases of cramp fasciculation syndrome are idiopathic.[4]

Cramp fasciculation syndrome is diagnosed by clinical examination and electromyography (EMG).[5] Fasciculation is the only abnormality[6] (if any)[7] seen with EMG.

Cramp fasciculation syndrome is a chronic condition.[8] Treatment options include anti-seizure medications such as carbamazepine, immunosuppressive drugs and plasmapheresis.[4]

Signs and Symptoms

Symptoms are very similar to those found in benign fasciculation syndrome and include:[9]

  • Fasciculations (Primary Symptom)
  • Muscle cramping (Primary Symptom) [10]
  • Muscle pain
  • Muscle Stiffness
  • Generalized fatigue
  • Anxiety
  • Exercise intolerance
  • Globus sensations
  • Paraesthesias.[11]
  • Hyperreflexia

Diagnosis

The procedure of diagnosis for Cramp Fasciculation Syndrome (CFS) is closely aligned with the diagnosis procedure for benign fasciculation syndrome (BFS). The differentiation between a diagnosis of BFS versus CFS is usually more severe and prominent pain, cramps and stiffness associated with CFS.

Treatment

Treatment is similar to treatment for benign fasciculation syndrome.

Carbamazepine therapy has been found to provide moderate reductions in symptoms.[9]

References

1. ^{{cite journal |last1=Jansen |first1=P. H. P. |last2=Dijck |first2=J. A. A. M. |last3=Verbeek |first3=A. L. M. |last4=Durian |first4=F. W. |last5=Joosten |first5=E. M. G. |title=Estimation of the frequency of the muscular pain-fasciculation syndrome and the muscular cramp-fasciculation syndrome in the adult population |journal=European Archives of Psychiatry and Clinical Neuroscience |volume=241 |issue=2 |pages=102–4 |year=1991 |pmid=1834178 |doi=10.1007/BF02191150}}
2. ^{{cite book |first1=Allan H. |last1=Ropper |first2=Robert H. |last2=Brown |year=2005 |chapter=Disorders of Muscle Characterized by Cramp, Spasm, Pain, and Localized Masses |title=Adams and Victor's Principles of Neurology |edition=8th |publisher=McGraw-Hill |location=New York |pages=1277–8 |isbn=978-0-07-141620-7}}
3. ^{{cite journal |first1=Ian K. |last1=Hart |author-link=Ian Hart (neurologist)|first2=Paul |last2=Maddison |first3=John |last3=Newsom‐Davis |first4=Angela |last4=Vincent |first5=Kerry R. |last5=Mills |title=Phenotypic variants of autoimmune peripheral nerve hyperexcitability |journal=Brain |volume=125 |issue=8 |pages=1887–95 |year=2002 |pmid=12135978 |doi=10.1093/brain/awf178}}
4. ^1 {{cite journal |last1=Lagueny |first1=A |title=Cramp-fasciculation syndrome |journal=Revue Neurologique |volume=161 |issue=12 Pt 1 |pages=1260–6 |year=2005 |pmid=16340924}}
5. ^Washington University in St. Louis, Neuromuscular: Cramp-Fasciculation Syndromes, http://neuromuscular.wustl.edu/mother/activity.html#crampfas
6. ^{{cite journal |last1=Tahmoush |first1=AJ |last2=Alonso |first2=RJ |last3=Tahmoush |first3=GP |last4=Heiman-Patterson |first4=TD |title=Cramp-fasciculation syndrome: a treatable hyperexcitable peripheral nerve disorder |journal=Neurology |volume=41 |issue=7 |pages=1021–4 |year=1991 |pmid=1648679 |doi=10.1212/wnl.41.7.1021}}
7. ^TeleEMG website, Amyotrophic Lateral Sclerosis (ALS)/Motor Neuron Disease, Page 2 {{cite web |url=http://www.teleemg.com/new/als2.htm |title=Archived copy |accessdate=2010-10-27 |deadurl=yes |archiveurl=https://web.archive.org/web/20101129180134/http://teleemg.com/new/als2.htm |archivedate=2010-11-29 |df= }}
8. ^{{cite journal |first1=Manuel |last1=de Entrambasaguas |first2=Juan-José |last2=Ortega-Albás |first3=María-Dolores |last3=Martínez-Lozano |first4=José-Ramón |last4=Díaz |title=Bronchial involvement in the cramp-fasciculation syndrome |journal=European Neurology |volume=56 |issue=2 |pages=124–6 |year=2006 |pmid=16960453 |doi=10.1159/000095703}}
9. ^1 {{Cite journal | pmid = 1648679| year = 1991| author1 = Tahmoush| first1 = A. J.| title = Cramp-fasciculation syndrome: A treatable hyperexcitable peripheral nerve disorder| journal = Neurology| volume = 41| issue = 7| pages = 1021–4| last2 = Alonso| first2 = R. J.| last3 = Tahmoush| first3 = G. P.| last4 = Heiman-Patterson| first4 = T. D. | doi=10.1212/wnl.41.7.1021}}
10. ^{{ cite book | title = Adams and Victor's Principles of Neurology | edition = 8th |author1=Allan H. Ropper |author2=Robert H. Brown | chapter = Chapter 55. Disorders of Muscle | pages = 1277–1278 }}
11. ^{{ cite journal | journal = Brain | volume = 125 | issue = 8 |date=August 2002 | title = Phenotypic Variants of Autoimmune Peripheral Nerve Hyperexcitability | author = Hart, I. | authorlink = Ian Hart (neurologist) |author2=Maddison, P. |author3=Newsom-Davis, J. |author4=Vincent, A. |author5=Mills, K. R. | pages = 1887–1895 | pmid = 12135978 | url = http://brain.oxfordjournals.org/cgi/content/full/125/8/1887 | doi=10.1093/brain/awf178}}

External links

  • https://web.archive.org/web/20110715114849/http://isaacsyndrome.proboards.com/index.cgi

2 : Neurological disorders|Syndromes
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