| 词条 | Imperatorin |
| 释义 |
| Verifiedfields = changed | verifiedrevid = 443870625 | ImageFile=Imperatorin.png | ImageSize=200px | IUPACName=9-(3-Methylbut-2-enoxy)-7-furo[3,2-g]chromenone | OtherNames=Ammidin Marmelosin Pentosalen 8-Isoamylenoxypsoralen 8-Isopentenyloxypsoralene |Section1={{Chembox Identifiers | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 9797 | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = C09269 | InChI = 1/C16H14O4/c1-10(2)5-7-19-16-14-12(6-8-18-14)9-11-3-4-13(17)20-15(11)16/h3-6,8-9H,7H2,1-2H3 | InChIKey = OLOOJGVNMBJLLR-UHFFFAOYAQ | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 453805 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C16H14O4/c1-10(2)5-7-19-16-14-12(6-8-18-14)9-11-3-4-13(17)20-15(11)16/h3-6,8-9H,7H2,1-2H3 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = OLOOJGVNMBJLLR-UHFFFAOYSA-N | CASNo_Ref = {{cascite|correct|??}} | CASNo=482-44-0 | PubChem=10212 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = K713N25C78 | ChEBI_Ref = {{ebicite|changed|EBI}} | ChEBI = 5885 | SMILES=O=C/3Oc2c(OC\\C=C(/C)C)c1occc1cc2\\C=C\\3 }} |Section2={{Chembox Properties | Formula=C16H14O4 | MolarMass=270.28 g/mol | Appearance= | Density= | MeltingPt= | BoilingPt= | Solubility= }} |Section3={{Chembox Hazards | MainHazards= | FlashPt= | AutoignitionPt = }} }}Imperatorin is a furocoumarin and a phytochemical that has been isolated from Urena lobata L. (Malvaceae), Angelica archangelica,[1] Angelica dahurica,[2] Glehnia littoralis,[3] Saposhnikovia divaricata,[4] Cnidium monnieri,[5] Incarvillea younghusbandii,[6] and Zanthoxylum americanum mill.[7] It is biosynthesized from umbelliferone, a coumarin derivative.[8] IsolationThe procedure for the isolation of imperatorin from Urena lobata involves exhaustively extracting under reflux with benzene the air-dried and pulverised roots followed by separation by column chromatography.[9] Biochemical activityImperatorin was identified from a Bioactive Molecules library in a high throughput screening experiment for inhibitors of the phosphodiesterase PDE4. It displays a significant preference for PDE4B over PDE4A.[10] See also
References1. ^{{cite journal |vauthors=Sigurdsson S, Ogmundsdottir HM, Gudbjarnason S |date=July–August 2004 |title=Antiproliferative effect of Angelica archangelica fruits. |journal=Zeitschrift für Naturforschung C |volume=59 |series=4th |issue=7–8 |pages=523–7 |pmid=15813373 |doi=10.1515/znc-2004-7-813}} {{coumarin}}2. ^{{cite journal |vauthors=Xie Y, Zhao W, Zhou T, Fan G, Wu Y |date=September–October 2010 |title=An efficient strategy based on MAE, HPLC-DAD-ESI-MS/MS and 2D-prep-HPLC-DAD for the rapid extraction, separation, identification and purification of five active coumarin components from Radix Angelicae Dahuricae |journal=Phytochemical Analysis |volume=21 |issue=5 |pages=473–82 |pmid=20931624 |doi=10.1002/pca.1222}} 3. ^{{cite journal | vauthors = Liu M, Shi X, Yang W, Liu S, Wang N, Shi R, Qiao S, Wang Q, Wang Y | title = Quantitative analysis of nine coumarins in rat urine and bile after oral administration of Radix Glehniae extract by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry | journal = Biomed. Chromatogr. | volume = 25 | issue = 7 | pages = 783–93 | date = July 2011 | pmid = 20878664 | doi = 10.1002/bmc.1517 }} 4. ^{{cite journal |vauthors=Zhao B, Yang X, Yang X, Zhang L |date=June 2010 |trans-title=Chemical constituents of roots of Saposhnikovia divaricata |journal=Zhongguo Zhong yao za zhi |volume=35 |series=2nd |issue=12 |pages=1569–72 |pmid=20815209 |language=Chinese|title=Chemical constituents of roots of Saposhnikovia divaricata}} 5. ^{{cite journal | last = Shin | first = Eunjin |author2=Lee, Chul |author3=Sung, Sang Hyun |author4=Kim, Young Choong |author5=Hwang, Bang Yeon |author6= Lee, Mi Kyeong. | date = 2010-11-17 | title = Antifibrotic activity of coumarins from Cnidium monnieri fruits in HSC-T6 hepatic stellate cells | journal = Journal of Natural Medicines | volume = 65| series = | pmid = 21082271 | doi = 10.1007/s11418-010-0485-7 | url = http://www.springerlink.com/content/uj881g010mt00287/fulltext.pdf | accessdate = 2010-11-27 | issue = 2 | pages = 370–374}} 6. ^{{cite journal | last = Fu | first = Y |author2=Bai Y |author3=Dawa Z |author4=Bai B |author5=Ding L. |date=January 2010 |trans-title=Chemical constituents of Incarvillea younghusbandii | journal = Zhongguo Zhong yao za zhi | volume = 35 | series = 2nd | issue=1 | pmid=20349717 | title = Chemical constituents of Incarvillea younghusbandii | pages = 58–62}} 7. ^{{cite journal | last=Bafi-Yeboa | first=N. F. |author2=Arnason JT |author3=Baker J |author4=Smith ML. |date=May 2005 | title=Antifungal constituents of northern prickly ash, Zanthoxylum americanum mill | journal=Phytomedicine | volume=12 | issue=5 | pmid=15957372 | pages=370–7 | doi=10.1016/j.phymed.2003.12.005}} 8. ^F. M. Dean Naturally Occurring Oxygen Ring Compounds, Butterworths, London, 1963. 9. ^A furocoumarin, Imperatorin isolated from Urena lobata L. (Malvaceae) Keshab Ghosh Molbank 2004, M382 open access publication 10. ^{{cite journal | vauthors = Ivey FD, Wang L, Demirbas D, Allain C, Hoffman CS | title = Development of a fission yeast-based high-throughput screen to identify chemical regulators of cAMP phosphodiesterases | journal = J Biomol Screen | volume = 13 | issue = 1 | pages = 62–71 | date = January 2008 | pmid = 18227226 | pmc = 2851203 | doi = 10.1177/1087057107312127 }} 3 : Furanocoumarins|Terpeno-phenolic compounds|Phenol ethers |
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