1. Function

2. See also

3. References

4. Further reading

5. External links

Low affinity immunoglobulin gamma Fc region receptor II-b is a protein that, in humans, is encoded by the FCGR2B gene. FCGR2B (CD32B) is a "low affinity" receptor for Immunoglobulin G (IgG). Mutation in the gene in humans leads to a lupus phenotype.^[1][2] The cytoplasmic part of this receptor contains an immunoreceptor tyrosine-based inhibitory motif, in contrast to the activating isoform, FCGR2A (CD32A).

Function

The inhibitory CD32B is expressed on B cells and myeloid dendritic cells.^[3] Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target for monoclonal antibody therapy for malignancies.^[4][5]

See also

• CD32

References

Further reading

• {{cite journal | vauthors=Tsuchiya N, Kyogoku C |title=Role of Fc gamma receptor IIb polymorphism in the genetic background of systemic lupus erythematosus: insights from Asia. |journal=Autoimmunity |volume=38 |issue= 5 |pages= 347–52 |year= 2005 |pmid= 16227149 |doi= 10.1080/08916930500123926 }}
• {{cite journal | vauthors=Engelhardt W, Geerds C, Frey J |title=Distribution, inducibility and biological function of the cloned and expressed human beta Fc receptor II. |journal=Eur. J. Immunol. |volume=20 |issue= 6 |pages= 1367–77 |year= 1990 |pmid= 2142460 |doi=10.1002/eji.1830200624 }}
• {{cite journal | author=Seki T |title=Identification of multiple isoforms of the low-affinity human IgG Fc receptor. |journal=Immunogenetics |volume=30 |issue= 1 |pages= 5–12 |year= 1989 |pmid= 2526077 |doi=10.1007/BF02421463 }}
• {{cite journal | vauthors=Brooks DG, Qiu WQ, Luster AD, Ravetch JV |title=Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes. |journal=J. Exp. Med. |volume=170 |issue= 4 |pages= 1369–85 |year= 1989 |pmid= 2529342 |doi=10.1084/jem.170.4.1369 | pmc=2189488 }}
• {{cite journal | vauthors=Stuart SG, Simister NE, Clarkson SB |title=Human IgG Fc receptor (hFcRII; CD32) exists as multiple isoforms in macrophages, lymphocytes and IgG-transporting placental epithelium. |journal=EMBO J. |volume=8 |issue= 12 |pages= 3657–66 |year= 1990 |pmid= 2531080 |doi= 10.1002/j.1460-2075.1989.tb08540.x| pmc=402048 |display-authors=etal}}
• {{cite journal | vauthors=Stengelin S, Stamenkovic I, Seed B |title=Isolation of cDNAs for two distinct human Fc receptors by ligand affinity cloning. |journal=EMBO J. |volume=7 |issue= 4 |pages= 1053–9 |year= 1988 |pmid= 3402431 |doi= 10.1002/j.1460-2075.1988.tb02913.x| pmc=454434 }}
• {{cite journal | vauthors=Engelhardt W, Matzke J, Schmidt RE |title=Activation-dependent expression of low affinity IgG receptors Fc gamma RII(CD32) and Fc gamma RIII(CD16) in subpopulations of human T lymphocytes. |journal=Immunobiology |volume=192 |issue= 5 |pages= 297–320 |year= 1995 |pmid= 7649565 |doi= 10.1016/s0171-2985(11)80172-5}}
• {{cite journal | vauthors=D'Ambrosio D, Hippen KL, Minskoff SA |title=Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by Fc gamma RIIB1. |journal=Science |volume=268 |issue= 5208 |pages= 293–7 |year= 1995 |pmid= 7716523 |doi=10.1126/science.7716523 |display-authors=etal}}
• {{cite journal | vauthors=Warmerdam PA, van den Herik-Oudijk IE, Parren PW |title=Interaction of a human Fc gamma RIIb1 (CD32) isoform with murine and human IgG subclasses. |journal=Int. Immunol. |volume=5 |issue= 3 |pages= 239–47 |year= 1993 |pmid= 8466861 |doi=10.1093/intimm/5.3.239 |display-authors=etal}}
• {{cite journal | vauthors=Bewarder N, Weinrich V, Budde P |title=In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation. |journal=Mol. Cell. Biol. |volume=16 |issue= 9 |pages= 4735–43 |year= 1996 |pmid= 8756631 |doi= 10.1128/MCB.16.9.4735| pmc=231474 |display-authors=etal}}
• {{cite journal | vauthors=Sandilands GP, MacPherson SA, Burnett ER |title=Differential expression of CD32 isoforms following alloactivation of human T cells. |journal=Immunology |volume=91 |issue= 2 |pages= 204–11 |year= 1997 |pmid= 9227318 |doi=10.1046/j.1365-2567.1997.00241.x | pmc=1363848 |display-authors=etal}}
• {{cite journal | vauthors=De SK, Venkateshan CN, Seth P |title=Adenovirus-mediated human immunodeficiency virus-1 Nef expression in human monocytes/macrophages and effect of Nef on downmodulation of Fcgamma receptors and expression of monokines. |journal=Blood |volume=91 |issue= 6 |pages= 2108–17 |year= 1998 |pmid= 9490697 |doi= |display-authors=etal}}
• {{cite journal | vauthors=Metes D, Ernst LK, Chambers WH |title=Expression of functional CD32 molecules on human NK cells is determined by an allelic polymorphism of the FcgammaRIIC gene. |journal=Blood |volume=91 |issue= 7 |pages= 2369–80 |year= 1998 |pmid= 9516136 |doi= |display-authors=etal}}
• {{cite journal | vauthors=Sondermann P, Huber R, Jacob U |title=Crystal structure of the soluble form of the human fcgamma-receptor IIb: a new member of the immunoglobulin superfamily at 1.7 A resolution. |journal=EMBO J. |volume=18 |issue= 5 |pages= 1095–103 |year= 1999 |pmid= 10064577 |doi= 10.1093/emboj/18.5.1095 | pmc=1171201 }}
• {{cite journal | vauthors=Muraille E, Bruhns P, Pesesse X |title=The SH2 domain containing inositol 5-phosphatase SHIP2 associates to the immunoreceptor tyrosine-based inhibition motif of Fc gammaRIIB in B cells under negative signaling. |journal=Immunol. Lett. |volume=72 |issue= 1 |pages= 7–15 |year= 2000 |pmid= 10789675 |doi=10.1016/S0165-2478(00)00162-0 |display-authors=etal}}
• {{cite journal | vauthors=Pricop L, Redecha P, Teillaud JL |title=Differential modulation of stimulatory and inhibitory Fc gamma receptors on human monocytes by Th1 and Th2 cytokines. |journal=J. Immunol. |volume=166 |issue= 1 |pages= 531–7 |year= 2001 |pmid= 11123333 |doi= 10.4049/jimmunol.166.1.531|display-authors=etal}}
• {{cite journal | vauthors=Lyden TW, Robinson JM, Tridandapani S |title=The Fc receptor for IgG expressed in the villus endothelium of human placenta is Fc gamma RIIb2. |journal=J. Immunol. |volume=166 |issue= 6 |pages= 3882–9 |year= 2001 |pmid= 11238632 |doi= 10.4049/jimmunol.166.6.3882|display-authors=etal}}
• {{cite journal | vauthors=Bharadwaj D, Mold C, Markham E, Du Clos TW |title=Serum amyloid P component binds to Fc gamma receptors and opsonizes particles for phagocytosis. |journal=J. Immunol. |volume=166 |issue= 11 |pages= 6735–41 |year= 2001 |pmid= 11359830 |doi= 10.4049/jimmunol.166.11.6735}}
• {{cite journal | vauthors=Jessup CF, Ridings J, Ho A |title=The Fc receptor for IgG (Fc gamma RII; CD32) on human neonatal B lymphocytes. |journal=Hum. Immunol. |volume=62 |issue= 7 |pages= 679–85 |year= 2001 |pmid= 11423173 |doi=10.1016/S0198-8859(01)00257-9 |display-authors=etal}}

External links

• {{MeshName|FCGR2B+protein,+human}}

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