“MAP4K2”的意思、由来-开放百科全书

Function

The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1.^[2] A recent study showed that MAP4K2 is a direct kinase of LATS1/2 and thus regulates the Hippo pathway effectors YAP and TAZ.^[3]^[4]

References

1. ^{{cite journal | vauthors = Katz P, Whalen G, Kehrl JH | title = Differential expression of a novel protein kinase in human B lymphocytes. Preferential localization in the germinal center | journal = The Journal of Biological Chemistry | volume = 269 | issue = 24 | pages = 16802–9 | date = Jun 1994 | pmid = 7515885 | pmc = | doi = }}
2. ^¹{{cite web | title = Entrez Gene: MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5871| accessdate = }}
3. ^{{Cite journal| last = Meng| first = Zhipeng| last2 = Moroishi| first2 = Toshiro| last3 = Guan| first3 = Kun-Liang| date = 2016-01-01| title = Mechanisms of Hippo pathway regulation| journal = Genes & Development| language = en| volume = 30| issue = 1| pages = 1–17| doi = 10.1101/gad.274027.115| issn = 0890-9369| pmc = 4701972| pmid = 26728553}}
4. ^{{Cite journal| last = Meng| first = Zhipeng| last2 = Moroishi| first2 = Toshiro| last3 = Mottier-Pavie| first3 = Violaine| last4 = Plouffe| first4 = Steven W.| last5 = Hansen| first5 = Carsten G.| last6 = Hong| first6 = Audrey W.| last7 = Park| first7 = Hyun Woo| last8 = Mo| first8 = Jung-Soon| last9 = Lu| first9 = Wenqi| date = 2015-10-05| title = MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway| journal = Nature Communications| language = en| volume = 6| pages = 8357| doi = 10.1038/ncomms9357| pmc = 4600732| pmid = 26437443}}
5. ^{{cite journal | vauthors = Ren M, Zeng J, De Lemos-Chiarandini C, Rosenfeld M, Adesnik M, Sabatini DD | title = In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 10 | pages = 5151–5 | date = May 1996 | pmid = 8643544 | pmc = 39423 | doi = 10.1073/pnas.93.10.5151 }}
6. ^{{cite journal | vauthors = Yuasa T, Ohno S, Kehrl JH, Kyriakis JM | title = Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38 | journal = The Journal of Biological Chemistry | volume = 273 | issue = 35 | pages = 22681–92 | date = Aug 1998 | pmid = 9712898 | doi = 10.1074/jbc.273.35.22681 }}

Further reading

{{cite journal | vauthors = Vionnet N, Stoffel M, Takeda J, Yasuda K, Bell GI, Zouali H, Lesage S, Velho G, Iris F, Passa P | title = Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus | journal = Nature | volume = 356 | issue = 6371 | pages = 721–2 | date = Apr 1992 | pmid = 1570017 | doi = 10.1038/356721a0 }}

{{cite journal | vauthors = Matsutani A, Janssen R, Donis-Keller H, Permutt MA | title = A polymorphic (CA)n repeat element maps the human glucokinase gene (GCK) to chromosome 7p | journal = Genomics | volume = 12 | issue = 2 | pages = 319–25 | date = Feb 1992 | pmid = 1740341 | doi = 10.1016/0888-7543(92)90380-B }}

{{cite journal | vauthors = Pombo CM, Kehrl JH, Sánchez I, Katz P, Avruch J, Zon LI, Woodgett JR, Force T, Kyriakis JM | title = Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase | journal = Nature | volume = 377 | issue = 6551 | pages = 750–4 | date = Oct 1995 | pmid = 7477268 | doi = 10.1038/377750a0 }}

{{cite journal | vauthors = Ren M, Zeng J, De Lemos-Chiarandini C, Rosenfeld M, Adesnik M, Sabatini DD | title = In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 10 | pages = 5151–5 | date = May 1996 | pmid = 8643544 | pmc = 39423 | doi = 10.1073/pnas.93.10.5151 }}

{{cite journal | vauthors = Guru SC, Agarwal SK, Manickam P, Olufemi SE, Crabtree JS, Weisemann JM, Kester MB, Kim YS, Wang Y, Emmert-Buck MR, Liotta LA, Spiegel AM, Boguski MS, Roe BA, Collins FS, Marx SJ, Burns L, Chandrasekharappa SC | title = A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus | journal = Genome Research | volume = 7 | issue = 7 | pages = 725–35 | date = Jul 1997 | pmid = 9253601 | pmc = 310681 | doi = 10.1101/gr.7.7.725 }}

{{cite journal | vauthors = Yuasa T, Ohno S, Kehrl JH, Kyriakis JM | title = Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38 | journal = The Journal of Biological Chemistry | volume = 273 | issue = 35 | pages = 22681–92 | date = Aug 1998 | pmid = 9712898 | doi = 10.1074/jbc.273.35.22681 }}

{{cite journal | vauthors = Chadee DN, Yuasa T, Kyriakis JM | title = Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2 | journal = Molecular and Cellular Biology | volume = 22 | issue = 3 | pages = 737–49 | date = Feb 2002 | pmid = 11784851 | pmc = 133545 | doi = 10.1128/MCB.22.3.737-749.2002 }}

{{cite journal | vauthors = Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Kéri G, Wehland J, Daub H | title = Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry | journal = Molecular & Cellular Proteomics | volume = 6 | issue = 3 | pages = 537–47 | date = Mar 2007 | pmid = 17192257 | doi = 10.1074/mcp.T600062-MCP200 }}

Function

Interactions

References

Further reading