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词条 CST1
释义

  1. References

  2. External links

  3. Further reading

{{Infobox_gene}}Cystatin-SN is a protein that in humans is encoded by the CST1 gene.[1]

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a cysteine proteinase inhibitor found in saliva, tears, urine, and seminal fluid.[2]

References

1. ^{{cite web | title = Entrez Gene: CST1 cystatin SN| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1469| accessdate = }}
2. ^{{cite web | title = Entrez Gene: CST1 cystatin SN| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1469| accessdate = }}

External links

  • The MEROPS online database for peptidases and their inhibitors: I25.010
  • {{UCSC gene info|CST1}}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors=Brown WM, Dziegielewska KM |title=Friends and relations of the cystatin superfamily--new members and their evolution. |journal=Protein Sci. |volume=6 |issue= 1 |pages= 5–12 |year= 1997 |pmid= 9007972 |doi=10.1002/pro.5560060102 | pmc=2143511 }}
  • {{cite journal | vauthors=Takahashi M, Honda Y, Ogawa K, Barka T |title=Immunofluorescence localization of cystatins in human lacrimal gland and in the exorbital lacrimal gland of the rat. |journal=Acta Ophthalmologica |volume=70 |issue= 5 |pages= 625–31 |year= 1993 |pmid= 1471486 |doi=10.1111/j.1755-3768.1992.tb02143.x }}
  • {{cite journal | vauthors=Isemura S, Saitoh E, Sanada K, Minakata K |title=Identification of full-sized forms of salivary (S-type) cystatins (cystatin SN, cystatin SA, cystatin S, and two phosphorylated forms of cystatin S) in human whole saliva and determination of phosphorylation sites of cystatin S. |journal=J. Biochem. |volume=110 |issue= 4 |pages= 648–54 |year= 1992 |pmid= 1778989 |doi= }}
  • {{cite journal | vauthors=Bobek LA, Aguirre A, Levine MJ |title=Human salivary cystatin S. Cloning, sequence analysis, hybridization in situ and immunocytochemistry. |journal=Biochem. J. |volume=278 |issue= 3|pages= 627–35 |year= 1991 |pmid= 1898352 |doi= | pmc=1151393 }}
  • {{cite journal | vauthors=Al-Hashimi I, Dickinson DP, Levine MJ |title=Purification, molecular cloning, and sequencing of salivary cystatin SA-1. |journal=J. Biol. Chem. |volume=263 |issue= 19 |pages= 9381–7 |year= 1988 |pmid= 2837486 |doi= }}
  • {{cite journal | vauthors=Saitoh E, Isemura S, Sanada K |title=Cystatin superfamily. Evidence that family II cystatin genes are evolutionarily related to family III cystatin genes. |journal=Biol. Chem. Hoppe-Seyler |volume=369 Suppl |issue= |pages= 191–7 |year= 1989 |pmid= 3202964 |doi= |display-authors=etal}}
  • {{cite journal | vauthors=Saitoh E, Kim HS, Smithies O, Maeda N |title=Human cysteine-proteinase inhibitors: nucleotide sequence analysis of three members of the cystatin gene family. |journal=Gene |volume=61 |issue= 3 |pages= 329–38 |year= 1988 |pmid= 3446578 |doi=10.1016/0378-1119(87)90196-X }}
  • {{cite journal | vauthors=Isemura S, Saitoh E, Sanada K |title=Characterization of a new cysteine proteinase inhibitor of human saliva, cystatin SN, which is immunologically related to cystatin S. |journal=FEBS Lett. |volume=198 |issue= 1 |pages= 145–9 |year= 1986 |pmid= 3514272 |doi=10.1016/0014-5793(86)81201-7 }}
  • {{cite journal | vauthors=Dickinson DP, Thiesse M, Dempsey LD, Millar SJ |title=Genomic cloning, physical mapping, and expression of human type 2 cystatin genes. |journal=Crit. Rev. Oral Biol. Med. |volume=4 |issue= 3–4 |pages= 573–80 |year= 1993 |pmid= 7690606 |doi= }}
  • {{cite journal | vauthors=Dickinson DP, Zhao Y, Thiesse M, Siciliano MJ |title=Direct mapping of seven genes encoding human type 2 cystatins to a single site located at 20p11.2 |journal=Genomics |volume=24 |issue= 1 |pages= 172–5 |year= 1995 |pmid= 7896273 |doi= 10.1006/geno.1994.1595 }}
  • {{cite journal | vauthors=Thiesse M, Millar SJ, Dickinson DP |title=The human type 2 cystatin gene family consists of eight to nine members, with at least seven genes clustered at a single locus on human chromosome 20 |journal=DNA Cell Biol. |volume=13 |issue= 2 |pages= 97–116 |year= 1994 |pmid= 8179826 |doi=10.1089/dna.1994.13.97 }}
  • {{cite journal | vauthors=Henskens YM, van der Weijden FA, van den Keijbus PA |title=Effect of periodontal treatment on the protein composition of whole and parotid saliva |journal=J. Periodontol. |volume=67 |issue= 3 |pages= 205–12 |year= 1996 |pmid= 8708950 |doi= 10.1902/jop.1996.67.3.205|display-authors=etal}}
  • {{cite journal | vauthors=Deloukas P, Matthews LH, Ashurst J |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a |display-authors=etal}}
  • {{cite journal | vauthors=Ghafouri B, Ståhlbom B, Tagesson C, Lindahl M |title=Newly identified proteins in human nasal lavage fluid from non-smokers and smokers using two-dimensional gel electrophoresis and peptide mass fingerprinting |journal=Proteomics |volume=2 |issue= 1 |pages= 112–20 |year= 2002 |pmid= 11788998 |doi=10.1002/1615-9861(200201)2:1<112::AID-PROT112>3.0.CO;2-N }}
  • {{cite journal | vauthors=Dickinson DP, Thiesse M, Hicks MJ |title=Expression of type 2 cystatin genes CST1-CST5 in adult human tissues and the developing submandibular gland |journal=DNA Cell Biol. |volume=21 |issue= 1 |pages= 47–65 |year= 2002 |pmid= 11879580 |doi= 10.1089/10445490252810311 }}
  • {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
  • {{cite journal | vauthors=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 | pmc=2286551 }}
  • {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
  • {{cite journal | vauthors=Ito T, Komiya-Ito A, Okuda K |title=Murine monoclonal antibody which can distinguish cystatins SA1 and SA2 |journal=Mol. Immunol. |volume=42 |issue= 10 |pages= 1259–63 |year= 2005 |pmid= 15829315 |doi= 10.1016/j.molimm.2004.11.021 |display-authors=etal}}
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