| 词条 | Irwin Rose |
| 释义 |
|name = Irwin Rose | birth_name = Irwin Allan Rose |image = Nobel2004chemistrylaurets-Rose.jpg |image_size = |caption=Irwin Rose, c. 2000 |birth_date = {{birth date|mf=yes|1926|7|16}} |birth_place = Brooklyn, New York, U.S. |death_date={{death date and age|2015|6|2|1926|6|16}} |death_place=Deerfield, Massachusetts, U.S. |nationality = United States |field = Biology |work_institutions = {{Plainlist|
|alma_mater = University of Chicago (BS, PhD) NYU (postdoc) |doctoral_advisor = |doctoral_students = |known_for = Ubiquitin-mediated protein degradation |influences = |influenced = |prizes = Nobel Prize in Chemistry (2004) |spouse=Zelda Budenstein{{citation needed|date=July 2015}} | children = 4{{citation needed|date=July 2015}} }}Irwin Allan Rose (July 16, 1926 – June 2, 2015) was an American biologist. Along with Aaron Ciechanover and Avram Hershko, he was awarded the 2004 Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation.[1][2][3][4][5][6][7] Education and early lifeRose was born in Brooklyn, New York, into a secular Jewish family, the son of Ella (Greenwald) and Harry Royze, who owned a flooring store.[8] Rose attended Washington State University for one year prior to serving in the Navy during World War II. Upon returning from the war he received his Bachelor of Science degree in 1948 and his PhD in biochemistry in 1952, both from the University of Chicago.[9] He did his post-doctoral studies at NYU.[9] Career and researchRose served on the faculty of Yale School of Medicine's department of biochemistry from 1954 to 1963. He then joined the Fox Chase Cancer Center in 1963 and stayed there until he retired in 1995.[10] He joined University of Pennsylvania during the 1970s and served as a Professor of Physical Biochemistry.[11] He was a distinguished professor-in-residence in the Department of Physiology and Biophysics at the University of California, Irvine School of Medicine at the time his Nobel Prize was announced in 2004.[10] Irwin (Ernie) trained several postdoctoral research fellows while at the Fox Chase Cancer Center in Philadelphia. These included Art Haas,[12] the first to see Ubiquitin chains, Keith Wilkinson,[1] the one to first identify APF-1 as Ubiquitin, and Cecile Pickart,[13] a world class enzymologist in many parts of the Ub system. Awards and honorsRose was awarded the Nobel prize in 2004.[14][15][16] Personal lifeRose was married to Zelda Budenstein and had four children.[17] He died on June 2, 2015 at Deerfield, Massachusetts.[17][18] References1. ^1 {{cite journal|last1=Wilkinson|first1=Keith|last2=Hershko|first2=Avram|title=Irwin Allan Rose (1926–2015) Established role of ubiquitin in the destruction of cellular proteins|journal=Nature|volume=523|issue=7562|year=2015|pages=532–532|issn=0028-0836|doi=10.1038/523532a}} {{Commons category}}{{Nobel Prize in Chemistry Laureates 2001–2025}}{{2004 Nobel Prize winners}}{{Authority control}}{{DEFAULTSORT:Rose, Irwin}}2. ^{{Citation | pmid=16094392 | last=Rose | first=Irwin | year=2005 | title=Early work on the ubiquitin proteasome system, an interview with Irwin Rose. Interview by CDD | volume=12 | issue=9 | periodical=Cell Death Differ. | pages=1162–6 | doi=10.1038/sj.cdd.4401700}} 3. ^{{Citation | pmid=15881872 | year=2005 | title=Nobel Prize in Chemistry, 2004. Aaron Ciechanover, Avram Hershko and Irwin Rose | volume=49 | issue=1 | periodical=Indian J. Physiol. Pharmacol. | pages=121}} 4. ^{{Citation | pmid=15700582 | last=Latonen | first=Leena | last2=Laiho | first2=Marikki | publication-date=2004 | year=2004 | title=Nobel prize in chemistry goes to three persons with a key role in revealing the ubiquitin-mediated protein degradation pathway | volume=120 | issue=24 | periodical=Duodecim; lääketieteellinen aikakauskirja | pages=2868–71}} 5. ^{{Citation | pmid=15694320 | last=Goldberg | first=Alfred L | publication-date=Feb 3, 2005 | year=2005 | title=Nobel committee tags ubiquitin for distinction | volume=45 | issue=3 | periodical=Neuron | pages=339–44 | doi=10.1016/j.neuron.2005.01.019}} 6. ^{{Citation | pmid=15646859 | last=Neefjes | first=J | last2=Groothuis | first2=T A M | last3=Dantuma | first3=N P | publication-date=Dec 25, 2004 | year=2004 | title=The 2004 Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation | volume=148 | issue=52 | periodical=Nederlands tijdschrift voor geneeskunde | pages=2579–82}} 7. ^{{Citation | doi = 10.1073/pnas.76.7.3107 | last1 = Hershko | first1 = A. | last2 = Ciechanover | first2 = A. | last3 = Rose | first3 = I.A. | year = 1979 | title = Resolution of the ATP-dependent proteolytic system from reticulocytes: a component that interacts with ATP | url = | journal = Proc. Natl. Acad. Sci. USA | volume = 76 | issue = 7| pages = 3107–3110 | pmid = 290989 | pmc = 383772 | postscript = . }} 8. ^[https://www.nobelprize.org/nobel_prizes/chemistry/laureates/2004/rose.html Nobelprize.org - Irwin Rose Autobiography] 9. ^https://web.archive.org/web/20160423040948/http://www.nobelprize.org/nobel_prizes/chemistry/laureates/2004/rose-bio.html 10. ^1 {{cite web | url=https://www.washingtonpost.com/national/health-science/irwin-rose-who-shared-2004-nobel-prize-in-chemistry-dies-at-88/2015/06/03/671a2ece-0996-11e5-95fd-d580f1c5d44e_story.html | title=Irwin Rose, who shared 2004 Nobel Prize in chemistry, dies at 88 | work=Washington Post | date=3 June 2015 | accessdate=4 June 2015 | author=Weil, Martin}} 11. ^{{cite web | url=http://www.archives.upenn.edu/people/notables/awards/nobel.html | title=Selected Awards and Honors to Penn Faculty and Alumni: Nobel Prizes | work=University of Pennsylvania Website | accessdate=4 June 2015}} 12. ^{{Citation | doi = 10.1073/pnas.77.4.1783 | last1 = Hershko | first1 = A. | last2 = Ciechanover | first2 = A. | last3 = Heller | first3 = H. | last4 = Haas | first4 = A.L. | last5 = Rose | first5 = I.A. | year = 1980 | title = Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis | url = | journal = Proc. Natl. Acad. Sci. USA | volume = 77 | issue = 4| pages = 1783–1786 | pmid = 6990414 | pmc = 348591 | postscript = . }} 13. ^{{Citation | pmid=15486272 | last=Vogel | first=Gretchen | publication-date=Oct 15, 2004 | year=2004 | title=Nobel Prizes. Gold medal from cellular trash | volume=306 | issue=5695 | periodical=Science | pages=400–1 | doi=10.1126/science.306.5695.400b }} 14. ^Nobel citation 15. ^Rose Nobel Prize lecture 16. ^{{Citation | pmid=15483574 | last=Giles | first=Jim | publication-date=Oct 14, 2004 | year=2004 | title=Chemistry Nobel for trio who revealed molecular death-tag | volume=431 | issue=7010 | periodical=Nature | pages=729 | doi=10.1038/431729a}} 17. ^1 2 {{cite web | url=https://www.nytimes.com/2015/06/03/science/irwin-rose-nobel-winning-biochemist-dies-at-88.html | title=Irwin A. Rose, Nobel-Winning Biochemist, Dies at 88 | work=New York Times | date=2 June 2015 | accessdate=4 June 2015 | author=Chang, Kenneth}} 18. ^{{cite web|url=http://abcnews.go.com/Technology/wireStory/2004-nobel-chemistry-winner-irwin-rose-dies-88-31483881|title=2004 Nobel Chemistry Winner Irwin Rose Dies at 88|author=ABC News|work=ABC News}} 11 : 1926 births|2015 deaths|American biologists|American Nobel laureates|Jewish American scientists|Members of the United States National Academy of Sciences|Nobel laureates in Chemistry|People from Spokane, Washington|University of California, Irvine faculty|University of Chicago alumni|American military personnel of World War II |
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