1. References

2. Further reading

This gene is located within chromosome 9 (9q32-33), a chromosomal region that frequently shows loss of heterozygosity in transitional cell carcinoma of the bladder. It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers.^[3]

The functions of this gene are unknown, and it has not yet been placed in a protein family or functional pathway. Nonetheless, it is suspected to act as a tumor suppressor gene.

References

Further reading

• {{cite journal | vauthors=Auffray C, Behar G, Bois F |title=[IMAGE: molecular integration of the analysis of the human genome and its expression] |journal=Comptes Rendus de l'Académie des Sciences, Série III |volume=318 |issue= 2 |pages= 263–72 |year= 1995 |pmid= 7757816 |doi= |display-authors=etal}}
• {{cite journal | vauthors=Habuchi T, Luscombe M, Elder PA, Knowles MA |title=Structure and methylation-based silencing of a gene (DBCCR1) within a candidate bladder cancer tumor suppressor region at 9q32-q33. |journal=Genomics |volume=48 |issue= 3 |pages= 277–88 |year= 1998 |pmid= 9545632 |doi= 10.1006/geno.1997.5165 }}
• {{cite journal | vauthors=Nishiyama H, Takahashi T, Kakehi Y |title=Homozygous deletion at the 9q32-33 candidate tumor suppressor locus in primary human bladder cancer. |journal=Genes Chromosomes Cancer |volume=26 |issue= 2 |pages= 171–5 |year= 2000 |pmid= 10469456 |doi=10.1002/(SICI)1098-2264(199910)26:2<171::AID-GCC10>3.0.CO;2-B |display-authors=etal}}
• {{cite journal | vauthors=Nishiyama H, Gill JH, Pitt E |title=Negative regulation of G(1)/S transition by the candidate bladder tumour suppressor gene DBCCR1. |journal=Oncogene |volume=20 |issue= 23 |pages= 2956–64 |year= 2001 |pmid= 11420708 |doi= 10.1038/sj.onc.1204432 |display-authors=etal}}
• {{cite journal | vauthors=Wright KO, Messing EM, Reeder JE |title=Increased expression of the acid sphingomyelinase-like protein ASML3a in bladder tumors. |journal=J. Urol. |volume=168 |issue= 6 |pages= 2645–9 |year= 2002 |pmid= 12442002 |doi= 10.1016/s0022-5347(05)64236-x}}
• {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
• {{cite journal | vauthors=Wright KO, Messing EM, Reeder JE |title=DBCCR1 mediates death in cultured bladder tumor cells. |journal=Oncogene |volume=23 |issue= 1 |pages= 82–90 |year= 2004 |pmid= 14712213 |doi= 10.1038/sj.onc.1206642 }}
• {{cite journal | vauthors=Humphray SJ, Oliver K, Hunt AR |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 | pmc=2734081 |display-authors=etal}}
• {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
• {{cite journal | vauthors=Beetz C, Brodoehl S, Patt S |title=Low expression but infrequent genomic loss of the putative tumour suppressor DBCCR1 in astrocytoma. |journal=Oncol. Rep. |volume=13 |issue= 2 |pages= 335–40 |year= 2005 |pmid= 15643521 |doi= 10.3892/or.13.2.335|display-authors=etal|doi-broken-date=2018-11-07 }}
• {{cite journal | vauthors=Izumi H, Inoue J, Yokoi S |title=Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers. |journal=Hum. Mol. Genet. |volume=14 |issue= 8 |pages= 997–1007 |year= 2005 |pmid= 15746151 |doi= 10.1093/hmg/ddi092 |display-authors=etal}}
• {{cite journal | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
• {{cite journal | vauthors=Louhelainen JP, Hurst CD, Pitt E |title=DBC1 re-expression alters the expression of multiple components of the plasminogen pathway. |journal=Oncogene |volume=25 |issue= 16 |pages= 2409–19 |year= 2006 |pmid= 16369496 |doi= 10.1038/sj.onc.1209228 |display-authors=etal}}

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