| 释义 |
- References
- Further reading
{{Infobox_gene}}Protein farnesyltransferase subunit beta is an enzyme that in humans is encoded by the FNTB gene.[1][2]References1. ^{{cite journal |vauthors=Andres DA, Milatovich A, Ozcelik T, Wenzlau JM, Brown MS, Goldstein JL, Francke U | title = cDNA cloning of the two subunits of human CAAX farnesyltransferase and chromosomal mapping of FNTA and FNTB loci and related sequences | journal = Genomics | volume = 18 | issue = 1 | pages = 105–12 |date=Feb 1994 | pmid = 8276393 | pmc = | doi = 10.1006/geno.1993.1432 }}
2. ^{{cite web | title = Entrez Gene: FNTB farnesyltransferase, CAAX box, beta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2342| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Manne V, Roberts D, Tobin A |title=Identification and preliminary characterization of protein-cysteine farnesyltransferase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 19 |pages= 7541–5 |year= 1990 |pmid= 2217184 |doi=10.1073/pnas.87.19.7541 | pmc=54783 |display-authors=etal}}
- {{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
- {{cite journal |vauthors=Sinensky M, Fantle K, Trujillo M |title=The processing pathway of prelamin A |journal=J. Cell Sci. |volume=107 |issue= 1|pages= 61–7 |year= 1994 |pmid= 8175923 |doi= |display-authors=etal}}
- {{cite journal |vauthors=Omer CA, Kral AM, Diehl RE |title=Characterization of recombinant human farnesyl-protein transferase: cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases |journal=Biochemistry |volume=32 |issue= 19 |pages= 5167–76 |year= 1993 |pmid= 8494894 |doi=10.1021/bi00070a028 |display-authors=etal}}
- {{cite journal |vauthors=Wang T, Danielson PD, Li BY |title=The p21(RAS) farnesyltransferase alpha subunit in TGF-beta and activin signaling |journal=Science |volume=271 |issue= 5252 |pages= 1120–2 |year= 1996 |pmid= 8599089 |doi=10.1126/science.271.5252.1120 |display-authors=etal}}
- {{cite journal |vauthors=Nantais DE, Schwemmle M, Stickney JT |title=Prenylation of an interferon-gamma-induced GTP-binding protein: the human guanylate binding protein, huGBP1 |journal=J. Leukoc. Biol. |volume=60 |issue= 3 |pages= 423–31 |year= 1996 |pmid= 8830800 |doi= |display-authors=etal}}
- {{cite journal |vauthors=Goalstone ML, Draznin B |title=Effect of insulin on farnesyltransferase activity in 3T3-L1 adipocytes |journal=J. Biol. Chem. |volume=271 |issue= 44 |pages= 27585–9 |year= 1996 |pmid= 8910345 |doi=10.1074/jbc.271.44.27585 }}
- {{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
- {{cite journal |vauthors=Long SB, Casey PJ, Beese LS |title=Cocrystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate substrate |journal=Biochemistry |volume=37 |issue= 27 |pages= 9612–8 |year= 1998 |pmid= 9657673 |doi= 10.1021/bi980708e }}
- {{cite journal |vauthors=Prakash B, Praefcke GJ, Renault L |title=Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins |journal=Nature |volume=403 |issue= 6769 |pages= 567–71 |year= 2000 |pmid= 10676968 |doi= 10.1038/35000617 |display-authors=etal}}
- {{cite journal |vauthors=Zeng Q, Si X, Horstmann H |title=Prenylation-dependent association of protein-tyrosine phosphatases PRL-1, -2, and -3 with the plasma membrane and the early endosome |journal=J. Biol. Chem. |volume=275 |issue= 28 |pages= 21444–52 |year= 2000 |pmid= 10747914 |doi= 10.1074/jbc.M000453200 |display-authors=etal}}
- {{cite journal |vauthors=Ashar HR, James L, Gray K |title=Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules |journal=J. Biol. Chem. |volume=275 |issue= 39 |pages= 30451–7 |year= 2000 |pmid= 10852915 |doi= 10.1074/jbc.M003469200 |display-authors=etal}}
- {{cite journal |vauthors=Guenzi E, Töpolt K, Cornali E |title=The helical domain of GBP-1 mediates the inhibition of endothelial cell proliferation by inflammatory cytokines |journal=EMBO J. |volume=20 |issue= 20 |pages= 5568–77 |year= 2001 |pmid= 11598000 |doi= 10.1093/emboj/20.20.5568 | pmc=125279 |display-authors=etal}}
- {{cite journal |vauthors=Long SB, Hancock PJ, Kral AM |title=The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 23 |pages= 12948–53 |year= 2001 |pmid= 11687658 |doi= 10.1073/pnas.241407898 | pmc=60805 |display-authors=etal}}
- {{cite journal |vauthors=Lobell RB, Omer CA, Abrams MT |title=Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models |journal=Cancer Res. |volume=61 |issue= 24 |pages= 8758–68 |year= 2002 |pmid= 11751396 |doi= |display-authors=etal}}
- {{cite journal |vauthors=Bell IM, Gallicchio SN, Abrams M |title=3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency |journal=J. Med. Chem. |volume=45 |issue= 12 |pages= 2388–409 |year= 2002 |pmid= 12036349 |doi=10.1021/jm010531d |display-authors=etal}}
- {{cite journal |vauthors=Long SB, Casey PJ, Beese LS |title=Reaction path of protein farnesyltransferase at atomic resolution |journal=Nature |volume=419 |issue= 6907 |pages= 645–50 |year= 2002 |pmid= 12374986 |doi= 10.1038/nature00986 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
- {{cite journal |vauthors=deSolms SJ, Ciccarone TM, MacTough SC |title=Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents |journal=J. Med. Chem. |volume=46 |issue= 14 |pages= 2973–84 |year= 2003 |pmid= 12825937 |doi= 10.1021/jm020587n |display-authors=etal}}
{{refend}}{{PDB Gallery|geneid=2342}}{{gene-14-stub}} |