| 词条 | Intercellular adhesion molecule |
| 释义 |
| Symbol = ICAM_N | Name = Intercellular adhesion molecule (ICAM), N-terminal domain | image = PDB 1iam EBI.jpg | width = | caption = structure of the two amino-terminal domains of human intercellular adhesion molecule-1, icam-1 | Pfam = PF03921 | Pfam_clan = CL0011 | InterPro = IPR013768 | SMART = | PROSITE = | MEROPS = | SCOP = 1zxq | TCDB = | OPM family = | OPM protein = | CAZy = | CDD = | Membranome family = 219 }} In molecular biology, intercellular adhesion molecules (ICAMs) and vascular cell adhesion molecule-1 (VCAM-1) are part of the immunoglobulin superfamily. They are important in inflammation, immune responses and in intracellular signalling events.[1] The ICAM family consists of five members, designated ICAM-1 to ICAM-5. They are known to bind to leucocyte integrins CD11/CD18 such as LFA-1 and Macrophage-1 antigen, during inflammation and in immune responses. In addition, ICAMs may exist in soluble forms in human plasma, due to activation and proteolysis mechanisms at cell surfaces. Mammalian intercellular adhesion molecules include:
References1. ^{{cite journal |vauthors=Gahmberg CG, Tolvanen M, Kotovuori P | title = Leukocyte adhesion--structure and function of human leukocyte beta2-integrins and their cellular ligands | journal = Eur. J. Biochem. | volume = 245 | issue = 2 | pages = 215–32 |date=April 1997 | pmid = 9151947 | doi = 10.1111/j.1432-1033.1997.00215.x| url = }} {{InterPro content|IPR013768}}{{Cell adhesion molecules}}{{Biochem-stub}} 2 : Cell biology|Protein families |
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