José Flores may refer to:

• José Asunción Flores (1904–1972), Paraguayan composer
• José Oscar Flores (born 1971), Argentine footballer
• Jose Flores (baseball coach) (born 1971), Puerto Rican baseball coach
• Jose Flores (infielder) (born 1973), American baseball player
• Jose Flores (jockey) (1960–2018), Peruvian-American jockey

• South African Republic (1914-1915)
• South African republic referendum, 1960
• South African rugby union captains
• South African sanctions
• South African Security Police (disambiguation)
• South African Sharp-Nosed Frog
• South African sharp-nosed frog
• South African shield-snouted amphisbaenian
• South African Shooting Sport Confederation
• South Africans in Norway
• South African soccer team
• South African socket
• South African sockets
• South African steam locomotive tenders
• South African student protests of 2015
• South African Super League
• South African Table Tennis Board
• South African Taekwondo Federation
• South African Tennis Association
• South African Time
• South African Tourism
• South African trade embargo
• South African Trades Union Council
• South African Transitional Executive Council
• South African Transport and Allied Workers' Union