| 释义 |
- Function
- See also
- References
- Further reading
{{For|the art institute called "INHA"|Institut national d'histoire de l'art}}{{Infobox_gene}}Inhibin, alpha, also known as INHA, is a protein which in humans is encoded by the INHA gene.[1] Function The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone.[2] See alsoReferences1. ^{{cite journal |vauthors=Burger HG, Igarashi M | title = Inhibin: definition and nomenclature, including related substances | journal = Endocrinology | volume = 122 | issue = 4 | pages = 1701–2 |date=April 1988 | pmid = 3345731 | doi = 10.1210/endo-122-4-1701| url = | issn = }}
2. ^{{cite web | title = Entrez Gene: INHA inhibin, alpha| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3623| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal | author=Mellor SL |title=Loss of the expression and localization of inhibin alpha-subunit in high grade prostate cancer |journal=J. Clin. Endocrinol. Metab. |volume=83 |issue= 3 |pages= 969–75 |year= 1998 |pmid= 9506758 |doi=10.1210/jc.83.3.969 |name-list-format=vanc| author2=Richards MG | author3=Pedersen JS | display-authors=3 | last4=Robertson | first4=DM | last5=Risbridger | first5=GP }}
- {{cite journal | author=Munz B |title=A novel role of activin in inflammation and repair |journal=J. Endocrinol. |volume=161 |issue= 2 |pages= 187–93 |year= 1999 |pmid= 10320815 |doi=10.1677/joe.0.1610187 |name-list-format=vanc| author2=Hübner G | author3=Tretter Y | display-authors=3 | last4=Alzheimer | first4=C | last5=Werner | first5=S }}
- {{cite journal |vauthors=Welt C, Sidis Y, Keutmann H, Schneyer A |title=Activins, inhibins, and follistatins: from endocrinology to signaling. A paradigm for the new millennium |journal=Exp. Biol. Med. (Maywood) |volume=227 |issue= 9 |pages= 724–52 |year= 2002 |pmid= 12324653 |doi= }}
- {{cite journal |vauthors=Shav-Tal Y, Zipori D |title=The role of activin a in regulation of hemopoiesis |journal=Stem Cells |volume=20 |issue= 6 |pages= 493–500 |year= 2003 |pmid= 12456957 |doi=10.1634/stemcells.20-6-493 }}
- {{cite journal | author=Shao L |title=Effect of activin A on globin gene expression in purified human erythroid progenitors |journal=Blood |volume=79 |issue= 3 |pages= 773–81 |year= 1992 |pmid= 1310063 |doi= |name-list-format=vanc| author2=Frigon NL | author3=Young AL | display-authors=3 | last4=Yu | first4=AL | last5=Mathews | first5=LS | last6=Vaughan | first6=J | last7=Vale | first7=W | last8=Yu | first8=J }}
- {{cite journal | author=Vannelli GB |title=Immunolocalization of inhibin alpha-subunit in the human testis. A light- and electron-microscopy study |journal=Cell Tissue Res. |volume=269 |issue= 2 |pages= 221–7 |year= 1992 |pmid= 1423490 |doi= 10.1007/bf00319612|name-list-format=vanc| author2=Barni T | author3=Forti G | display-authors=3 | last4=Negro-Vilar | first4=A | last5=Vale | first5=W | last6=Serio | first6=M | last7=Balboni | first7=GC }}
- {{cite journal | author=Matzuk MM |title=Alpha-inhibin is a tumour-suppressor gene with gonadal specificity in mice |journal=Nature |volume=360 |issue= 6402 |pages= 313–9 |year= 1992 |pmid= 1448148 |doi= 10.1038/360313a0 |name-list-format=vanc| author2=Finegold MJ | author3=Su JG | display-authors=3 | last4=Hsueh | first4=Aaron J. W. | last5=Bradley | first5=Allan }}
- {{cite journal |vauthors=Shimonaka M, Inouye S, Shimasaki S, Ling N |title=Follistatin binds to both activin and inhibin through the common subunit |journal=Endocrinology |volume=128 |issue= 6 |pages= 3313–5 |year= 1991 |pmid= 2036994 |doi=10.1210/endo-128-6-3313 }}
- {{cite journal |vauthors=Mason AJ, Berkemeier LM, Schmelzer CH, Schwall RH |title=Activin B: precursor sequences, genomic structure and in vitro activities |journal=Mol. Endocrinol. |volume=3 |issue= 9 |pages= 1352–8 |year= 1990 |pmid= 2575216 |doi=10.1210/mend-3-9-1352 }}
- {{cite journal | author=Barton DE |title=Mapping of genes for inhibin subunits alpha, beta A, and beta B on human and mouse chromosomes and studies of jsd mice |journal=Genomics |volume=5 |issue= 1 |pages= 91–9 |year= 1989 |pmid= 2767687 |doi=10.1016/0888-7543(89)90091-8 |name-list-format=vanc| author2=Yang-Feng TL | author3=Mason AJ | display-authors=3 | last4=Seeburg | first4=P.H. | last5=Francke | first5=U. }}
- {{cite journal | author=Lappöhn RE |title=Inhibin as a marker for granulosa-cell tumors |journal=N. Engl. J. Med. |volume=321 |issue= 12 |pages= 790–3 |year= 1989 |pmid= 2770810 |doi=10.1056/NEJM198909213211204 |name-list-format=vanc| author2=Burger HG | author3=Bouma J | display-authors=3 | last4=Bangah | first4=Mohan | last5=Krans | first5=Mindert | last6=De Bruijn | first6=Henk W.A. }}
- {{cite journal | author=Mayo KE |title=Inhibin A-subunit cDNAs from porcine ovary and human placenta |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 16 |pages= 5849–53 |year= 1986 |pmid= 3016724 |doi=10.1073/pnas.83.16.5849 | pmc=386393 |name-list-format=vanc| author2=Cerelli GM | author3=Spiess J | display-authors=3 | last4=Rivier | first4=J | last5=Rosenfeld | first5=MG | last6=Evans | first6=RM | last7=Vale | first7=W }}
- {{cite journal |vauthors=Ramasharma K, Li CH |title=Characteristics of binding of human seminal alpha-inhibin-92 to human pituitary membranes |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 11 |pages= 3595–8 |year= 1987 |pmid= 3035540 |doi=10.1073/pnas.84.11.3595 | pmc=304921 }}
- {{cite journal | author=Murata M |title=Erythroid differentiation factor is encoded by the same mRNA as that of the inhibin beta A chain |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 8 |pages= 2434–8 |year= 1988 |pmid= 3267209 |doi=10.1073/pnas.85.8.2434 | pmc=280011 |name-list-format=vanc| author2=Eto Y | author3=Shibai H | display-authors=3 | last4=Sakai | first4=M | last5=Muramatsu | first5=M }}
- {{cite journal |vauthors=Burger HG, Igarashi M |title=Inhibin: definition and nomenclature, including related substances |journal=Endocrinology |volume=122 |issue= 4 |pages= 1701–2 |year= 1988 |pmid= 3345731 |doi=10.1210/endo-122-4-1701 }}
- {{cite journal |vauthors=Mason AJ, Niall HD, Seeburg PH |title=Structure of two human ovarian inhibins |journal=Biochem. Biophys. Res. Commun. |volume=135 |issue= 3 |pages= 957–64 |year= 1986 |pmid= 3754442 |doi=10.1016/0006-291X(86)91021-1 }}
- {{cite journal | author=Stewart AG |title=Human inhibin genes. Genomic characterisation and sequencing |journal=FEBS Lett. |volume=206 |issue= 2 |pages= 329–34 |year= 1986 |pmid= 3758355 |doi=10.1016/0014-5793(86)81006-7 |name-list-format=vanc| author2=Milborrow HM | author3=Ring JM | display-authors=3 | last4=Crowther | first4=C | last5=Forage | first5=R }}
- {{cite journal |vauthors=Xu J, McKeehan K, Matsuzaki K, McKeehan WL |title=Inhibin antagonizes inhibition of liver cell growth by activin by a dominant-negative mechanism |journal=J. Biol. Chem. |volume=270 |issue= 11 |pages= 6308–13 |year= 1995 |pmid= 7890768 |doi=10.1074/jbc.270.11.6308 }}
- {{cite journal |vauthors=Nishihara T, Okahashi N, Ueda N |title=Activin A induces apoptotic cell death |journal=Biochem. Biophys. Res. Commun. |volume=197 |issue= 2 |pages= 985–91 |year= 1994 |pmid= 8267637 |doi= 10.1006/bbrc.1993.2576 }}
- {{cite journal |vauthors=Mason AJ, Farnworth PG, Sullivan J |title=Characterization and determination of the biological activities of noncleavable high molecular weight forms of inhibin A and activin A |journal=Mol. Endocrinol. |volume=10 |issue= 9 |pages= 1055–65 |year= 1997 |pmid= 8885240 |doi=10.1210/me.10.9.1055 }}
{{refend}}{{TGFβ receptor superfamily modulators}}{{gene-2-stub}} |