| 释义 |
- References
- Further reading
- External links
{{Infobox_gene}}Homeobox protein Hox-D8 is a protein that in humans is encoded by the HOXD8 gene.[1][2][3]{{PBB_Summary
| section_title =
| summary_text = This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function.[3]
}}References1. ^{{cite journal |vauthors=McAlpine PJ, Shows TB | title = Nomenclature for human homeobox genes | journal = Genomics | volume = 7 | issue = 3 | pages = 460 |date=Aug 1990 | pmid = 1973146 | pmc = | doi =10.1016/0888-7543(90)90186-X }}
2. ^{{cite journal | author = Scott MP | title = Vertebrate homeobox gene nomenclature | journal = Cell | volume = 71 | issue = 4 | pages = 551–3 |date=Dec 1992 | pmid = 1358459 | pmc = | doi =10.1016/0092-8674(92)90588-4 }}
3. ^1 {{cite web | title = Entrez Gene: HOXD8 homeobox D8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3234| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal | author=Goodman FR |title=Limb malformations and the human HOX genes. |journal=Am. J. Med. Genet. |volume=112 |issue= 3 |pages= 256–65 |year= 2003 |pmid= 12357469 |doi= 10.1002/ajmg.10776 }}
- {{cite journal |vauthors=Redline RW, Williams AJ, Patterson P, Collins T |title=Human HOX4E: a gene strongly expressed in the adult male and female urogenital tracts. |journal=Genomics |volume=13 |issue= 2 |pages= 425–30 |year= 1992 |pmid= 1351871 |doi=10.1016/0888-7543(92)90263-R }}
- {{cite journal |vauthors=Oliver G, Sidell N, Fiske W, etal |title=Complementary homeo protein gradients in developing limb buds. |journal=Genes Dev. |volume=3 |issue= 5 |pages= 641–50 |year= 1989 |pmid= 2568311 |doi=10.1101/gad.3.5.641 }}
- {{cite journal |vauthors=Manohar CF, Salwen HR, Furtado MR, Cohn SL |title=Up-regulation of HOXC6, HOXD1, and HOXD8 homeobox gene expression in human neuroblastoma cells following chemical induction of differentiation. |journal=Tumour Biol. |volume=17 |issue= 1 |pages= 34–47 |year= 1996 |pmid= 7501971 |doi=10.1159/000217965 }}
- {{cite journal |vauthors=Guazzi S, Lonigro R, Pintonello L, etal |title=The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins |journal=EMBO J. |volume=13 |issue= 14 |pages= 3339–47 |year= 1994 |pmid= 7913891 |doi= | pmc=395231 }}
- {{cite journal |vauthors=Rosen DR, Brown RH |title=Dinucleotide repeat polymorphism in the HOX4E locus |journal=Hum. Mol. Genet. |volume=2 |issue= 5 |pages= 617 |year= 1993 |pmid= 8100165 |doi=10.1093/hmg/2.5.617 }}
- {{cite journal |vauthors=Del Campo M, Jones MC, Veraksa AN, etal |title=Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD cluster |journal=Am. J. Hum. Genet. |volume=65 |issue= 1 |pages= 104–10 |year= 1999 |pmid= 10364522 |doi=10.1086/302467 | pmc=1378080 }}
- {{cite journal |vauthors=Limongi MZ, Pelliccia F, Gaddini L, Rocchi A |title=Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31→q32.1 |journal=Cytogenet. Cell Genet. |volume=90 |issue= 1–2 |pages= 151–3 |year= 2000 |pmid= 11060466 |doi=10.1159/000015651 }}
- {{cite journal |vauthors=Kosaki K, Kosaki R, Suzuki T, etal |title=Complete mutation analysis panel of the 39 human HOX genes |journal=Teratology |volume=65 |issue= 2 |pages= 50–62 |year= 2002 |pmid= 11857506 |doi= 10.1002/tera.10009 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
{{refend}} External links - {{MeshName|HOXD8+protein,+human}}
{{NLM content}}{{Transcription factors|g3}}{{gene-2-stub}} 1 : Transcription factors |