| 释义 |
- See also
- References
- Further reading
- External links
{{Infobox_gene}}Krueppel-like factor 12 is a protein that in humans is encoded by the KLF12 gene.[1][2]{{PBB_Summary
| section_title =
| summary_text = Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene.[3]
}}See alsoReferences1. ^{{cite journal |vauthors=Roth C, Schuierer M, Gunther K, Buettner R | title = Genomic structure and DNA binding properties of the human zinc finger transcriptional repressor AP-2rep (KLF12) | journal = Genomics | volume = 63 | issue = 3 | pages = 384–90 |date=Jul 2000 | pmid = 10704285 | pmc = | doi = 10.1006/geno.1999.6084 }}
2. ^{{cite web | title = Entrez Gene: KLF12 Kruppel-like factor 12| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11278| accessdate = }}
3. ^{{cite web | title = Entrez Gene: KLF12 Kruppel-like factor 12| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11278| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Imhof A, Schuierer M, Werner O, etal |title=Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/egr-related zinc finger repressor |journal=Mol. Cell. Biol. |volume=19 |issue= 1 |pages= 194–204 |year= 1999 |pmid= 9858544 |doi= | pmc=83878 }}
- {{cite journal |vauthors=Zhang QH, Ye M, Wu XY, etal |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=10.1101/gr.140200 | pmc=310934 }}
- {{cite journal |vauthors=Schuierer M, Hilger-Eversheim K, Dobner T, etal |title=Induction of AP-2alpha expression by adenoviral infection involves inactivation of the AP-2rep transcriptional corepressor CtBP1 |journal=J. Biol. Chem. |volume=276 |issue= 30 |pages= 27944–9 |year= 2001 |pmid= 11373277 |doi= 10.1074/jbc.M100070200 }}
- {{cite journal |vauthors=Zhu CH, Huang Y, Broman MT, Domann FE |title=Expression of AP-2 alpha in SV40 immortalized human lung fibroblasts is associated with a distinct pattern of cytosine methylation in the AP-2 alpha promoter |journal=Biochim. Biophys. Acta |volume=1519 |issue= 1–2 |pages= 85–91 |year= 2001 |pmid= 11406275 |doi= 10.1016/s0167-4781(01)00227-5}}
- {{cite journal |vauthors=Chen C, Brabham WW, Stultz BG, etal |title=Defining a common region of deletion at 13q21 in human cancers |journal=Genes Chromosomes Cancer |volume=31 |issue= 4 |pages= 333–44 |year= 2001 |pmid= 11433524 |doi= 10.1002/gcc.1152 }}
- {{cite journal |vauthors=Rozenblum E, Vahteristo P, Sandberg T, etal |title=A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer development: identification and characterization of candidate genes |journal=Hum. Genet. |volume=110 |issue= 2 |pages= 111–21 |year= 2002 |pmid= 11935316 |doi= 10.1007/s00439-001-0646-6 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
- {{cite journal |vauthors=Dunham A, Matthews LH, Burton J, etal |title=The DNA sequence and analysis of human chromosome 13 |journal=Nature |volume=428 |issue= 6982 |pages= 522–8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379 | pmc=2665288 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
- {{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
- {{cite journal |vauthors=Suda S, Rai T, Sohara E, etal |title=Postnatal expression of KLF12 in the inner medullary collecting ducts of kidney and its trans-activation of UT-A1 urea transporter promoter |journal=Biochem. Biophys. Res. Commun. |volume=344 |issue= 1 |pages= 246–52 |year= 2006 |pmid= 16615998 |doi= 10.1016/j.bbrc.2006.03.138 }}
{{refend}} External links - {{MeshName|KLF12+protein,+human}}
{{NLM content}}{{Transcription factors|g2}}{{gene-13-stub}} 1 : Transcription factors |